IMIN Lec. 6

Question 1

What do receptors on lymphocytes recognize

Answer 1

Antigens

Question 2

What is unique about antigen receptors

Answer 2

they are clonally distributed, each with a unique receptor

Question 3

How are BCRs or TCRs activated

Answer 3

1. Antigen receptors associate with cellular signalling proteins
2. adjacent receptors pulled into aggregate
3. cross linking bridge->signal transduction with same transduced signal

Question 4

What kinds of antigen do B cells work on

Answer 4

3D, extracellular

Question 5

What kind of antigens can T-cells work on

Answer 5

Have to be represented by MHC

Question 6

Each B cell encodes ____BCR with unique _______

Answer 6

unique BCR, antigen specificity

Question 7

What stimulates B cell to produce antibodies?

Answer 7

Antigen,

cytokines, chemokines (2)

Question 8

An antibody is

Answer 8

Secreted BCR with identical antigen specificity to the antigen that stimulated it

Question 9

Antibody structure

Answer 9

2xlight chain

2xheavy chain, connected to each other by 2x disulphide bonds

Question 10

Light chains have _ V domains, _ C domain, compared to heavy chains

Answer 10

1, 1

1, 3 at least

Question 11

antibodies bind antigens through

Answer 11

variable regions of light and heavy chains

Question 12

V region
C region (in clones)

Answer 12

Varies between clones

Is conserved between clones

Question 13

Antibodies bind antigens by

Answer 13

reversible non-covalent interactions

Question 14

Epitope

Answer 14

parts of antigen recognized by antibody

Question 15

IgA

Answer 15

two IgA molecules joined by J chain, which facilitates transport of IgA across mucous
-also facilitates transfer of IgA to newborns

Question 16

IgD

Answer 16

vestigial receptor, replaced by IgA

Question 17

IgE

Answer 17

mast cell degranulation-allergic response

Question 18

IgG

Answer 18

monomer, binds+neutralizes toxins

Opsonization

Question 19

IgM

Answer 19

J chain, first antibody in mature B cells

important for complement pathway, seen early only

Question 20

ADCC

Answer 20

antibody dependent cellular cytotoxicity

Question 21

Antibodies bind antigens by

Answer 21

reversible non-covalent interactions

Question 22

Avidity

Answer 22

strength of multiple binding sites