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pre-reg > IMMUNE SYSTEM AND MALIGNANT DISEASE > Flashcards

IMMUNE SYSTEM AND MALIGNANT DISEASE Flashcards

1
Q

what are the side-effects of azathioprine

A
  • hypersensitivity reaction- fever and rash
  • neutropenia + thrombocytopenia
  • nausea
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2
Q

what is the pre-treatment screening for azathioprine/mercaptopurine?

A

TMPT levels
If the patient has low TMPT then they wont be able to convert the drug to activate and this will increase the patient to myelosuppression

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3
Q

Azathioprine + allopurinol

A

INTERACTION!!

Manufacturer advises reduce dose to one-quarter of the usual dose with concurrent use of allopurinol.

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4
Q

MHRA ALERT- relating to tracrolimus

A

Prescribe and dispense by brand name only, to minimise the risk of inadvertent switching between products, which has been associated with reports of toxicity and graft rejection

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5
Q

When monitoring tacrolimus, should peak or trough levels be taken?

A

Trough

Especially when there is diarrhoea, levels need to be closely monitored

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6
Q

What is the MHRA advice surrounding the use of mycophenolic acid/MMF?

A

The MHRA advises to exclude pregnancy in females of child-bearing potential before treatment—2 pregnancy tests 8–10 days apart are recommended. Women should use at least 1 method of effective contraception before and during treatment, and for 6 weeks after discontinuation - 2 are preferred

Mycophenolate medicines remain contraindicated in women of childbearing potential who are not using reliable contraception and in pregnant women unless there are no suitable alternatives to prevent transplant rejection

Male patients or their female partner should use effective contraception during treatment and for 90 days after discontinuation.

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7
Q

Fingolimod, a drug used for MS, carry what MHRA warnings?

A

Signal of rebound effect after stopping or switching therapy

  • Not recommended for patients at known risk of cardiovascular events e.g. persistent bradycardia
  • Has an immunosuppressive effect and can increase the risk of skin cancers and lymphoma - refer patients with any skin lesions
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8
Q

What is the MHRA advice surrounding the use of bevacizumab?

A

Risk of osteonecrosis of the jaw

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9
Q

What is the MHRA advice surrounding the use of EGFR inhibitors e.g. cetuximab?

A

Keratitis and ulcerative keratitis

In rare cases, this has resulted in corneal perforation and blindness

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10
Q

What is the MHRA advice surrounding the use of nivolumab?

A

Risk of organ transplant rejection

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11
Q

Which two cytotoxic drugs do not cause bone marrow suppression?

A

Vincristine

Bleomycin

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12
Q

Ciclosporin can cause what kinds of toxicity?

A

Neurotoxicity

Nephrotoxicity

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13
Q

what is neoadjuvant vs

adjuvant therapy

A

neoadjuvant- inital chemotherapy to shrink the tumour

adjuvant- surgery, followed by radiotherapy or chemotherapy

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14
Q

What is the patient advice surrounding ciclosporin?

A
  • Avoid live vaccines
  • Avoid excess UV light
  • Avoid high potassium diet and grapefruit juice
  • Warning signs about immunsuppression

Maintain brand

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15
Q

Tacrolimus can cause what kinds of organ damage?

A 
Nephrotoxicity
Cardiomyopathy
Neurotoxicity - headaches, tremors
Hepatotoxicity
Eye disorders- burred vision

Can also disturb glucose metabolism

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16
Q

What is the patient advice surrounding tacrolimus?

A

Avoid live vaccines

  • Avoid excess UV light
  • Avoid high potassium diet and grapefruit juice
  • Warning signs about immunsuppression

Maintain brand

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17
Q

What is a local reaction that can happen when IV cytotoxics are given?

A

Extravasation - severe local tissue necrosis

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18
Q

What are the main side effects of cytotoxics?

