Immune Oncology Flashcards

1
Q

What’re the drug classes used in immuno-oncology?

A

Cytotoxic T-lymphocyte antigen 4 (CTLA4) inhibitor

Programmed cell death receptor-1 (PD1) inhibitor

PD-Ligand 1 (PD-L1) inhibitor

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2
Q

What is CTLA-4?

A

It’s a receptor found on the T-cell surface

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3
Q

How does CTLA-4 exert its effects in cancer?

A

Competes w/ T-cell CD28 receptors for binding B7 molecules on the cancer-antigen-carrying APC > reduces immune sys activity against cancer antigens (and cancer cells by extension)

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4
Q

CTLA-4 inhibitor MOA

A

Drug blocks CTLA-4 receptor on T-cell > prevents competition b/w CTLA-4 receptor and CD28 receptor for binding of tumor antigen on APC > increased immune response against tumor

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5
Q

What’s PD-1?

A

It’s a receptor found on T-cells

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6
Q

What’s PD-L1?

A

It’s a ligand found on cancer cells

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7
Q

What is our goal in cancer tx wrt PD-1 and PD-L1 receptors?

A

We don’t want the PD-1 receptor to bind the PD-LI of cancer cells bc that would prevent the T-cell from destroying the cancer cell

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8
Q

PD-1 inhibitor MOA:

A

Block PD-1 receptor of T-cell > blocks binding of cancer PD-L1 > increases rate of tumor cell death by immune sys

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9
Q

PD-L1 inhibitor MOA:

A

Block PD-L1 ligands found on cancer cells > prevent binding to PD-1 receptors on T-cells > increase immune sys activity against cancer cells

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10
Q

Ipilimumab is a…

A

CTLA4 inhibitor

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11
Q

Atezolizumab is a…

A

PD-L1 inhibitor

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12
Q

Avelumab is a…

A

PD-L1 inhibitor

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13
Q

Nivolumab is a…

A

PD-1 inhibitor

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14
Q

Pembrolizumab is a…

A

PD-1 inhibitor

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15
Q

What’s unique about lung cancer pts who receive chemotx?

A

They feel BETTER when receiving chemotx, unlike other cancer pts who feel worse (e.g. due to vomiting, anemia, thrombocytopenia, etc.)

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