Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Mandal > immunity and Host Defense Against Oral Infections: Innate & Adaptive Immunity > Flashcards

immunity and Host Defense Against Oral Infections: Innate & Adaptive Immunity Flashcards

1
Q

Host Defenses in Mouth

A
  • depends on integrity of oral mucosa
  • innate immunity
  • adaptive immuntty
    • antigen specific antibody
    • T cell response
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

non-specific denense

saliva

A
  1. saliva flow
  2. Mucin/agglutinins
  3. lysozyme-protease-anion system
  4. Lactoferrin
  5. Salivary lactoperoxidase
  6. histidine-rich polypeptides
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

physico-chemical barriers for saliva

A
  1. intraepithelial barrier
  2. basement membrane barrier
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

immunological barrier of salivia

A
  1. langerhans cells
  2. IEL
  3. Serum IgG
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Host defenses with tooth surfaces

A
  1. Salivia
  2. IgG
  3. IgA
  4. Gingival crevicular fluid
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

neutrophil

A
  • granulocyte
  • phagocyte, innate immunity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

lymphocyte

A
  • agranulocyte
  • adaptive immunity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

monocyte

A
  • agranulocyte
  • phagocyte
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

eosinophil

A
  • granulocyte
  • removal of helminths and Ab-Ag complexes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Basophil

A
  • granulocyte
  • allergy inflammation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

anatomic barriers in oral cells

A
  • innate immunity
  • TLRs
    • recognize PAMPS
    • produce peptide antibodies
    • cytokines
    • NO
    • sIGA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

TLRs

A
  • TLR2
    • binds lipoteichoic acid of gram+ bacteria
  • TLR4
    • binds lipopolysacchrides of gram-bacteria
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Physiologic Barrier

antimicrobial properties of saliva

A
  1. swallowing
  2. pH
  3. Temperature
  4. lactoferrin
  5. lysozyme
  6. myeloperpxidase
  7. Salivary peroxidase
  8. leukocytes
  9. secretory Iga
  10. complement
  11. Histatins
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ph is salivia

A
  • rise in periodontal pocket pH in gingivitis and periodontal disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

temp in salivia

A

makes SOD work better

neutralization of super oxide anions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

lactoferrin in saliva

A

iron-binding

bacteriostatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

lysozyme in salivia

A

breaks down bacterial structure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

myeloperoxidase system in saliva

A
  • bactericidal
  • H2O2 in PMN
  • migrates to gingival crevice (inflammation)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

salivary peroxidase system

A
  • bactericidal
  • generates thiocyanate
  • H2O2
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Histatins in salivia`

A
  • histidine rich broad spectrum
  • antifungal
  • antiviral activity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Defensins in salivia

A
  • broad spectrum antibacterial
  • antifungal
  • antiviral
  • protect mucosal surfaces
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

complement in salivia

A

breaks down C3 derived from GCF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Leukocyted in salivia

A
  • secrete alpha defensin
  • phagocytosis
  • increases in inflammation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

secretory IgA

(sIGA)

A

major Ab in salivia

inhibits agglutinates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

phagocytic barrier

Destruction of Pathogens

A
  • phagocytes bind to microbes using cell-surface receptors via
    • reactive oxygen and nitrogen intermediates
  • Lysosomes
    • proteolytic enzymes
26
Q

Oxygen-independent methods

A
  • Lysozyme
  • Defensins
  • Lactoferrin
  • Proteolytic and hydrolytic enzymes
27
Q

oxygen-dependent methods

A
  • hydrogen peroxidde
  • superoxide anion
  • hydroxyl radical
  • Myeloperoxidase
  • Hypochlorite
  • Hypohalite
  • Nitric Oxide
28
Q

inflammatory barreriers

A

inflammation is body’s physiological response to infection or tissue damage

29
Q

inflammatory main events

6

A
  1. release of inflammatory cytokines (TNF alpha, IL-1)
  2. Cytokines recruit and activate phagocytes
  3. Vasodilation increases blood flow
  4. increased cappilary permeability
  5. leukocytes migrate to reach site of infection( PMNs first then monocytes and lymphocytes)
  6. periodonitis (inflammaiton)
30
Q

anatomy of inflammation

A

pavementing

diapedesis

chemotaxis

31
Q

B- Lymphocytes

A
  • recognize intact protein antigens
  • produce antibody (Ab) via plasma cells
32
Q

