Immune Checkpoint Inhibitors Flashcards
1
Q
atezolizumab
A
Tecentriq
anti PD-L1 monoclonal antibody
2
Q
avelumab
A
Bavencio
anti PD-L1 monoclonal antibody
3
Q
cemiplimab
A
Libtayo
anti PD-L1 monoclonal antibody
4
Q
dostarlimab
A
Jemperli
anti PD-L1 monoclonal antibody
5
Q
durvalumab
A
Imfinzi
6
Q
ipilimumab
A
Yervoy
anti-CTLA4 monoclonal antibody
7
Q
nivolumab
A
Opdivo
anti PD-L1 monoclonal antibody
8
Q
pembrolizumab
A
Keytruda
anti PD-L1 monoclonal antibody
9
Q
CTLA-4
A
CTLA-4 = cytotoxic T-lymphocyte associated antigen 4
- CTLA-4 is a down-regulator of T-cell activation pathways
- blocking CTLA-4 allows for enhanced T-cell activation and proliferation
10
Q
PD-L1
A
PD-L1 = programmed death ligand 1
- an immune check point protein expressed on tumor cells and tumor infiltrating cells
- down regulates anti-tumor t-cell function by binding to PD-1 and B7.1
- blocking PD-1 and B7.1 interactions restores antitumor t-cell function
