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Infectious Mononucleosis > IM > Flashcards

IM Flashcards

1
Q

Other name of infectious mononucleosis

A

Torrid/French Kissing Disease or Glandular Fever

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2
Q

Most common transmission of IM

A

Exchange of saliva through kissing

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3
Q

What kind of virus is IM?

A

DNA Virus

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4
Q

The infection that is most common during the adolescent stage and early adulthood in women

A

Epstein Barr Virus

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5
Q

EBV infects what type of lymphocyte?

A

B-lymphocyte

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6
Q

EBC inhabits at?

A

nasopharyngeal tissues

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7
Q

EBV can be asymptomatic?
True or False

A

True

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8
Q

Other name of Downey cells

A

Atypical or reactive lymphocyte

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9
Q

Enlarged lymphocytes affected by EBV with characteristics atypical nuclei

A

Downey cells

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10
Q

Symptoms of IM are similar with?

A

Symptoms of early stage of AIDS
- fever
-fatigue
-sore throat
-swollen lymph glands

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11
Q

Cell associated with IM that is oversized, has nuclei and cytoplasm surrounded by RBCs

A

Atypical T-Lymphocytes

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12
Q

Forssman uses __________ that are injected into _________

A

Guinea pig cells, rabbit cells

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13
Q

What are the antibodies formed in Forssman?

A

Anti-guinea pig cells and anti-sheep cells

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14
Q

It is used for any substance that stimulated the formation of sheep hemolysin (Anti-sheep cells)

A

Forssman Antigen

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15
Q

Antibodies produced by unrelated species (Plant, animal, human) which can cross-react with the same antigen

A

Heterophil Antibodies

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16
Q

What are the cells used to differentiate the Three experiments?

A
  1. Sheep cells
  2. Ox/Beef Cells
  3. Horse Cells
  4. Guinea Pig Cells
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17
Q

Heterophil antibodies in IM reacts with what cells?

A

Reacts with sheep, ox, and horse cells and NOT guinea pig cells

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18
Q

Heterophil antibodies in Forssman reacts with what cells?

A

Reacts with guinea pig, horse, sheep cells and NOT in ox/beef cells

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19
Q

Heterophil antibodies in serum sickness reacts with what cells?

A

Reacts with all four cells (Sheep, ox, horse and
Guinea pig ells)

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20
Q

What cells are the most useful for differentiation of the THREE?

A

Guinea pig and Ox Cells

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21
Q

In serum sickness, ________ can be used as control to evaluate and validate the reagent used.

A

Antibodies

22
Q

What is the Principle of Paul Bennet Test?

A

Hemagglutination

23
Q

Presumptive test for the presence for
heterophile antibodies

A

Paul Bennet Test

24
Q

Detects the antibodies of infectious
mononucleosis, Forssman, and serum sickness

A

Paul Bennet Test

25
Q

Paul Bennet test can identify the specific nature of the
heterophil antibody.

True or False

A

False

Cannot identify the specific nature of the
heterophil antibody and Can only tell if heterophil antibodies
are present

26
Q

Paul bennet test is incapable of determining specificity and is only
indicative of the presence or absence of
heterophil

True or False

A

True

27
Q

Reagent Antigen in Paul Bennet Test

A

2% suspension of sheep rbcs

28
Q

Antibody used in Paul Bennet test

A

Heterophil Abs in patient’s serum

29
Q

(+) in Paul bennet test means

A

there is hemmagglutination and presence of heterophil antibodies

30
Q

Principle of Davidson Differential test

A

Absorption hemagglutination

31
Q

What are the Two steps in Davidson Differential Test?

A

A. Absorption
B. Hemagglutination

32
Q

Exposure of test serum to both beef cells and
guinea pig cell which causes absorption of
either one or both of these antibodies

A

Absorption

33
Q

Antigen in Davidson Differential Test

A

guinea pig kidney and beef rbcs

34
Q

Antibodies in Davidson Differential Test

A

heterophil abs in patient’s serum

35
Q

Indicator cells in Davidson Differential Test

A

Sheep RBCs

36
Q

The “Absorbed Agglutinins” (precipitates)
are removed by centrifugation and the
resultant fluid (supernatant) are then tested
with Sheep RBC

A

Hemagglutination

37
Q

If the tube in Davidson is positive for absorption ->
Antibody titer will _________ -> Agglutination
___________

A

decrease, weakens

38
Q

If the tube in Davidson is negative for absorption ->
antibody titer will _________ -> agglutination is
____________

A

increase, strong

39
Q

ABSORPTION PATTERN
Hetero Abs Beef RBCS GPKC
Forssman _______. ________
IM ________. ________
Serum sickness ________ ________

A

ABSORPTION PATTERN
Hetero Abs Beef RBCS GPKC
Forssman No Yes
IM Yes no
Serum Sickness. Yes Yes

40
Q

AGGLUTINATION PATTERN
Hetero Abs. Beef RBCS GPKC
Forssman. _________ ______
IM _________ ______
Serum Sickness _______. _____

A

AGGLUTINATION PATTERN
Hetero Abs. Beef RBCS. GPKC
Forssman ++++ +
IM + ++++
Serum Sickness ++ ++

41
Q

Principle of Monospot

A

Absorption Hemagglutination

42
Q

Antigen in Monospot

A

Guinea pig kidney cells and Beef RBCS

43
Q

Antibody in Monospot

A

Heterophil Abs in patient’s serum

44
Q

Indicator cell in Monospot

A

Horse Cells

45
Q

When Papain is added to sheep cells in Monospot, the
receptors for the Abs are specifically
_____________.

A

Inactivated

46
Q

Used to differentiate a sheep rbc that are
native and those that Papain Treated

A

Rapid Differential Slide Test Using Papain-treated Sheep RBCs

47
Q

Principle of Rapid Differential Slide Test Using Papain-treated Sheep RBCs

A

Hemagglutination

48
Q

Is there an agglutination in normal serum and IM serum when Native Sheep RBC is used?

A

Yes

49
Q

Is there an agglutination in Serum sickness and other heterophil abs when Native Sheep RBC is used?

A

Yes

50
Q

Is there an agglutination in Serum sickness and other heterophil abs when Papain-treated Sheep RBC is used?

A

yes

51
Q

Is there an agglutination in normal serum and IM serum when Papain-treated Sheep RBC is used?

A

None or weak agglutination

Infectious Mononucleosis (1 decks)

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