IM mix UWQ - may30th 2021 Flashcards
chemotherapy at risk for opportunistic pathogens?
gram-negative bacillus Pseudomonas aeruginosa.
-> ecthyma gangrenosum
Pyoderma gangrenosum
sym?
neutrophilic dermatosis
-> seen with IBD and arthropathies.
dev rapidly –> begin as a cutaneous papule/nodule–> quickly matures into a painful, purulent ulcer with violaceous borders.
lose weight to achieve and maintain a healthy weight.
rx?
each 10 kg (22 lb) of weight loss can lower blood pressure by ~6 mm Hg;
-> weight loss is one of the most effective nonpharmacologic interventions
Pain in the groin, buttock, or lateral hip (trochanteric) region and can radiate to the lower thigh or knee.
- > mild pain and brief stiffness with prolonged rest <30 mins
- .> worst pain usually occurs with activity and weight bearing
dx?
XR finding?
osteoarthritis of the hip
x-ray:
loss of joint space, osteophyte formation, and subchondral sclerosis.
loc: Knees Hips DIP joints 1st carpometacarpal joint
Lower back pain
rx?
acute <4 weeks: moderate exercise, NSAIDS
subacute/ chronic >12 wks:
exercise rx, TCA, duloxetine
secondary prevention: exercise therapy, education
Vs/ back brace not useful for preventing LBP
high dose drug prolong use>3 month
Constitutional symptoms (eg, fever, malaise)
Arthralgias
Serositis (eg, pleuritis, pericarditis)
Rash (less common compared with SLE)
Dx?
rx induced?
Drug-induced lupus erythematosus
procainamide, hydralazine, penicillamine
Others:
minocycline,
TNF-α inhibitors (eg, etanercept, infliximab),
isoniazid
RF: slow acetylator status
Hypertrophic osteoarthropathy
sym?
- > underlying lung disease (eg, adenocarcinoma, chronic pulmonary infection)
- > arthralgia.
- > skin thickening and digital clubbing
Microscopic polyangiitis and granulomatosis with polyangiitis
(wegener)
-> necrotizing, small-vessel vasculitides
sym?
lab?
- > acute-onset fever
- > tracheopulmonary disease.
- > rhinosinusitis, hematuria, and rash (eg, palpable purpura)
- > saddle nose , hearing loss
lab: c-ANCA: PR3+, MPO+
Osteogenesis imperfecta
defective formation of type 1 collagen,
- > bone, tendons, ligaments, skin, teeth, and sclera.
- > childhood with fragility fractures, short stature, impaired hearing, blue sclera
osteomalacia
-> fatigue, bone pain, and hypophosphatemia
lab?
Asso with: celiac dx, CKD, Chronic liver dx, bypass surgery
↑ Alkaline phosphatase ↑ PTH ↓ Serum calcium & phosphorus ↓ urinary calcium ↓ 25 OH-D levels
X-rays: thinning of cortex with reduced bone density
-> reduced mineralization of the osteoid matrix
Bilateral & symmetric pseudofractures (Looser zones)
amiloride
moa?
sym?
rx?
potassium-sparing diuretic that blocks the epithelial sodium channel (ENaC) in the renal collecting system.
sym:
hyperkalemia
met acidosis
rx: switch rx -> CCB recheck in 1-2 wks
severe hyperkalemia rx:
IV ca + insulin + glc
Goodpasture syndrome)
sym?
hx?
hx:
anti–glomerular basement membrane (anti-GBM) disease
renal bx: formation of antibodies to the alpha-3 chain of type IV collagen
-> linear IgG deposition along the glomerular basement membrane IF
sym:
1. renal : pnuria <3.5g/day, hematuria
2. resp: hemoptysis , SOB
PCP
sym?
HIV patients with CD4 counts <200/mm3.
- > Fever, dyspnea, and nonproductive cough
- > Fatigue, weight loss, and chills
acute-onset, severe headache
vomiting, photophobia, neck stiffness, and lethargy
dx?
Rx?
subarachnoid hemorrhage (SAH) -> ruptured saccular aneurysm
isolated CN palsies -> sign of a compressing aneurysm: Oculomotor nerve (CN III) palsy -> pupillary dilation: loss of PNS, ptosis and down and out due to loss of somatic innervation.
Full or partial oculomotor nerve palsy: enlarging or ruptured aneurysm of the adjacent PCA
Dx: CT angiography
Cavernous sinus thrombosis
sym?
fever, headache, and periorbital swelling.
-> palsy of ICA, CNs III, IV, and VI , V1, v2 resulting in ophthalmoplegia.
JC virus reactivation
untreated AIDS
dx?
Progressive multifocal leukoencephalopathy
MRI:
asymmetric white matter lesions;
no enhancement/ edema
Community acquired pneumonia (CAP)
- > pulmonary parenchymal infection, focal consolidation
sym: develop acutely and include fever, cough, pleuritic chest pain, and dyspnea. - > Tachycardia, tachypnea, focal crackles (right lower lobe)
dx?
> caused by bacterial (majority), viral (30%), or fungal pathogens.
