Immuno - Antibodies Flashcards

1
Q

APS

A

anti-cardiolipin, lupus anticoagulant

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2
Q

AI hepatitis

A

Anti-smooth muscle antibody Liver-kidney-microsomal antibody

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3
Q

Churg-Strauss/eGPA

A

p-ANCA

AB to myeloperoxidase

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4
Q

Coeliac

A

anti-TTG, anti-endomysial (most specific) (anti-gliadin, not specific)

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5
Q

Dermatitis herpetiformis

A

anti-endomysial (think coeliac associated)

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6
Q

Dermatomyositis

A

Anti-Jo1

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7
Q

Diffuse scleroderma

A

Anti-scl70 (topoisomerase)

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8
Q

Limited scleroderma (CREST)

A

Anti-centromere

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9
Q

Goodpasture’s

A

anti-GBM

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10
Q

Graves

A

anti-TSHr (stimulatory)

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11
Q

Hashimoto’s

A

anti-thyroglobulin and anti-thyroperoxidase

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12
Q

Microscopic polyangitis (MPA)

A

p-ANCA

AB to myeloperoxidase

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13
Q

Myasthenia Gravis

A

Anti-ACh receptor (non stimulatory)

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14
Q

Pernicious anaemia

A

anti-parietal cell and anti-intrinsic factor

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15
Q

Polymyositis

A

Anti-Jo1

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16
Q

PBC

A

AMA

17
Q

RA

A

Anti CCP (most specific), Rf

18
Q

SLE

A

Anti-dsDNA (most specific) Anti-Ro, La, Sm (anti-ENAs)

19
Q

Sjögrens

A

Anti-Ro, Anti-La

20
Q

T1DM antibodies

A

Anti-glutamic acid decarboxylase (GAD)

Anti Islet Antigen 2 (IA2)

The above two are also the targets for CD8+. Other antibodies include:

Anti-islet cell Abs

Anti-insulin Abs

21
Q

HLA for coeliac

A

DQ2 and DQ8

22
Q

SLE HLA

A

DR-3

23
Q

RA HLA

A

DR-1 DR-4

24
Q

Staining pattern for dsDNA Ab

A

Homogenous (smooth) staining of nucleus

25
Q

GPA/Wegner’s

A

cANCA

Antibodies to proteinase 3