Immune Evasion

Question 1

How does Salmonella evade the immune system?

Answer 1

• Flagellin protein - DNA inversion in promoter - actively switch one/other off

Question 2

How does neisseria gonohoreae evade the immune system?

Answer 2

Gene conversion of pili ~1,000,000 variants

Question 3

How do plasmodia evade the immune system? (2 points)

Answer 3

• Constantly change their surface glycoprotein - using gene conversion
• Change VSG’s - creates waves of infection

Question 4

How does Plasmodium falciparum evade the immune system?

3 points

Answer 4

• As they have complexed life cycles
• They hide/sequestering in red blood cells - (don’t have MHC1)
• Produce adhesive proteins - expressed on surface