T-lymphocytes

general

A
  • recognize peptide Ag via TCR
    • presented by anitgen presenting cells (APC)
33
Q

APCs present Ag to

A

T cells using major histocompatibility complex (MHC)

34
Q

T-lymphocytes

two subtypes

A
  • T-helper
    • Lymphocytes, CD4+
    • recognize extracellular Ag
    • via MHC II
  • Cytotoxic T lymphoctes
    • CTL CD8+
    • recognize intracellular Ag
    • via MHC I
    • kills virus infected cells
35
Q

In HIV infections CD4+ T cells are killed by

A

CD8+ T cells

36
Q

Gingival crevice and 1/3 of tooth crown are protected by GCF that contain which immunoglobulins/Antibody

A
  • IgG
  • IgA
  • IgM
37
Q

Salivary Ab in healthy human mouth is mainly

A

sIgA

38
Q

Abs are usually derived from

A

plasma

39
Q

Ab can be locally synthesized mainly in

A

inflammed gingivae

40
Q

IgG

A
  • monomer
  • crosses the placenta/protects fetus
  • activate complemetn
  • opsonizing

In GCF protects gingival & gingival crown of teeth

41
Q

IgM

A
  • Pentamer
  • First Ab generated against any Ag
  • Main Ab made by fetus
  • ABO blood group Ag

GCF contains IgM, protects gingiva and gingival crowns of the teeth

42
Q

IgA

A
  • dimer secertions ( tears, salivia…)
  • lines oral mucosal surface
    • protect from infection (ruins adhesion molecules on pathogens)
  • uses microogranisms to stop colonization
43
Q

MALT is located in

A

gut

44
Q

where are lyphocyted found in the GI tracat?

A

epithelial layer

lamina propria

Peyer’s patch

45
Q

alteration in normal microflora in oral mucosa leads to

A

inappropriate immune responses

46
Q

GCF

A

Gingival Crevicular Fluid

flushes gingival margin-oral cavity

47
Q

dental plaque at the gingival margain results in

A

acute inflammation by increasing the flow of GCF

48
Q

Dental caries and periodontal diseases are the results of

A

ecological imbalance btwn resident microbes and the host immune response

49
Q

frequent consumption of carbs leads to

A
  • promotes bacteria lactobacilli S.mutans
    • colonize on carb
    • leading to biofilm/dental plaque
50
Q

most inhaled or ingested antigens are taken up by the specialized

A

microfold or M cells

51
Q

oral immunization with protein Ags induce

A

tolerance

52
Q

_________ is important for generation of oral mucosal tolerance

A

CD4+

53
Q

chitinase

A

antifungal in mouth

54
Q

cathelicidin

A

antimicrobial in the mouth

55
Q

complement factors C3a C5a in mouth

A

chemotazis and attraction of phagocytes to the site

56
Q

intra-epithelial lymohocytes and langerhans cells

A

cellular barrier to penetrating bacteria and/ or antigens

57
Q

CD4 t cells

A

secretion of cytokinens

58
Q

sIgA

A

prevents microbial adhesion and metabolism

59
Q

IgG, IgA, IgM

A

prevent microbial adhesion, opsonization and complement activatoin

60
Q

Mucosal immune System

A
  • Microflod (M) cells capture Antigen
  • Dome Area is rich in DCs and contains B cells
  • sIgA provides major defense at mucosal surfaces

Mandal (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions