Imaging Flashcards

1
Q

What is an x-ray?
Relies on what, and damage it can cause?
Good for what?

A
  • ionizing radiation
  • MC imaging: film mainly replaced by digital sensors
  • relies on differential absorption: air, fat, water, bone densities
  • ionizing radiation can damage tissue: developmental issues, cancer
  • good for lungs, kidney/gall stones, bonesL anywhere there are air/fluid contrasts, or bone/soft tissue contrasts
  • not as good for soft tissues and brain, pathology can be hidden by normal structures
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2
Q

Best imaging options for bone lesions?

A
  • x-rays: most valuable initial imaging:
    look at nature of bone matrix
    look at interface of lesion and bone
  • most lesions at metaphysis near growth centers
  • benign: well defined, no cortical destruction or periosteal reaction
  • malignant: ill-defined, destructive, infiltrative, lytic or blastic
  • CT: best for eval subtle bone changes: good for areas hard to see on plain films
  • MRI: better for soft tissue and infiltrative marrow lesions
  • Bone scans: show metabolic activity, looking for mets:
    PET/CT beoming imaging of choice
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3
Q

DDx bone lesions?

A
- in general: 
trauma, benign lesions
infection, inflammatory condition
- aggressive bone lesions:
mets 
primary malignant bone tumor
infection
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4
Q

What is a fluoroscopy? Pros and Cons to this?

A
  • cont. x-rays used to obtain real time moving images of internal structures (GI studies)
  • can use to help guide fine needle bx
  • prolonged procedures can lead to skin burns
  • small cancer risk
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5
Q

What are upper GI studies?

A
  • barium swallow + fluoroscopy
  • contrast allows for exam of esophagus, stomach, and duodenum
  • eval of ulcers, GERD, vomiting, blood loss, hiatal hernia
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6
Q

What is a CT scan?

A
  • x-rays taken in several planes are computer processed to show images in mult. slices: AP, lateral, sagittal, x-section, and even 3D
  • part of PET and SPECT scans
  • subject to artifacts and distortion
  • best images with hgihest doses of radiation
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7
Q

Advantages of CT scans?

A
  • greater detail than regular x-rays
  • can diff structures of close physical density
  • eliminates superimposition of organs
  • show calcified and hemorrhagic lesions
  • can be shown in multiple planes or even as 3D image
  • good in neoplastic disease:
  • in abdomen in staging
  • good for eval of masses in chest
  • virtual colonoscopy - screening for colorectal tumors
  • most intracranial neoplasms are visible on CT
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8
Q

Downsides of CT scans?

A
  • risk of cancer (may increase as CTs are used more)
  • radiation dose of abdominal CT = 200 CXRs
  • 0.4% of cancers in US due to CT
  • worse in kids and immunocompromised pts

when contrast agents used:
-allergic rxns: 1-3% non-ionic and 7-12% ionic contrast agent
-anaphylaxis: old ionic agents 1%, now 2-30/mill
contrast induced nephropathy: 2-7%
- expensive
- observer variation

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9
Q

What is a pancoast’s tumor?

A
  • extension of tumor at apex of lung involving C8, T1, T2, nerves and possible destruction of ribs
  • shoulder pain radiating in ulnar distribution
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10
Q

How is a virtual colonoscopy done? Downside?

A
  • usually done with CT, but can be done with MRI also
  • reqrs bowel prep like colonoscopy
  • no need for sedation, quick recovery: injection of butylscopolamine (antispasmodic)
  • not as sensitive as colonoscopy
  • can’t do bxs
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11
Q

When are 3D reconstructions used?

A
  • when planning local resection
  • excellent for eval of bony architecture
  • helpful in eval bony integrity, alignment and stability
  • preop planning for sites of fixation and reconstruction - 3D CT
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12
Q

What is a mammography?

A
  • uses low energy x-rays to generate images
  • normal breast has masses, not homogenous
  • look for masses, asymmetries and micro-calcification
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13
Q

What do you do with an abnormal mammogram?

A
  • needs breast exam by skilled clinician
  • further mammography to confirm if finding is real
  • additional imaging tests - US - for better definiton
  • BIRAD classification helps with further testing/f/u
  • can use MRI with gadolinium - implants, very dense tissue
  • needle or surgical bx may be recommended
  • tissue dx is key for planning tx
  • most mammogram abnormalities are not cancer, most are due to benign changes
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14
Q

What are nuclear scans?

A
  • radio-isotope is injected IV: usually technitium 99m, occasionally gadolinium
  • 3 hrs later pt is scanned with gama camera
  • provides 2d image, PET and SPECT provide 3D
    these can be combined with CT and MRI
  • fxnl test: measures bone metabolism or remodeling
  • half of material goes to bones - osteoblasts: shows fractures, infections and most tumors, lytic tumors may not trigger a healing response - not seen
  • radioactive material is eliminated through the kidneys
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15
Q

Use of bone scans?

A
  • show increased metabolic activity or increased blood flow
  • assess activity of known lesions, find unknown lesions
  • sensitive test that can overestimate lesions
  • marrow replacing tumors (MM) are cold until cortical disruption occurs
  • bright spots are either arthritis or mets
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16
Q

How do PET scans work?

A
  • Positive emission tomography
  • usual tracer is fludeoxyglucose (FDG)
  • CT xray usually performed in same sitting
  • can be combined with CT, MRI to create 3D images
  • esp useful in lymphomas and lung cancers
  • FDG collects in highly metabolic tissue: detects active, rapidly growing tumors, used to detect mets
  • dramatically displayed in scans
  • higher grade malignancies detected more than benign processes: low grade cartilage lesions underestimated, hard to diff benign and low grade malignant lesions
  • PET compared to 99 Tc (bone scan): 91 vs 75% sensitivity for cancer, 96 vs 95% for specificity
  • expanding role in assessing response to cancer tx
  • can affect care in about 1/3 of pts with cancer
17
Q

What is a SPECT scan?

A
  • single photon emission computer assisted tomography: high resolution + accurate localization
  • gamma/nuclear camera (bone scan) + CT scanner:
    thallium, technetium, iodine, gallium isotopes used, emit gamma radiation that is measured directly
  • good for small spinal lesions: osteoid osteoma and osteoblastoma
  • more expensive than bone scans (insurance companies may require authorization)
18
Q

What are MRIs?

A
  • magnetic resonance imaging
  • powerful magnets excite H protons to emit measurable electromagnetic radiation
  • extremely sensitive imaging:
    shows soft tissue as well as bone, distinguishes grey from white matter in the brain
  • oscillating coils switched on/off rapidly - characteristic noise
  • many ways of presenting info: T1 and T2 imaging (diff pulse sequences), 3D reconstructions
  • advanced MRI techniques: angiography, fxnl MRI, diffusion MRI, CSF dynamics
19
Q

Downsides to MRIs?

A
  • expensive, slow
  • claustrophobia
  • pacemakers, stents
  • small metal fragments
  • metal artifact
  • need calm pt
  • may be genotoxic
20
Q

What MRI pulse sequence is better at detecting tumors and infarcts of the brain?

A
  • T2
21
Q

MRI vs CT of the brain?

A
  • skull gets in the way of xray imaging

- bone scatters x-rays much more than soft tissue, MRI radio waves pass unimpeded through bone (MRI is superior)

22
Q

What can you see on an MRI of the spine?

A
  • radiation free
  • superior for soft tissue imaging
  • can see subtle differences
  • L3-4 discitis - loss of disc space
  • reactive edema in vertebrae
  • gadolinium assists in delineating surrounding vascularity
23
Q

What is an US and how does it work?

A
  • high frequency sound waves: produced by piezoelectric transducer
  • reflect and echo off tissues: received in transducer
  • processed in ultrasonic scanner: turned into digital image
  • usually seen as 2D image, also movement over time, blood flow, location of blood, tissue stiffness, 3D
24
Q

Pros and cons of an US? Imaging modality of choice for?

A
  • cheap, quick, easy, safe, comfortable, shows solids and fluids, muscle, tendon, bone surface
  • hampered by bone, air, fat, very operator dependent
  • imaging modality of choice for thyroid tumors/lesions
  • can use to supplement mammography
25
Q

How do you make the dx of a tumor?

A
  • tissue is the issue
  • may need open bx
  • may be able to do needle bx: CT, fluoroscopic, or US guidance
26
Q

FNB of lung lesions?

A
  • use for peripheral lesions, dx yield: 90-97%
  • outpt procedure: 22 gauge needle
  • image guidance: fluoroscopy, CT, US
  • lung bx: may lead to pneumothorax (10-30%), hemoptysis (30%)
27
Q

What should you look for on spine imaging for mets?

A
  • breast, prostate, lung and kidney go to bones
  • early spine mets usually seen at base of pedicle -
    will see unilateral destruction of pedicle - winking owl sign
  • early on xrays are of limited use
28
Q

Of those who presented with isolated back pain - and had abnormal xrays of spine - what primary cancers were the main culprits?

A

spine:

  • met from breasts (94%)
  • lungs (74%)
  • lymphoma (40%)
29
Q

Most common spot on spine for tumor to cause neuro compromise?

A
  • 70% lesion in vertebral body
  • 10% lesion in posterior elements
  • disc isn’t usually involved (unlike infections that thrive in avascular areas)
30
Q

What imaging modalities can you use to assess response to tx?

A
  • bone scan, CT, PET
31
Q

What imaging modality is best predictor of survival after cancer Rx?

A
  • PET scans

- if PET scan is negative after therapy, the tumor is likely to be dead at time of surgery

32
Q

Causes of pathologic fractures?

A
- occur through area of weakened bone:
osteoporosis
benign cystic tumor
malignant tumor
- when tx fracture always assess the bone!
33
Q

Pros and cons of x-rays?

A
  • pros: simple, inexpensive, readily available, easily interpreted
  • ## cons: radiation, poor tissue contrast, technician dependent, in 2D
34
Q

Pros and cons of CT scan?

A
  • pros: rapid, 3D capability, axial imaging, good bony detail
  • cons: highest radiation, motion and metal artifact, limited ST contrast
35
Q

Pros and cons of bone scans?

A
  • pros: images metabolic activity, very sensitive in bones, low cost
  • cons: non-specific, poor detail, anatomic changes not visualized
36
Q

Pros and cons of MRI?

A

pros: superior tissue resolution
cons: expensive, motion, and metal artifact, can’t use in some pts (metal fbs)

37
Q

Pros and cons of PET/CT or PET/MRI?

A
  • pros: combines fxn and anatomy, best imaging for most cancers
  • cons: expensive (pre-authorization from insurance)
38
Q

Pros and cons of US?

A
  • pros: very safe, inexpensive, and quick

- cons: small field of view, technician and radiologist dependent, artifacts