Immune cells

Question 0

What are Th2 cells?

Answer 0

CD4+ T-cells that activate B lymphocytes, stimulate Ab production
Also secrete IL-4, IL-5, IL-10

Question 1

What are Th1 cells?

Answer 1

CD4+ T-cells that activate macrophages, NK cells, cytotoxic T-cells Also secrete IFN-gamma, IL-2

Question 2

What are Th17 cells?

Answer 2

T-cells responsible for anti-parasitic and anti-fungal immunity
Also secrete IL-17 and IL-23
Detected and probably responsible for several autoimmune diseases

Question 3

What are T cytotoxic cells (CTL)?

Answer 3

CD8+ T-cells that kill cells infected with intracellular microbes and kills tumor cells

Question 4

What are Tregs?

Answer 4

Regulatory T-cells that down-regulate immune response

Also secrete

Question 5

What are the immune cells of innate immunity?

Answer 5

Macrophages, dendritic cells, natural killer cells (NK cells), neutrophils, basophils, eosinophils

Question 6

What are B-cells?

Answer 6

B lymphocytes responsible for antigen recognition and antibody secretion

Question 7

What are plasma cells?

Answer 7

B lymphocytes that only secrete antibody

Question 8

What is the mechanism of NK cells?

Answer 8

Nk cells are TCR/CD3 cells that resemble T-cells but don’t need priming or antigen presentation. NK cells can recognize cells that lose/reduce expression of MHC molecules. If no MHC, they kill MHC-low or negative cells (cancer cells, cells infected by virus)