Immune System

Question 1

What type of T cells are CD4

Answer 1

Helper

Question 2

What type are CD8

Answer 2

Cytotoxic

Question 3

What are the self antigens

Answer 3

MHC

Question 4

Where are MHC1 found

Answer 4

All cells

Question 5

Where are MHC2 found

Answer 5

Dendritic cells

APCells

Question 6

MHC1 present

Answer 6

Endogenous proteins

Question 7

MHC2 cells present

Answer 7

Exogenous proteins

Question 8

Where are MHC 1 loaded

Answer 8

ER

Question 9

Where are MHC2 loaded

Answer 9

Phagolysosome

Invariant protein prevents binding at ER

Question 10

When are T cells activated

Answer 10

When TLR binds to MHC

Question 11

What cell recognizes MHC1

Answer 11

CD8

Question 12

What cells recognize MHC2

Answer 12

CD4

Question 13

What and when interacts directly with B cells

Answer 13

Helper T
When have antigens in MHC2
Stimulate proliferation

Question 14

What does T cell stimulate B cell to do

Answer 14

Colonial expansion

Memory helper T made

Question 15

What do cytotoxic t cells look for

Answer 15

Antigens in MHC1
Virus
Cancer
Hiding bacteria
Transfusion

Question 16

What do T cells release

Answer 16

Perforin

Granszyme

Question 17

What does Perforin do

Answer 17

Causes pore

Lysis

Question 18

What does granzyme do

Answer 18

Enter through pore

Signal apoptosis

Question 19

What is the function of regulatory T cells

Answer 19

Release cytokines
Suppress T and B cells
Protect gut bacteria
Protect fetus
Prevent autoimminity

Question 20

What is a congenital immunodeficiency

Answer 20

SCID
Deficit in B and T cells
Abnormal interleukins
Defective adenosine deaminase
Substances lethal to T cells build up

Question 21

What is hodgkins

Answer 21

Lymph node cancer

Immunodeficiency

Question 22

What are 2 opportunistic infections from aids

Answer 22

Pneumonia

Kaposis sarcoma

Question 23

What causes aids

Answer 23

Destroyed CD4

From HIV

Question 24

Examples of autoimmune disease

Answer 24

MS
Type one DM
Rheumatoid arthritis

Question 25

What 3 things cause autoimmune disease

Answer 25

Ineffective lymphocyte programming
new self antigens
Foreign antigens resemble self

Question 26

What causes new self antigens to appear

Answer 26

Mutation

Hapten attachment

Question 27

Type on allergy is mediated by

Answer 27

IGE

Immediate

Question 28

Type 2 allergy is mediated by

Answer 28

IgM
IgG
Cytotoxic
Agglutination

Question 29

Type 3 allergy caused by

Answer 29

Immune complexes
Precipitation
LPS

Question 30

Type 4 allergy caused by

Answer 30

T cells releasing cytokines
Delayed
Influx of macrophages

Question 31

How do mast cells produce inflammation

Answer 31

IgE antibodies on their surface

Release histamine when antigen binds

Question 32

What antibody region determines its class

Answer 32

C region

Question 33

What antibody is a pentameter

Answer 33

IgM

First antibody made

Question 34

What antibody is most found

Answer 34

IgG

memory

Question 35

What antibody can cross the placenta

Answer 35

IGg

Question 36

What antibody is in secretory fluid

Answer 36

IgA

Question 37

What antibody releases histamine

Answer 37

IgE

Question 38

What antibody is attached to B cells

Answer 38

IgD

Question 39

Describe classical pathway

Answer 39

Antibodies bind
Then complement
C1-C9

Question 40

Describe alternate pathway

Answer 40

Triggered by factors B D P

Question 41

What complement forms Mac

Answer 41

C3b

Question 42

What does C3b cause

Answer 42

Opsonization

Mac

Question 43

What does C3a cause

Answer 43

Inflammation