Immuno Flashcards
What does Th1 make
- what is differentiation induced by
- what is inhibited by
IFNg (activates macrophages)
IL2 (cytotoxic T cells)
Differentation by IFNgamma and IL12
Inhibited by IL4 and IL10
What does TH2 make
- what is differentiation induced by
- what is inhibited by
IL4, 5, 6, 10 ,13
Diff by IL2 and 4
Inhibited by IFNgamma
What does IL6
stimulates production of acute phase proteins
what cytokines are released by macrophages?
IL1, 6, 8, 12, TNFa
what does IL8 do
major chemotactic factor for neutrophils
what does IL 12 do
induces differentiation of T cells into TH1 cells
Activates NK cells
what does TNf alpha do?
- 3 good
- bad
activates endoderm-needed, causes WBC recruitment, and vascular leak
cachexia in malignancy
What do all T cell secrete?
IL2 and 3
What does IL 2 do
Stimulates growth of all T cells and NK cells
What does IL3 do
Supports growth and differentiation of bone marrow stem cells-like GMCSF
What does IFNgamma do?
Secreted by NK cells and T cells in response to antigen or IL12
stim macrophages to kill phagocystosed pathogens
Inhibits Th2 differenation
what does IL4 do
3
induces differentiation of T cells to TH2
Promtes growth of B cells
Class switching to IgE and IgG
what does IL5 do
3
promotes growth and differentiation of B cells
Enchanges class switching to IgA
Stimulates growth and differentiation of eos
What does IL10 do?
3
attenuates inflammatoryresponse=antiinflamtory!
- decrases expression of MHC class 2 and TH1 cytokines
- inhibits activated macrophages
IL11
megakaryocytic production-use at thrombocytopenia-oprevkin
What does CD14 do?
allow macrophages to see LPS in gm- orgs
what do lipoteichoic acids do
only on gm+
induce TNFa and IL1
What three orgs have IgA protease?
s phenol, h flu type b, neisseria
What is protein A?
binds Fc of IgG and prevent opsonization-S aureus
What is exotoxin A
pseudomonas-inactivates E2F
strep penumo-binds to MHC2 and TCR and causes overwhelming release of cytokines-toxic shock like syndrome/scarlet fever (tech for Staph aureus TSST too/staph scalded skin)