A
  • Alopecia
  • Nausea and vomiting
  • Oral mucositis - important to maintain good oral hygiene
  • Tumour lysis syndrome (due to destruction of malignant cells)
  • Hyperuricaemia - this is associated with acute renal failure. Give allopurinol/rasburicase
  • Bone marrow suppression apart from vincristine and bleomycin
  • Thromboembolism - cancer itself increases this risk too
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19
Q

What are the features of tumour lysis syndrome?

A

Hyperkalaemia, hyperuricaemia, hyperphosphataemia with

hypocalcaemia; renal damage and arrhythmias

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20
Q

How is acute nausea and vomiting symptoms managed in low risk chemotherapy patients?

A

Dexamethasone or lorazepam

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21
Q

How is acute nausea and vomiting symptoms managed in high risk chemotherapy patients?

A

5HT3 antagonist e.g. ondansetron + dexamethasone + aprepritant

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22
Q

What is used for prevention of anticipatory nausea and vomiting in chemotherapy patients?

A

Symptomatic control

Lorazepam can help

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23
Q

Which cytotoxic drug class has a high risk of cardiotoxicity and how is this prevented?

A

Anthracyclines - doxorubicine, epirubicine

An iron chelate derazoxane is given

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24
Q

What is given to counteract the folate-antagonist action of methotrexate in chemotherapy?

A

Folinic acid (calcium folinate)

This is also used in methotrexate overdose but does not work for antibiotics with anti-folate action e.g. trimethoprim

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25
Q

Mesna is given with what cytotoxic drugs and why?

A

Cyclophosphamide and ifosdamide

Prevents haemorhaegic cystitis as metabolites of the drugs cause a toxin (acrolein)

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26
Q

Cyclophosphamide and ifsfomide carry a risk of what?

What is done to prevent this?

A

Haemorrhaegic cystitis

MESNA is given to prevent urinary tract toxicity and increasing fluid intake for 24-48 hours after administration

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27
Q

What colour does doxorubicin turn your urine?

A

red

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28
Q

Do normal or liposomal formulations of doxorubicin carry a higher risk of cardiotoxicity?

A

normal formulation may carry a higher risk

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29
Q

What monitoring needs to be done before starting doxorubicin?

A

ECG due to the cardiotoxicity

Monitor during treatment too

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30
Q

What are the main side effects of bleomycin?

A
  • Hypersensitivity reactions
  • Progressive pulmonary fibrosis - monitor for suspicious X-ray changes
  • Respiratory failure
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31
Q

Should vinca alkaloids e.g. vincristine, vinblastine, be given IV or intrathecally?

A

Only ever IV
Intrathecal administration is
associated with severe neurotoxicity

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32
Q

What is the patient advice surrounding methotrexate?

A
  • Weekly dose not daily
  • The patient must report any signs of blood disorders i.e. sore throat, bruising, mouth ulcers), liver toxicity (i.e. nausea, vomiting, abdominal pain and dark urine) and respiratory effects (SOB).
33
Q

What are the serious side effects of methotrexate?

A
  • Immunosuppression and blood disorders
  • GI toxicity
  • Stomatitis - inflammation of mouth and lips
  • Liver toxicity
  • Pulmonary toxicity
34
Q

How is it recommended that methotrexate tablets are dispensed?

A

Single strength tablets only to avoid confusion, usually 2.5mg tablets

35
Q

What is the MHRA warning regarding the use of imatinib?

A

Can cause reactivation of Hepatitis B

36
Q

What are the pre-treatment screening requirements for methotrexate?

A

Exclude pregnancy before treatment

FBC, renal function and LFTs

37
Q

What needs to be monitored in a patient on methotrexate and how often?

A

Have full blood count and renal and liver function tests repeated every 1–2 weeks until therapy stabilised, thereafter patients should be monitored every 2–3 months

38
Q

What OTC medicines should a patient on methotrexate not have?

A

NSAIDs - aspirin, ibuprofen

Patients should be counselled on the use of NSAIDs

39
Q

True or false:

Penicillins increase toxicity risk of methotrexate

A

True

40
Q

How does allopurinol and azathioprine/mercaptopurine interact?

