Immunization (Mehlmann FM 236))

Question 1

What is Immunization

Answer 1

The process of inducing immunity against a specific disease

Question 2

What are the types of immunization?

Answer 2

1) Passive immunization
2) Active immunization

Question 3

What is Passive immunization?

Answer 3

The administration of preformed antibodies to induce transient protection against an infectious agent

Question 4

What is Natural passive immunity?

Answer 4

Transplacental transfer of maternal antibodies during pregnancy provides protection for infants in the first few months

Question 5

Indications for passive immunization?

Answer 5

1) Immune deficiency
2) Prophylactically: Post exposure prophylaxis
3) Therapeutically: To suppress the effect of a toxin or the inflammatory response

Question 6

Types of passive immunization?

Answer 6

1) Intramuscular IG
2) Intravenous immunoglobulin
3) Hyperimmune globulins
4) Monoclonal antibodies

Question 7

What is intramuscular Immunoglobulin?

Answer 7

A concentrated antibody-containing solution prepared from large pools of human plasma

Question 8

Intramuscular Immunoglobulin mostly contains which Ig?

Answer 8

IgG

Question 9

Indications for Intramuscular Immunoglobulin?

Answer 9

1) Prophylaxis for:
a) Hepatitis A
b) Measles

2) Immunoglobulin deficiency

Question 10

Side effects of Intramuscular Immunoglobulin?

Answer 10

1) Anaphylaxis
2) Local inflammatory reaction

Question 11

Intravenous immunoglobulin is prepared from:

Answer 11

Adult plasma donors

Question 12

Intravenous Immunoglobulin mostly contains which Ig?

Answer 12

IgG

Question 13

Indications for using Intravenous Immunoglobulin?

Answer 13

1) Prevention of serious bacterial infections in HIV and chronic B-cell leukemia
2) Immune deficiency disorders
3) Treatment of Kawasaki disease
4) Immune mediated thrombocytopenia
5) Prevention of infection after Bone Marrow Transplant
6) TSS, GBS, and anemia caused by B19

Question 14

Side effects of Intravenous Immunoglobulin?

Answer 14

1) Infusion rate related: fever, headache, myalgia, chills, nausea, and vomiting
2) Anaphylactoid reaction
3) Thromboembolic disorders
4) Aseptic meningitis
5) Renal insufficiency

Question 15

When should we vaccinate for Hep. A?

Answer 15

1) If going to endemic areas (e.g., Mexico, India).
2) Homosexuals
3) IV drug users!!!

Question 16

What is the vaccine schedule for Hep. B?

Answer 16

Birth, 2 months, 6 months.

Question 17

Do we give the neonate Hep. B IVIG if the mother’s status is unknown?

Answer 17

No, only vaccine.

Question 18

Do we give the neonate Hep. B IVIG if the mother’s status is Hep. B positive?

Answer 18

Yes

Question 19

What type of vaccine is the Rotavirus vaccine?

Answer 19

Oral live-attenuated

Question 20

What is the vaccine schedule for Rotavirus?

Answer 20

2, 4, 6 months

Question 21

DTaP vaccine includes:

Answer 21

1) Diphtheria
2) Tetanus
3) Acellular Pertussis