IM Flashcards
Amiodarone sfx and how to monitor
Pulmonary toxicity - interstitial pneumonitis, ARDS
Obtain CXR and PFTs at baseline
S4 indicates
stiff/hypertrophied ventricle
DDX
- acute MI
- HTN
- aortic stenosis
- hypertrophic cardiomyopathy
rheumatic heart disease murmur
mitral stenosis
aortic stenosis
what should you avoid giving someone on cocaine?
beta blocker
aortic dissection treatment/management
1) pain control
2) beta blocker
3) Na nitroprusside
Dihydropyridine Calcium Channel Blocker sfx
and how to reduce it
sfx = peripheral edema
treatment = ACEi/ARB
What should be avoided in treatment of an Acute MI that becomes Flash Pulmonary Edema?
Avoid beta blockers in the presence of flash pulmonary edema
Tx =
- ASA, Clopidogrel
- Statin
- Loop diuretic
EKG:
High voltage QRS
Lateral (v5-v6) ST depression
Lateral (v5-v6) T inversions
LVH
Treatment of beta blocker overdose
presentation = bradycardia, hypotension, AV block, diffuse wheezing, seizures, cardiogenic shock
treatment =
1) Airway
2) Isotonic fluid bolus
3) IV atropine (to fix bradycardia and hypotension)
4) IV glucagon
Nitroprusside sfx
Cyanide toxicity
- occurs when pt is receives high doses or if someone has renal failure (elevated Cr)
- symptoms = AMS, lactic acidosis, seizures, coma
When do you give IVIG for tetanus prophylaxis?
If un-immunized or received <3 toxoid doses or patient unsure AND large/dirty wound
What is the CD4 cut off for receiving live vaccines?
Patients with CD4<200 should not receive live vaccines
- MMR
- VZV
- oral polio
- nasal influenza
- rotavirus
- yellow fever
Malaria prophylaxis
- Mefloquine - starts before, throughought ends after return
- Atorvaqone-Proguanil
- Doxycyline
Osteomyelitis - which two bacteria?
Staph aureus
Pseudomonas
Young + HTN + Diuretic-induced hypokalemia
Primary hyperaldosteronism (Conn)
Polydipsia + Polyuria DDX (5)
- DM
- Diuretic use
- Central DI (serum Na elevated)
- Nephrogenic DI (serum Na normal)
- Primary polydipsia (serum Na low)
What does a positive Prussian blue stain indicate?
positive hemosiderin (indicates hemolysis)
cirrhosis + ascites + low grade fever + abdominal discomfort + altered mental status =
tx
SBP
-fluid is positive if there are >250 PMNs or >500 WBCs
tx = IV Abx
-3rd generation cephalosporins to cover gram negative (EColi, Klebsiella) and gram positive (Enterococcus)
What does OCP induced liver damage look like in lab and biopsy
Lab = abnormal LFTs
Biopsy = no evidence of necrosis or fatty changes
IgA Nephropathy vs Post-Streptococcal Nephropathy
IgA Nephropathy = 5 days post-URI, normal compliment
Post-Streptococcal Nephropathy = 10-14 days post-URI/pharyngitis, low compliment (C3)
What lab value indicates saline responsive metabolic alkalosis?
What lab value indicates saline resistant metabolic alkalosis?
Saline responsive: urine Cl <20
tx = NS MIVF + K
Saline resistant: urine Cl >20
tx = spironolactone
COPD treatment with maximal impact on mortality
- smoking cessation
- home O2
Treatment of an acute exacerbation of COPD (5)
- O2 (target SpO2 88-92%)
- inhaled bronchodilators
- systemic glucocorticoids
- antibiotics (if there are >2 symptoms)
- NPPV if respiratory failure
woman + chronic dry cough + malaise + bilateral hilar lymphadenopathy =
Sarcoidosis (Chronic Granulomatous Inflammation)
What 3 cancers can cause malignant pleural effusions?
- Lung ca
- Breast ca
- Lymphoma
“dysmorphic RBC on the urinalysis”
Goodpasture’s disease
treatment for spinal cord compression
1) IV glucocorticoids
2) MRI
elevated homocystiene + DVT or history of DVTs
What to do next?
