Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immuno > Immuno Cytokines > Flashcards

Immuno Cytokines Flashcards

1
Q

TNF Source

A

Macrophage, T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

TNF Target

A

Endothelia, epithelia, neutrophils, hypothalamus, liver, muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

TNF Fc

A

Activation (inflammation) Activation / oxidative burst Fever,acute phase protein synthesis, cachexia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

IL-1 Source

A

Macrophages, endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

IL-1 Target

A

Endothelia Hypothalamus liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

IL-1 Fc

A

Activation (inflammation)
Fever
Acute phase protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

IL-6 Source

A

Macrophages, endothelial cells T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

IL-6 Target

A

Liver
B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IL-6 Fc

A

Acute phase protein synthesis Proliferation of antibody producing B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

IL-12 Source

A

Dendritic cells, macrophage, what about NK???

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

IL-12 Target

A

NK cells, T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

IL-12 Fc

A

Increase IFN_ secretion, increase cytotoxic activity, Th1 differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

IL-23 Source

A

Dendritic cells, macrophage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

IL-23 Target

A

T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IL-23 Fc

A

Promote Th17 differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IL-8 + others Source

A

Macrophages, dendritic cells, endothelia, T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

IL-8 + others Target

A

leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

IL-8 + others Fc

A

PMN chemotaxis, leukocyte migration, dendritic cell lymph node migration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

IFN_/IFN_ Source

A

Dendritic cells (IFN_) Fibroblasts (IFN_)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

IFN_/IFN_ Target

A

All cells

21
Q

IFN_/IFN_ Fc

A

Antiviral immunity, increase class I MHC expression
Activate NK cells

22
Q

IFN_ Source

A

Th1 T cells

23
Q

IFN_ Target

A

Macrophage, B cell

24
Q

IFN_ Fc

A

Activate macrophage, isotype switching in B cells to IgG

25
Q

IL4, IL5, IL13 Source

A

Th2 T cells

26
Q

IL4, IL5, IL13 Target

A

B cells

27
Q

IL4, IL5, IL13 Fc

A

Isotype switching in B cells to IgE

28
Q

IL17 Source

A

TH17 T cells

29
Q

IL17 Target

A

PMNs, epithelia

30
Q

IL17 Fc

A

Activate / Mitogen for PMNs, increase antimicrobial peptides

31
Q

TGF_ Source

A

epithelia, NK cells, Tregs, fibroblasts, endothelia, others

32
Q

TGF_ Target

A

T cells, B cell

33
Q

TGF_ Fc

A

Suppress Th1 and Th2 development, promote Th17 differentiation, increase B cell IgA isotype switching

34
Q

IL10 Source

A

Macrophages, dendritic cells, Th2 cells

35
Q

IL10 Target

A

Macrophages, dendritic cells, T cells

36
Q

IL10 Fc

A

Inhibit IL12 production, reduce MHC class II and costimulatory molecule expression

37
Q

IL2 Source

A

Activated T cells

38
Q

IL2 Target

A

Autocrine activated T cells

39
Q

IL2 Fc

A

Mitogen for activated (mature) nai_ve T cells

40
Q

IL7 Source

A

bone marrow stromal cells

41
Q

IL7 Target

A

Immature T and B lymphocytes

42
Q

IL7 Fc

A

Mitogen for developing immature lymphocytes

43
Q

IL15, IL18 Source

A

macrophages

44
Q

IL15, IL18 Target

A

NK cells

45
Q

IL15, IL18 Fc

A

Mitogen for NK cells, IFN_ production

46
Q

G-CSF, GM-CSF

A

Macrophages, T cells

47
Q

G-CSF, GM-CSF

A

Immature myeloid cells

48
Q

G-CSF, GM-CSF

A

Mitogen for myeloid progenitor cells, immune suppression

Immuno (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions