immuno

Question 1

HLA-A2

Answer 1

hemochomatosis

Question 2

HLA-B27

Answer 2

psoriatic arthritis
ankylosing spondyloarthritis
IBD-associated arthritis
reactive arthritis

Question 3

HLA-DQ2/DQ8

Answer 3

celiac disease

Question 4

HLA-DR2

Answer 4

multiple sclerosis
hay fever
SLE
goodpasture syndrome

Question 5

HLA-DR3

Answer 5

DM 1
SLE
graves
hashimoto

Question 6

HLA-DR4

Answer 6

rheumatoid arthritis

DM 1

Question 7

HLA-DR5

Answer 7

pernicious anemia

hashimoto

Question 8

IgG

Answer 8

secondary (delayed) response to Ag
most abundant isotype in serum
fixes complement
crosses placenta - passive immunity to infant
opsonizes bacteria
neutralizes bacterial toxins & viruses

Question 9

IgA

Answer 9

in mucosa
prevents attachment of bacteria & viruses to mucous membranes
monomer in circulation, dimer when secreted
crosses EP cells via transcytosis
prod in Peyers patches –> protect GI from infxn
most produced Ab overall, but lower serum concentrations
released in secretions (tears, saliva, mucus) & breast milk

Question 10

IgM

Answer 10

primary (immediate) response to Ag
fixes complement
Ag Rc on B cells
monomer on B cell, pentamer when secreted = avid binding to Ag

Question 11

IgD

Answer 11

unclear fxn

on surface of B cells & in serum

Question 12

IgE

Answer 12

binds mast cells & basophils
crosslinks when exposed to allergen –> release of inflammatory mediators –> type I hypersensitivity rxn
activates eosinophils in parasitic infxns
lowest concentration in serum

Question 13

C-reactive protein

Answer 13

acute phase reactant
opsonin
fixes complement & facilitates complement

Question 14

ferritin

Answer 14

binds & sequesters iron to (-) microbial iron sequestration

Question 15

fibrinogen

Answer 15

coagulation factor
promotes endothelial repair
correlates w/ ESR

Question 16

hepcidin

Answer 16

prevents release of iron bound by ferritin –> anemia of chronic disease

Question 17

IL-1

Answer 17

fever, acute inflammation
activates endothelium to express adhesion molec
induces chemokine secretion to recruit WBC

[macrophages]

Question 18

IL-2

Answer 18

(+) growth of T cells & NK cells

[Th1 &Th2 cells]

Question 19

IL-3

Answer 19

supports growth & differentiation of BM stem cells
fxn like GM-CSF

[TH1 & TH2 cells]

Question 20

IL-4

Answer 20

induces differentiation into Th2 cells 
promotes growth of B cells 
class switching to IgE & IgG

[Th2 cells]

Question 21

IL-5

Answer 21

promotes differentiation of B cells
class switching to IgA
growth & differentiation of eosinophils

[Th2 cells]

Question 22

IL-6

Answer 22

fever
stimulates production of acute phase reactants

[macrophages]

Question 23

IL-8

Answer 23

major chemotactic factor for neutrophils

[macrophages]

Question 24

IL-10

Answer 24

inhibits Th1
inhibits macrophages

[Th2 cells]

Question 25

Il-12

Answer 25

differentiation into Th1 activates NK cells [macrophages]

Question 26

TNFa

Answer 26

``` activates endothelium WBC recruitment vascular leak mediates septic shock cachexia in malignancy ``` [macrophages]

Question 27

IFNy

Answer 27

stimulates macrophages to kill phagocytosed pathogens [Th1 cells]

Question 28

IFNa & IFNb

Answer 28

synthesized by virus infected cells --> act locally on uninfected cells to "prime them" for viral defense - (-) cellular protein synthesis - (+) activation of ribonuclease that degrades viral mRNA apoptosis --> disrupts viral amplification

Question 29

Th1 cytokines

Answer 29

IL-2 IL-3 IFNy

Question 30

Th2 cytokines

Answer 30

``` IL-2 IL-3 IL-4 IL-5 IL-10 ```

Question 31

macrophage cytokines

Answer 31

``` IL-1 IL-6 IL-8 IL-12 TNFa ```

Question 32

helper T cell surface markers

Answer 32

``` CD4 CD40L TCR CD3 CD28 ```

Question 33

cytotoxic T cell surface markers

Answer 33

CD8 TCR CD3 CD28

Question 34

regulatory T cell surface markers

Answer 34

``` CD4 CD25 TCR CD3 CD28 ```

Question 35

B cell surface markers

Answer 35

``` Ig CD19, CD20, CD21 CD40 MHC I MHC II, B7 ```

Question 36

macrophage surface markers

Answer 36

CD14 CD40 MHC II, B7 Fc & C3b Rc

Question 37

NK cell surface markers

Answer 37

CD16 | CD56

Question 38

hematopoietic stem cell surface markers

Answer 38

CD34

Question 39

anti-ACh Rc

Answer 39

myasthenia gravis

Question 40

anti-basement membrane

Answer 40

goodpasture syndrome

Question 41

anticardiolipin | lupus anticoagulant

Answer 41

SLE | antiphospholipid syndrome

Question 42

anti-centromere

Answer 42

limited scleroderma - CREST syndrome

Question 43

anti-desmosome (anti-desmoglein)

Answer 43

pemphigus vulgaris

Question 44

anti-dsDNA | anti-smith

Answer 44

SLE

Question 45

anti-glutamic acid decarboxylase

Answer 45

DM 1

Question 46

anti-hemidesmosome

Answer 46

bullous phemphigoid

Question 47

anti-histone

Answer 47

drug induced lupus

Question 48

anti-Jo1 anti-Mi2 anti-SRP

Answer 48

polymyositis | dermatomyositis

Question 49

anti-microsomal | anti-thyroglobulin

Answer 49

hasimoto thyroiditis

Question 50

ANA

Answer 50

SLE | non-specific

Question 51

anti-parietal cell

Answer 51

pernicious anemia

Question 52

anti-mitochondrial

Answer 52

primary biliary cirrhosis

Question 53

anti-Scl-70 | anti-DNA topo I

Answer 53

diffuse scleroderma

Question 54

anti-smooth muscle

Answer 54

autoimmune hepatitis

Question 55

anti-SSA (anti-Ro) | anti-SSB (anti-La)

Answer 55

sjogren syndrome

Question 56

anti-U1 RNP

Answer 56

mixed CT disease

Question 57

IgA anti-endomysial | IgA anti-tissue transglutaminase

Answer 57

celiac

Question 58

MPO-ANCA / p-ANCA

Answer 58

microscopic polyangitis | eosinophilic granulomatosis w/ polyangiitis (Churg-Strauss)

Question 59

PR3-ANCA / c-ANCA

Answer 59

granulomatosis w/ polyangiitis

Question 60

rheumatoid factor | anti-citrulinated peptide

Answer 60

rheumatoid arthritis