Immune signals Flashcards
B7/CD80
expressed on the surface of APCs
CCR2 CCL2
analogous to IL-8 for macrophages
CD15 + and CD16b+
Found on surface of neutrophils
CD19 and CD21+
on surface of b cells
CD14+ (TLR4)
found on surface of macrophages which binds to LPS
CD16+ CD56+
On surface of NK cell
CD19+ CD20+
on surface of B cell
CD23
has high affinity acer. on surface of mast cell
CS23a CD23b
Receptor for IgE that is found on mature B cells, activated macrophages, eosinophils, basophils, dendritic cells, mast cells
CD25+ CD4+
expressed on surface of Tregs that function to inhibit self-reactive Th1 cells in periphery
CD3+ CD4+
On surface of T helper cells
CD3+ CD4+ CD25+ IL-10 TGF-B
on surface of Treg
CD3+
on the surface of all types of T cells
CD80
On dendritic cells
GATA-1
required for terminal differentiation to eryhroid lineage
GATA-3
required for development of t lymphocytes
IFN-gamma
secreted by NK cells to activate macrophages
IL-1, IL-12, IL-23
chemokine that call M1 macrophages to site of inflammation
IL1, IL18
produced by NLRP3 inflammasome and causes potent inflammatory response. Capase-1 involvement
IL1 TNF
increase expression of P and E selections on endothelium to cause “rolling leukocytes”
IL1 TNF alpha and IL8
activate and call neutrophils
IL8
Caller of the neutrophils
IL10 TGFB
Chemokine that calls M2 macrophages to reduce inflammation
IL10
Anti-inflammatory. secreted by microphones, dendritic cells, and Tregs
IL12, IL15, Type 1 IFN
activate natural killer cells
IL4 and IL5
important for immunological response that involve IgE and eosinophils
IL4, IL5, IL10
produced by Th2 cells
IL4
leads to proliferation of IgE
IL5
will cause eosinophilic deletion of helminth invasion
IL4, IL13
Induces monocyte to become an M2 macrophage
IFN a
Interferon that inhibits viral replication by inhibition of protein synthesis. Produced by leukocytes
INF b
interferon that inhibits viral replication of protein synthesis. produced by fibroblast.
LFA 1
Found on neutrophils, macrophages, b cells and T cells. Binds to ICAM and is important in rolling response.
VLA 4
expressed on the surface of lymphoid progenitor cell that adheres to VCAM 1. promotes about interaction between the stem cell factor and kit leading to proliferation.
