Immune part II Flashcards
TACO(Transfusion-Associated circulatory overload
rapid plasma volume expansion
mostly seen in elderly with heart problem
Febrile non-hemolytic transfusion reaction treatment?
Hemolytic Transfusion reaction due to? Treatment?
treat with Acetaminophen (Coombs Neg)
ABO incompatibility (Coombs pos)
Stop transfusion and IV fluid
Both pre-form antibodies
HS? Antibody binds to FAB region of IgE on Mass cell causing degranulation
hypersensitivity 1
anaphylaxis
HS? Pernicious anemia, HIT, Rheumatic fever, M. Gravis
Bullus pemp. Hashimoto and Grave are examples of?
Type 2 HS
Antibody production against cells, tissues, receptor
Antibody-antigen complex and deposit EG:
PSGN
SLE
Arthus reaction
serum sickness
Polyarteritis nodosa
PPD, contact dermatitis, Graft vs. host dz
CD 4/8 T cell involved HS 4
Kill Vaccine ( A TRIPP could Kill you), causes humoral response MHC II
Hep A, Typhoid (IM), Rabies, Influenza (IM), Polio(Salk IM), Pertussis KILL
HPV: human papilloma V, HBV: Hepatitis B v. vaccines are
Recombinant
Diphtheria, tetanus vaccines are
Toxoid
MMR and varicella vaccines are given to HIV pt CD4 count
CD4 count above 200
Live-attenuated vaccines
My TRIP on Yellow Van
Yellow fever
varicella
rotavirus(oral
Influenza(intranasal)
Polio(sabin,oral)
MMR,
Typhoid (oral)
DX of Acute promyelocytic Leukemia: functional pancytopenia and
DX confirms with…
Auer rods: Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblast
fluorescent insiti hybridization(FISH)
What Duchene MD,
ornithine transcarbamylase def and
Fabry have in common
X-Linked
worse symptoms with Turner syndrome
Wiskott-Aldrich syndrome,
Ocular Albinism,
G6PD inheritance
x-linked
Becker MD,
Hemophilia A/B,
Lesch-Nyah,
Hunter syndrome,
Bruton X-LA
X-linked
which inheritance pattern will leave pt with Turner syndrome more susceptible than 46 XX,
Turner: monosomy X(45,X)
Comorbidity with any X-linked is problematic
colon cancer with numerous adenomatous polyps has a tumor suppressor gene?
genetic change affecting APC?
Mutation in KRAS and APC: increase cell entering S Phase
Proto-oncogenes: deletion or loss of function mutation leads to cancer
neonate with cataracts, PDA, thrombocytopenia purpura, sensory neural defects, large liver&spleen. preventions
Congenital rubella syndrome
live attenuated vaccine
57M + large nest mass, mix inflammatory cellularity with some large cells showing bilobed nucleus? CD marker?
Reed-Sternberg cell
CD 15/30
Hodgkin disease
Positive skew
neg skew
median represent the central tendency
mean>median
mean<median
elevated carnitine ester strongly suggests a defect in
Occurs in Mito matrix
fatty acid oxidation early step
Enzyme: VLCAD(very long-chain acyl-CoA dehydrogenase def
low carnitine ester in muscle and serum
primary carnitine defi
carnitine transporter
4M +fever, rash, urticaria, with hand, wrist, and knee pain. 10dy HT or URT infection. Treatment
Serum sickness reaction HS type 3
Treat with Anhihistamines & steroid
blue-green pigmented growth with a fruity smell
Exotoxin A
similar to?
P. Aeruginosa: G(-) oxidase-pos, aerobic rod, cat pos
stops EF-2 :protein synthesis
diphtheria
inguinal hernia strangulation caused by?
PE may show a reducible mass in the scrotum.
compromised vascular supply of bowel
HIT type 2 caused by antibody against heparin bound to platelet factor 4(PF4) treatment
Bivalirudin: direct thrombin inhibitor
direct hernia emerges through
the posterior wall of the inguinal canal
medial to inferior epigastric vessels
superior to the inguinal ligament
lateral to rectus abdominis
pleomorphic clear cells with cytoplasmic vacuoles, scallop nucleus with pos oil Red O stain
Liposarcoma
flagellated, encapsulated, gram neg rod producing HS
osteomyelitis in sickle cell pt
salmonella
rotavirus in HIV infected pt presents with
mono-like :fever sore throat, large lymph, spleen and liver
Lambert-Eaton affects
voltage-gated ion channels Ca2+
presynaptic
Erythema infectiosum (slapped cheek) + sickle cell =
aplastic crisis
B-19
