Immuno

Question 1

Expansion of what cells via what mechanism helps preserve oral tolerance? What do those cells release that helps suppress immune responses?

Answer 1

Expansion of iTregs via TGF-B, RA, and IDO preserve oral tolerance by releasing IL-10 which helps suppress immune responses to allergens

Question 2

Which 3 vitamins help suppress inflammatory responses?

What do gut microbiota induce to suppress immune responses?

Answer 2

Vit. D, A, and folate help suppress responses

Microbiota induce Tregs which can suppress basophils, mast cells, and TH2 induced IgE production

Question 3

Cross linking of what plays a major role in food induced anaphylaxis?

Answer 3

Mast cells are activated by IgE crosslinking with FCeRI resulting in release of histamine and PAF which increase vascular permeability and cause smooth muscle contraction

Question 4

What two factors are associated with a genetic disposition to celiac disease?

Answer 4

HLA-DQ2 and HLA-DQ8

Question 5

What role do HLA-DQ2/8 play in celiac disease? What is the mechanism of the disease?

Answer 5

HLA-DQ2/8 present gluten Ag and activate CD4 cells to secrete IFN-gamma which activate MMP which remodel gut mucosa and cause villi atrophy