Immunity To Infectious Diseases: Viruses & Fungi

Question 0

Mechanism of tissue damage, cytopathic viruses

Answer 0

Interferes with cellular protein synthesis leading to injury/death

Question 1

Viruses: 2 modes of transmission

Answer 1

Mucosal surfaces

Epithelial surfaces

Question 2

Mechanism of tissue damage,noncytopathic viruses

Answer 2

Viral DNA persists in host cell,causing latent infections. When expressed, protein synthesis altered, leading to disease

Question 3

Interferon ____ is produced by fibroblasts

Answer 3

Beta

Question 4

Which cytokines activate NK cell?

Answer 4

IL-12, IL-15

Question 5

What prompts the NK cells to lyse a cell?

Answer 5

Absence of a properly functioning MHC I Marker

Question 6

Interferon ___ is produced by leukocytes

Answer 6

Alpha

Question 7

Interferon alpha increases expression of IL-__ which leads to production of IFN gamma @ T cells and NK cells

Answer 7

12

Question 8

True or false. Antibodies can protect from infection and eradicate established infections

Answer 8

False. It cannot eradicate established infections

Question 9

Exposure to one serological type of virus makes you resistant to all serological types. True or false?

Answer 9

False

Question 10

In CMI, what does cytotoxic T cell induce in viruses?

Answer 10

DNA fragmentation

Question 11

Antigenic variation is done by the following viruses except
A)influenza
B)rhinovirus
C)pox virus

Answer 11

C)pox virus

Question 12

HIV does all immune evasion mechanisms below except?
A.inhibition of antigen processing
B.antigenic variation
C.infection of immunocompetent cells

Answer 12

A.inhibition of antigen processing

Question 13

False about Inhibition of Ag processing
A.blockade of TAP transporter
B.removal of MHC-II molecule from ER

Answer 13

B. Removal of MHC-II molecule fr ER. Dapat MHC-I

Question 14

Production of cytokine receptor molecules done by all of these except?
A)HIV
B)pox virus
C)CMV

Answer 14

A)HIV

Question 15

True or false: Fungi may live within phagocytes

Answer 15

True

Question 16

What are mycoses?

Answer 16

Generalized fungal infection

Question 17

What does endemic mean

Answer 17

Present in environment

Question 18

When do fungi become opportunistic?

Answer 18

Normal flora become pathogenic

Question 19

All Patients on long-term corticosteroids are not susceptible to fungal infection. True or false?

Answer 19

False

Question 20

Most important predisposing factor for clinically significant fungal infection

Answer 20

Compromised immunity

Question 21

Neutrophils attach to ____ of Candida albicans

Answer 21

Pseudohyphae

Question 22

Cationic peptides - fungicidal activity vs ____ phase but not ____

Answer 22

vs hyphal phase but not spores

Question 23

____ inhibits respiratory burst and release of myeloperoxidase by phagocytosing neutrophils

Answer 23

Mannan

Question 24

How does Candida albicans evade body’s immune response?
A)inhibits interaction with neutrophils by producing factor
B)binds to neutrophil receptors
c)both a and b

Answer 24

A)inhibits interaction with neutrophils by producing factor

Question 25

Cryptococcus neoformans inhibits production of these cytokines except
A.TNF
B.IL-12
C.IL-10

Answer 25

C.IL-10

Question 26

Cryptococcus neoformans stimulates the production of this interferon

Answer 26

IL-10

Question 27

TH1 response to intracellular fungi are ____ (protective or detrimental?)

Answer 27

Protective

Question 28

TH2 response to intracellular fungi are ____ (protective or detrimental?)

Answer 28

Detrimental

Question 29

The following are routes of fungal exception except:
A.superficial
B.subcutaneous
C.inhalation
D.local extension
E.subdural

Answer 29

E.subdural

Question 30

Immune system cells that principally mediate response to fungal infection

Answer 30

Neutrophils and macrophages