Immuno - Antibodies

Question 1

APS

Answer 1

anti-cardiolipin, lupus anticoagulant

Question 2

AI hepatitis

Answer 2

Anti-smooth muscle antibody Liver-kidney-microsomal antibody

Question 3

Churg-Strauss/eGPA

Answer 3

p-ANCA

AB to myeloperoxidase

Question 4

Coeliac

Answer 4

anti-TTG, anti-endomysial (most specific) (anti-gliadin, not specific)

Question 5

Dermatitis herpetiformis

Answer 5

anti-endomysial (think coeliac associated)

Question 6

Dermatomyositis

Answer 6

Anti-Jo1

Question 7

Diffuse scleroderma

Answer 7

Anti-scl70 (topoisomerase)

Question 8

Limited scleroderma (CREST)

Answer 8

Anti-centromere

Question 9

Goodpasture’s

Answer 9

anti-GBM

Question 10

Graves

Answer 10

anti-TSHr (stimulatory)

Question 11

Hashimoto’s

Answer 11

anti-thyroglobulin and anti-thyroperoxidase

Question 12

Microscopic polyangitis (MPA)

Answer 12

p-ANCA

AB to myeloperoxidase

Question 13

Myasthenia Gravis

Answer 13

Anti-ACh receptor (non stimulatory)

Question 14

Pernicious anaemia

Answer 14

anti-parietal cell and anti-intrinsic factor

Question 15

Polymyositis

Answer 15

Anti-Jo1

Question 16

PBC

Answer 16

AMA

Question 17

RA

Answer 17

Anti CCP (most specific), Rf

Question 18

SLE

Answer 18

Anti-dsDNA (most specific) Anti-Ro, La, Sm (anti-ENAs)

Question 19

Sjögrens

Answer 19

Anti-Ro, Anti-La

Question 20

T1DM antibodies

Answer 20

Anti-glutamic acid decarboxylase (GAD)

Anti Islet Antigen 2 (IA2)

The above two are also the targets for CD8+. Other antibodies include:

Anti-islet cell Abs

Anti-insulin Abs

Question 21

HLA for coeliac

Answer 21

DQ2 and DQ8

Question 22

SLE HLA

Answer 22

DR-3

Question 23

RA HLA

Answer 23

DR-1 DR-4

Question 24

Staining pattern for dsDNA Ab

Answer 24

Homogenous (smooth) staining of nucleus

Question 25

GPA/Wegner’s

Answer 25

cANCA

Antibodies to proteinase 3