-> strep pneumonia
dx: CXR
- > Symptomatic treatment alone insufficient due to the risk of secondary bacterial pneumonia
chronic pancreatitis
CT: pancreatic atrophy and calcifications
RF: smoking + Etho
rx?
destruction of acinar and islet cells
-> pancreatic exocrine insufficiency.
Pancreatic secretion is stimulated by cholecystokinin (CCK).
Normally, pancreatic enzymes breakdown CCK-releasing protein, thereby limiting CCK release.
pancreatic insufficiency, pancreatic enzyme deficiency
- > release of high volumes of CCK
- > pancreatic hyperstimulation
rx:
Pancreatic enzyme supplementation, lipase, protease, and amylase
obstructed pancreatic duct
dx?
Endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy and/or stent placement
burning or itching of the lids, discharge (which may be associated with crusting of the eyelashes in the morning),
- > often a foreign body sensation in the eye
- > scaling at the lid margin
Dx?
Blepharitis
-> inflammation at the eyelid margin, usually most prominent at the opening of the meibomian glands.
Asso with:
seborrheic dermatitis
Allergic conjunctivitis
sym?
conjunctival edema
-> prominent (often with papilla formation)
primarily at the conjunctivae rather than lid margin,
Asso with:
seasonal allergies or other atopic disorders.
TCA overdose
- > anticholinergic effects (eg, hyperthermia, flushed skin, dilated pupils, decreased bowel sounds)
- > seizures
- > cardiac toxicity (eg, prolonged QRS interval, hypotension)
antidopt?
Hypotension is treated with isotonic saline boluses;
refractory hypotension may require vasopressors (eg, norepinephrine)
->IV NaHco3:
decreases the incidence of ventricular arrhythmia
anticholinesterase toxicity
sym?
antidopt?
Atropine and pralidoxime
sym:
- > cholinergic toxicity
-> bradycardia, miosis, and salivation.
Hyperkalemia
-> peaked T waves, followed by lengthening of the PR and QRS intervals, and eventually resulting in a sine wave.
-> Bradycardia and muscle weakness
rx?
Calcium gluconate
Systemic sclerosis:
severe hypertension and acute renal failure
-> scleroderma renal crisis
Thrombocytopenia and microangiopathic hemolytic anemia
rx?
renal ischemia
-> activation of the renin-angiotensin-aldosterone system (RAAS).
rx: ACEi
elevated serum creatinine level is not a contraindication for ACE inhibitors
Hemodialysis
-> Urgent indications hyperkalemia, volume overload with respiratory impairment
multiple sclerosis
-> neurologic symptoms (eg, weakness, incontinence)
rx?
interferon beta-1a
MDD
-> anhedonia, feelings of worthlessness, weight loss, low energy, impaired ability to think) accompanied by memory impairment
rx?
depression-related cognitive impairment
rx:
- > selective serotonin reuptake inhibitors (eg, escitalopram)
-> psychotherapy.
AD
rx?
- > Cholinesterase inhibitors (eg, donepezil)
- > NMDA receptor antagonist memantine
treatment of dementia (eg, Alzheimer disease)
-> congenital narrowing of the descending aorta, just distal to the left subclavian artery.
creates a proximal arterial pressure load affecting the upper body
dx?
Coarctation of the aorta
- > Congenital
- > Acquired (rare) (eg, Takayasu arteritis)
- > hypertension
- > continuous murmur
- > S4
CXR:
notching of the posterior third of the third to eighth ribs
-> bony erosion due to enlarged intercostal arteries.
Upturning of the cardiac apex (“boot-shaped heart”)
dx?
tetralogy of Fallot due to pulmonic stenosis and consequent right ventricular hypertrophy.
Diffuse vascular calcifications
dx?
premature ATS with advance renal failure
Prominent right atrial contour
dx?
Ebstein congenital abnormality
-> apical displacement of the tricuspid valve with atrialization of the right ventricle
MM
-> back pain, normocytic anemia, and arm pain
Hx?
dx?
Osteolytic lucent lesion
Dx:
serum pn electrophoresis , M spike
bone marrow biopsy confirm
warning signs consideration of early imaging:
- Neurologic findings: Seizure, changes in consciousness, specific deficits
- Differences compared to prior headaches: Change in frequency, intensity, characteristics
- Other: New at age >40, sudden onset, trauma, present on awakening
Dx?
Dx: MRI
- > lymphoplasmocytic malignancy
- > excessive production of monoclonal IgM antibody.
sym:
- > hyperviscosity syndrome (diplopia, tinnitus, headache, dilated/segmented funduscopic findings),
-> neuropathy (electric sensation), infiltrative disease (hepatosplenomegaly, anemia, thrombocytopenia)
dx?
Waldenstrom macroglobulinemia (WM
dx: monoclonal spike (M-spike) of IgM
- > bone marrow biopsy showing >10% clonal B cells
Multiple myeloma (MM)
lab?
monoclonal IgG, IgA, or light chains
-> CRAB
bone pain
Psoriatic arthritis (PsA)
sym?
X-ray:
narrowing of the proximal phalanx with erosion of the distal phalanx (pencil-in-cup deformity) and new bone formation
cyclical/episodic
–> rather than chronic/slowly progressive.
- > Prolonged (>30 min) morning stiffness and pain lessen, not worsen, with activity.
- > involves the DIP and PIP joints;