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Immunology and Inflammation > IMI 1 > Flashcards

IMI 1 Flashcards

1
Q

PAMPs

A

Pathogen Associated Molecular Patterns

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2
Q

PAMPs

A

Pathogen Associated Molecular Patterns

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3
Q

PAMPs

A

Pathogen Associated Molecular Pattern

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4
Q

DAMPs

A

Danger Associated Molecular Patterns

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5
Q

Lipoteichoic acid is a PAMP found in - ?

A

Bacteria

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6
Q

Peptidoglycan is a PAMP found in - ?

A

Bacteria

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7
Q

Lipoprotein is a PAMP found in - ?

A

Bacteria

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8
Q

DNA is a PAMP found in - ?

A

Bacteria

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9
Q

Coat protein is a PAMP found in - ?

A

Viruses

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10
Q

Lipopolysaccharide is a PAMP found in - ?

A

Bacteria

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11
Q

DAMPs

A

Danger Associated Molecular Patterns

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12
Q

Lipoteichoic acid is a PAMP found in - ?

A

Bacteria

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13
Q

Peptidoglycan is a PAMP found in - ?

A

Bacteria

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14
Q

Lipoprotein is a PAMP found in - ?

A

Bacteria

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15
Q

DNA is a PAMP found in - ?

A

Bacteria

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16
Q

Flagellin is a PAMP found in - ?

A

Bacteria

17
Q

Lipopolysaccharide is a PAMP found in - ?

A

Bacteria

18
Q

Nucleic acid is a PAMP found in - ?

A

Viruses

19
Q

GPI (Glycosylphosphatidylinositol) anchor is a PAMP found in - ?

A

Parasites

20
Q

Zymosan is a PAMP found in - ?

A

Yeast

21
Q

5 PRRs are:

A
  1. Toll like receptors (TLRs)
  2. Nucleotide binding oligomerisation domain-like receptors (NLRs)
  3. C-type lectin receptors (CLRs)
  4. RIG-I like receptors (RLRs)
  5. Cytoplasmic DNA sensors (CDSs)
22
Q

What cell death leads to DAMP release?

A

Necrosis

23
Q

6 Phagocytic receptors are:

A
  1. Mannose receptor - CD206
  2. Scavenger receptors A and B
  3. Macrophage receptor with collagenous structure (MARCO)
  4. Lipopolysaccharide receptor - CD14
  5. Complement receptors 3 and 4 - CD11b/CD18
  6. Dectin-1
24
Q

TLR1/TLR2 heterodimer recognises - ?

A

Triacyl-lipopeptides

25
Q

TLR2/TLR6 heterodimer recognises -?

A

Diacyl-lipopeptides

26
Q

TLR3 recognises - ?

A

dsRNA in endocytic vesicles

27
Q

TLR4 recognises - ?

A

Lipopolysaccharides

28
Q

TLR5 recognises - ?

A

Flagellin

29
Q

TLR7 recognises - ?

A

ssRNA in endocytic vesicles

30
Q

TLR9 recognises - ?

A

Bacterial methylated CpG motifs on oligonucleotides

31
Q

Role of IL-1b

A

Vascular permeability

32
Q

Role of TNF-a

A

Vascular permeability

33
Q

Role of IL-6

A

Metabolises fat and muscle to increase body temperature

34
Q

Role of CXCL8

A

Recruits neutrophils to infected site

35
Q

Role of IL-12

A

Recruits and activates NK cells

36
Q

3 classes of NLRs

A
  1. NLRB - BIR domain
  2. NLRC - CARD domain
  3. NLRP - Pyrin domain
37
Q

What is pyroptosis?

A

Cell death caused by a high inflammatory state

Immunology and Inflammation (2 decks)

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