Immune System Flashcards

1
Q

What type of T cells are CD4

A

Helper

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2
Q

What type are CD8

A

Cytotoxic

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3
Q

What are the self antigens

A

MHC

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4
Q

Where are MHC1 found

A

All cells

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5
Q

Where are MHC2 found

A

Dendritic cells

APCells

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6
Q

MHC1 present

A

Endogenous proteins

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7
Q

MHC2 cells present

A

Exogenous proteins

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8
Q

Where are MHC 1 loaded

A

ER

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9
Q

Where are MHC2 loaded

A

Phagolysosome

Invariant protein prevents binding at ER

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10
Q

When are T cells activated

A

When TLR binds to MHC

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11
Q

What cell recognizes MHC1

A

CD8

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12
Q

What cells recognize MHC2

A

CD4

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13
Q

What and when interacts directly with B cells

A

Helper T
When have antigens in MHC2
Stimulate proliferation

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14
Q

What does T cell stimulate B cell to do

A

Colonial expansion

Memory helper T made

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15
Q

What do cytotoxic t cells look for

A
Antigens in MHC1
Virus
Cancer
Hiding bacteria
Transfusion
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16
Q

What do T cells release

A

Perforin

Granszyme

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17
Q

What does Perforin do

A

Causes pore

Lysis

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18
Q

What does granzyme do

A

Enter through pore

Signal apoptosis

19
Q

What is the function of regulatory T cells

A
Release cytokines
Suppress T and B cells
Protect gut bacteria
Protect fetus
Prevent autoimminity
20
Q

What is a congenital immunodeficiency

A
SCID
Deficit in B and T cells
Abnormal interleukins
Defective adenosine deaminase
Substances lethal to T cells build up
21
Q

What is hodgkins

A

Lymph node cancer

Immunodeficiency

22
Q

What are 2 opportunistic infections from aids

A

Pneumonia

Kaposis sarcoma

23
Q

What causes aids

A

Destroyed CD4

From HIV

24
Q

Examples of autoimmune disease

A

MS
Type one DM
Rheumatoid arthritis

25
Q

What 3 things cause autoimmune disease

A

Ineffective lymphocyte programming
new self antigens
Foreign antigens resemble self

26
Q

What causes new self antigens to appear

A

Mutation

Hapten attachment

27
Q

Type on allergy is mediated by

A

IGE

Immediate

28
Q

Type 2 allergy is mediated by

A

IgM
IgG
Cytotoxic
Agglutination

29
Q

Type 3 allergy caused by

A

Immune complexes
Precipitation
LPS

30
Q

Type 4 allergy caused by

A

T cells releasing cytokines
Delayed
Influx of macrophages

31
Q

How do mast cells produce inflammation

A

IgE antibodies on their surface

Release histamine when antigen binds

32
Q

What antibody region determines its class

A

C region

33
Q

What antibody is a pentameter

A

IgM

First antibody made

34
Q

What antibody is most found

A

IgG

memory

35
Q

What antibody can cross the placenta

A

IGg

36
Q

What antibody is in secretory fluid

A

IgA

37
Q

What antibody releases histamine

A

IgE

38
Q

What antibody is attached to B cells

A

IgD

39
Q

Describe classical pathway

A

Antibodies bind
Then complement
C1-C9

40
Q

Describe alternate pathway

A

Triggered by factors B D P

41
Q

What complement forms Mac

A

C3b

42
Q

What does C3b cause

A

Opsonization

Mac

43
Q

What does C3a cause

A

Inflammation