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IMMUNOSEROLOGY > Immunity > Flashcards

Immunity Flashcards

1
Q

Other term of Natural Immunity?

A

Innate/Non specific

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2
Q

Inborn - provide wide range defense

A

Natural Immunity

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3
Q

Can migrate 30-60 mins to the site of infection

A

Phagocytes/Neutrophils

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4
Q

Type of immunity that continues to develop?

A

Adaptive Immunity

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5
Q

Other term of Adaptive Immunity

A

Acquired/Specific

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6
Q

Consists of the anatomical barriers that prevent infectious agents from infecting the body?

A

First line of defense

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7
Q

Ex of First line of defense

A

Intact Skin, Mucous Membranes, Cilia in Respiratory Tract and Body Secretions

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8
Q

Made from soluble factors or proteins

A

Humoral component

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9
Q

First responders (30-60 mins) and the most efficient phagocyte

A

NEUTROPHILS

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10
Q

If the phagocyte is in the blood?

A

Monocyte

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11
Q

If they migrate to tissue?

A

Macrophages

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12
Q

more efficient in phagocytosis, but compare to neutrophils, it was slower

A

Monocytes/Macrophages

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13
Q

Slow responders - they migrate 16-48 hours in the site of infection

  • Motility is slow
A

Monocytes/Macrophages

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14
Q

Less efficient phagocyte

A

Eosinophils

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15
Q

Major basic protein

A

Eosinophils

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16
Q

Granules contain anti-helminthic properties and nematodes (ex. Ascaris, trichuris, strongyloides)

A

Eosinophil Cationic Protein

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17
Q

If there’s a parasitic infection like trichuris, patient may have?

A

EOSINOPHILIA

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18
Q

Has a role in killing parasites/helminthes

A

Eosinophil

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19
Q

Able to present antigen to Helper t cells

A

Antigen Presenting cells (APC)

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20
Q

It’s main function is to eat pathogens then present it for recognition

A

Dendritic cells

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21
Q

Most efficient APC?

A

Dendritic cells

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22
Q

Main function is phagocityze antigen and present to helper t lymphocytes

A

APC (Antigen Presenting Cells)

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23
Q

Primarily cytotoxic - they destroy cells directly and secrete cytotoxic substances

A

Natural Killer Cells

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24
Q

Kills virus infected cells and tumor cells?

A

Natural killer cells

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25
Q

Highest line of defense?

A

3rd line of defense

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26
Q

Cellular component of specialized lymphocytes?

A

B cells and T cells

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27
Q

Has it’s roots in the study of Immunity - the condition of being resistant to infection

A

IMMUNITY

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28
Q

Performed the first vaccination against smallpox using cowpox?

A

Edward Jenner

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29
Q

Considered the father of immunology for his attenuated vaccines

A

Louis Pasteur

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30
Q

He was the first to observe the phagocytosis - meaning cells that eat cells

A

Metchnikoff

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31
Q

Cells that eat cells?

A

Phagocytosis

32
Q

Humoral component of Third Line of Defense?

A

Antibodies - IgG, IgA, IgM, IgD, IgE
Cytokines

33
Q

What are the stages of Phagocytosis?

A

Adherence
Formation of Phagosome
Engulfment
Formation of Phagolysosome
Granule Contact
Digestion
Excretion

34
Q

Nomenclature of the Liver?

A

Kupffer Cells

35
Q

Nomenclature of the Lungs?

A

Alveolar Macrophage/Dust cells

36
Q

Nomenclature of the Brain/Nervous Tissue?

A

Microglial cells

37
Q

Nomenclature of the connective tissue?

A

Histiocytes

38
Q

Nomenclature of the Spleen?

A

Splenic Macrophage

39
Q

Nomenclature of the Lymph nodes?

A

Littoral cell

40
Q

Nomenclature of the Placenta?

A

Hofbauer cells

41
Q

Bones?

A

Osteoclasts

42
Q

Kidney?

A

Mesangial cells

43
Q

Surface receptors that promote cell to cell interaction?

A

Integrins

44
Q

Substances that coat foreign cells and pathogen to make then more susceptible to phagocytosis?

A

Opsonin

45
Q

Ex of Opsonins

A

CRP, Antibodies, C3b

46
Q

Normal serum constituents that increase by at least 25% due to infections, injury, or trauma to tissues?

A

Acute phase reactants

47
Q

Ex of Acute phase reactants?

A

CRP,
Serum Amyloid A,
Alpha-1 antitrypsin
Fibrinogen
Ceruloplasmin
Haptoglobin
C3

48
Q

We produced antibodies
after infection or we are infected by
certain pathogens, pag nakarecover
na tayo we will produce our own
antibodies around 3- 5 days.

A

INFECTION

49
Q

Induced production of
antibodies (but in acc to studies, the
production of antibodies will decline
after 6 months kaya need ng booster

A

Vaccination

50
Q

Mother will transfer her gG to
her baby during pregnancy
this was important because the
newborn are not able to produce
their own antibodies so they will rely
to the lag that come from the
mother, especially in the 1# few days
of the life of the baby

A

Placental transfer of IgG

51
Q

Also knows as:
Null cells
Large Granular
Lymphocyte
Third Population
Lymphocyte

A

Natural Killer cells

52
Q

Why does B cell involved in humoral
immunity?

A

Because its major product is
antibodies

53
Q

E-rosette receptor?

A

CD2

54
Q

Part of T-cell antigen receptor?

A

CD3

55
Q

Helper T cell/Treg cell?

A

CD4

56
Q

Early stages of T cell?

A

CD5/CD7

57
Q

Part of B cell coreceptor?

A

CD19

58
Q

Found on all stages of B cells

A

CD20

59
Q

Receptor for C3d and EBV

A

CD21

60
Q

Found mostly oncmature B cells

A

CD27

61
Q

receptor for IgG

A

CD16

62
Q

No known function

A

CD56

63
Q

Cortex of thymus?

A

Immature T cells

64
Q

Medulla of Thymus?

A

Mature T cells

65
Q

It is bilobed organ located in the mediastinum or chest cavity?

A

THYMUS

66
Q

site for both B cell development and hematopoiesis?

A

Bone marrow

67
Q

develop in the bone marrow after the hematopoietic stem cells have populated that organ?

A

B cells

68
Q

contains macrophages that destroys old RBCs

A

RED PULP

69
Q

Has lymphocytes and and macrophages

A

White pulp

70
Q

Periaarteriolar Lymphoid Sheath?

A

T cells

71
Q

Primary follicles

A

B cells

72
Q

Marginal zones

A

Dendritic cells

73
Q

Out cortex of Lymph nodes?

A

B cells, dendritic, and macrophage

74
Q

Germinal center of Lymph nodes

A

Plasma cells and memory cells

75
Q

Migration time of Monocytes/Macrophage?

A

16-48 hours

76
Q

Increases by 1000, rises within 6-10 hours

A

Acute phase reactant

IMMUNOSEROLOGY (1 decks)

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