A

Azathioprine/mercaptopurine inhibits purine metabolism

Allopurinol also does this

Reduced dose is needed if given with allopurinol to reduce risk of toxicity

41
Q

What are the main side effects of mycophenolate mofetil (MMF) to look out for?

A

Bone marrow suppression

Hypogammaglobinaemia - measure serum immunoglobulin if experiencing recurrent infections

Bronchiectasis - Look out for cough, SOB

42
Q

What does the MHRA suggest for excluding pregnancy when starting mycophenolate MMF?

A

The MHRA advises to exclude pregnancy in females of child-bearing potential before treatment—2 pregnancy tests 8–10 days apart are recommended.

Pregnancy prevention programme

43
Q

What kind of juice should be avoided if on tacrolimus?

A

Grapefruit juice

44
Q

What is neoadjuvant chemotherapy?

A

Delivered before the main treatment e.g. to shrink the tumour

45
Q

What role does febuxostat play in chemotherapy patients?

A

Prophylaxis and treatment of acute hyperuricaemia

Started 2 days before chemo

46
Q

Rasburicase is used for the treatment of acute hyperuricaemia in what kind of cancer?

A

Blood cancers

47
Q

What is a common side effect of doxurubicin (more common with liposomal formulations)?

A

Hand-foot syndrome

May be prevented by cooling hands and feet and avoiding socks, gloves, or tight-fitting footwear

48
Q

What biomarker can you measure to see if you need to reduce the dose of doxorubicin?

A

Doxorubicin is largely excreted in the bile and an elevated bilirubin concentration is an indication for reducing the dose.

49
Q

What bags should vincristine and vinblastine go in for adults and teenagers to prevent it from being administered intrathecally?

A

50mL mini bag

Should also have a sticker on to say “For IV use only”

50
Q

What is the contraception advice for men and women on methotrexate?

A

Use effective contraception for at least 6 months after treatment

51
Q

What is the advice surrounding the use of ciclosporin and malignancies?

A

Like other immunosuppressants, ciclosporin increases the risk of developing lymphomas and other malignancies, particularly those of the skin.

In psoriasis, exclude malignancies (including those of skin and cervix) before starting

It is contraindicated in malignancy for non-transplant indications (can be used in UC, RA, psoriasis)

52
Q

Can chemotherapy prescriptions be on repeat?

A

No unless indicated by a specialist

Dose is dependent each time on a lot of factors e.g. blood count

53
Q

How is delayed nausea and vomiting symptoms managed in moderate risk chemotherapy patients?

A

Ondansetron and dexamethasone

54
Q

How is delayed nausea and vomiting symptoms managed in high risk chemotherapy patients?

A

Dexamethasone + aprepitant

Metoclopramide and rolapitant also licensed

55
Q

Is cyclizine used for nausea and vomiting in chemo patients?

A

No - it is not licensed

This is mainly used for post op and palliative care N+V

56
Q

Can metoclopramide be used in acute N+V in chemo patients?

A

No, only licensed in the delayed phase

57
Q

Is it recommended to have a chest X Ray before methotrexate treatment?

A

Not usually indicated

58
Q

What are the 3 UK cancer screening programmes?

A

Breast
Bowel
Cervical

There is no screening programme for prostate cancer because the PSA test is not reliable enough, but men over 50 can ask their doctor about it.

59
Q

Is there a screening programme for prostate cancer?

A

There is no screening programme for prostate cancer because the PSA test is not reliable enough, but men over 50 can ask their doctor about it.

60
Q

can methotrexate be given intrathecally

A

yes

61
Q

What is the bowel cancer screening programme e.g. age, what does the patient need to do, how often, what gender?

A

In England, people between the ages of 60 and 74 years take part.

Both male and female

Every 2 years

Send off a stool sample

You need to be registered with a GP to receive screening invitations

62
Q

What is the breast cancer screening programme e.g. age, how often, what does the patient need to do,?

A

50-70 years
In some areas this extends from 47 to 73 years

Every 3 years

Mammogram

You need to be registered with a GP to receive screening invitations

63
Q

What is the cervical cancer screening programme e.g. age, how often?

A

25-49 years every 3 years

49-64 years every 5 years

Need to be registered with GP

64
Q

Chemotherapy can cause Neutropenic sepsis, a MEDICAL EMERGENCY. This is essentially neutropenia. What are the symptoms?

A

General Malaise/ high temp above 37.5 (due to infection)

Shivering/ flu-like symptoms

Uncontrolled gum/ nose bleeds (due to low platelets)

Bruising

Mouth ulcers (worse than usual)

Diarrhoea/ uncontrolled vomiting (dont forget- chemo can cause some vomiting itself)

Advise patient to go to A&E asap and not to take paracetamol

65
Q

What are the Side effects of Chemotherapy?

A

Oral mucositis- inflammation of the mouth- ulcers and pain or difficulty swallowing.

Diarrhoea

Nausea and vomitting

Hyperuricaemia (high uric acid level)

Alopecia

dry mouth

Neutropenia

66
Q

Which two immunosuppressant drugs used in chemo have a lot of interactions, plus must always maintain the same brand?

A

Ciclosporin

Tacrolimus

67
Q

What is important to let patients know on therapy with Azathioprine?

A

Reporting- Blood disorders- sore throat, mouth ulcers, bleeding, fever- seek medical attention

68
Q

Tamoxifen is usually used for breast cancer at a dose of 20mg daily. It can increase the risk of another cancer: ______ cancer. It can also result in thromboembolism and patients are required to report symptoms like?

A

Endometrial cancer

Symptoms such as SOB, pain in one leg

69
Q

Which class of chemotherapy drug is Cardio toxic and associated with cardiomyopathy?

A

Anthracyclines eg

Doxorubicin

Epirubicin

Daunorubicin

70
Q

What drug is used as a protectorant from cytotoxic induced urothelial toxcitiy such as heamorrhagic cystitis/ blood in urine?

A

Mesna

71
Q

What would a high temperature following a dose of Chemo indicate?

A

Febrile Neutropenia

Remember neutropenia warning signs = fever- this is all it is

72
Q

When does bone marrow suppression, caused by most chemo drugs bar vincristine and bleomycin, usually occur?

A

7 -10 days after administration

73
Q

What is the MHRA advice surrounding the use of mycophenolic acid/MMF?

A

The MHRA advises to exclude pregnancy in females of child-bearing potential before treatment—2 pregnancy tests 8–10 days apart are recommended. Women should use at least 1 method of effective contraception before and during treatment, and for 6 weeks after discontinuation - 2 are preferredMycophenolate medicines remain contraindicated in women of childbearing potential who are not using reliable contraception and in pregnant women unless there are no suitable alternatives to prevent transplant rejectionMale patients or their female partner should use effective contraception during treatment and for 90 days after discontinuation.

74
Q

What is the MHRA advice surrounding the use of EGFR inhibitors e.g. cetuximab?

A

Keratitis and ulcerative keratitisIn rare cases, this has resulted in corneal perforation and blindness

75
Q

What OTC medicines should a patient on methotrexate not have?

A

NSAIDs - aspirin, ibuprofenPatients should be counselled on the use of NSAIDs

76
Q

True or false:Penicillins increase toxicity risk of methotrexate

A

true

77
Q

What kind of juice should be avoided if on tacrolimus?

A

Grapefruit juice

78
Q

What biomarker can you measure to see if you need to reduce the dose of doxorubicin?

A

Doxorubicin is largely excreted in the bile and an elevated bilirubin concentration is an indication for reducing the dose.

79
Q

What is the contraception advice for men and women on methotrexate?

A

Use effective contraception for at least 6 months after treatment

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