Immune Hypersensitivities (Buxton) 2 hours, 6 questions

Question 1

Name the Antibody Class(es) involved in Type I Hypersensitivity

Answer 1

IgE

Question 2

Type I Hypersensitivity is known as:

Answer 2

Atopy , Immediate Hypersensitivity

Question 3

Name the three processes involved in the mechanism of hypersensitivity

Answer 3

sensitization
immediate reaction
late-phase response

Question 4

Antigen source in Type I hypersensitivity

Answer 4

Allergens

Question 5

Primary infiltrate of Type I hypersensitivity: (leaving blood coming into tissues)

Answer 5

Eosinophils + PMN leukocytes

Question 6

clinical manifestations of Type I hypersensitivity

Answer 6

Allergic Rhinitis(hay fever)
Food Allergies
Bronchial asthma
Anaphylaxis

Question 7

Cytokines involved in Type I Hypersensitivity:

Answer 7

TNF: increase vascular permeability

IL-4: promotes inflammation

Question 8

primary inflammatory mediators of Type I hypersensitivity

Answer 8

histamine
proteases
ECF (eosinophil chemotactic factor)
NCF (neutrophil chemotactic factor)

Question 9

secondary inflammatory mediators of Type I hypersensitivity

Answer 9

• secreted cytokines (TNF, IL-4)
• Leukotrienes (smooth muscle contraction + chemotactic factors)
• Prostaglandin (vascular dilation)

Question 10

mast cells

Answer 10

found in tissues (primarily in skin and mucosal membranes)

Question 11

pathogenesis of skin testing

Answer 11

1. allergen binds anti-allergen IgE on mast cells in skin
2. mast cell degranulation
3. histamine causes vasodilation and increased vascular permeability
4. results in erythema (flare) and localized edema (wheal- fluid filled bump on skin