Give pyridoxine
Pyridoxine, Vit B12, Folate are required for the metabolism of homocystiene
treatment for Cancer Related Anorexia/Cachexia Syndrome (CACS)
- progesterone analogues
- corticosteroids
sfx of Epo therapy (4)
- worsening HTN
- headaches
- flu-like symptoms
- red cell aplasia
treatment of organophosphate poisoning
1) Atropine
2) Take off all clothes and wash body
how to dx arsenic poisoning
urine level
“variant lymphocytes with large vacuolated cytoplasms”
atypical lymphocytes of EBV
pneumaturia occurs in what disease?
pneumaturia = air in urine
Occurs in colovesical fistulas in Diverticular disease, Chrons, Malignancy
4 main substrates of gluconeogenesis
- alanine (-> pyruvate)
- glutamine (-> Krebs)
- Lactate (-> pyruvate)
- glycerol-3-phosphate (-> glucose)
young patient (<55 yo) with unexplained heart block or unexplained ECG changes
Cardiac sarcoidosis
Hodgkin’s lymphoma treated with chemo + radiation before the age of 30 increases your risk for _
a secondary malignancy
Lung, Breast, Thyroid, Bone, GI, Acute leukemia, NonHodgkin’s
wedge shaped infarct + pleuritic chest pain + hemoptysis =
PE
what two drugs to avoid in an asthmatic who just had an MI
- ASA
- Beta blocker
may trigger bronchoconstriction
a firm, non-tender, solitary lymph node in the head/neck is most likely _
squamous cell carcinoma
elderly patient + severe lymphocytosis + hepatosplenomegaly + lymphadenopathy + anemia + thrombocytopenia =
CLL
- elevated lymphocytes
- low platelets
- low Hgb
JAK2 mutation is associated with _
Myeloproloferative disease/ Polycythemia Vera
Lab values in tumor lysis syndrome and its consequences (2)
elevated uric acid
elevated K
elevated P
low Ca (because the elevated P binds to Ca)
Arrythmias due to elevated K
AKI due to uric acid deposition
epitrochlear lymphadenopathy is pathognomonic for _
Syphilis
- gray mucous patches
- maculopapular rash taht spreads from the trunk->out (including palms and soles)
- diffuse lymphadenopathy
sudden onset RUQ pain + fever + vomiting + leukocytosis =
acute cholecystitis
stone in cystic duct
CT scan - pulmonary nodule surrounded by ground glass opacities
Halo sign
-Invasive aspergilosis
after an endoscopy a patient gets L sided small pleural effusion + acute chest pain + subcutaneous emphysema =
esophageal perforation
-gastrograffin swallow to dx
mechanism of HTN in thyroid disease
- Thyrotoxicosis/Hyperthyroid =
- Hypothyroid
Thyrotoxicosis/Hyperthyroid = HTN, tachycardia, wide pulse pressure
+inotropic
+chronotropic
decrease in systemic vascular resistance
Hypothyroid = HTN
increase in systemic vascular resistance
First step when you find a thyroid nodule
1)TSH + ultrasound
elevation of L mainstem bronchus on CXR indicates
L atrial enlargement
-MS
mineral deficiency
- brittle hair
- skin depigmentation
- peripheral neuropathy
- ataxia
- sideroblastic anemia
- osteoporosis
Copper
mineral deficiency
- alopecia
- pustular skin rash
- hypogonadism
- impaired wound healing
- impaired taste
- immune dysfunction
Zinc
mineral deficiency
- hyperpigmented rash
- diarrhea
- dementia
Niacin (vit B3)
“Pellagra”
RBC casts
glomerulonephritis
WBC casts (2)
- interstitial nephritis
- pyelonephritis
broad/waxy casts
chronic renal failure
What type of kidney stones are seen in someone with fat malabsorption disease
Calcium oxalate stones
Normally, calcium binds to oxalate in the gut to prevent its absorption
Fat Malabsorption diseases, there is increased fat in the gut that binds up calcium therefore leaving less calcium to bind with oxalate therefore the oxalate is absorbed and then secreted into the urine
Glomerular disease associated with lymphoma
minimal change disease
Glomerular disease associated with solid cancers
membranous glomerulonephritis
ASO titers are used to diagnose =
recent strep pharyngitis
NOT infectious endocarditis
DDX pulus paradoxicus (3)
- Cardiac tamponade
- Asthma
- COPD
fluids used to resuscitate (fix volume status)
Normal saline (0.9% NS)
fluids used to fix hypernatremia
1/2NS + D5
diastolic sound with a squeaking quality at L sternal border
pericardial friction rub
How to know if someone is adequately compensated in their metabolic acidosis?
Winters Formula
compensated PCO2 = 1.5 (HCO3) + 8 +/- 2