ILAs Flashcards
Management of juvenile infant arthritis?
-NSAIDs, such as ibuprofen
-Steroids, either oral, intramuscular or intra-artricular in oligoarthritis
-DMARDs- methotrexate, sulfasalazine and leflunomide
-Biologics -TNF inhibitors etanercept, infliximab and adalimumab
What is still disease
-a subtype of Juvenile idiopathic arthritis
-which is systemic and can affect joints and organs
Signs of stills disease (systemic arthritis) (8)
-Subtle salmon-pink rash
-High swinging fevers
-Enlarged lymph nodes
-Weight loss
-Joint inflammation and pain
-Splenomegaly
-Muscle pain
-Pleuritis and pericarditis
Complication of Systemic JIA?
-macrophage activation syndrome
What is macrophage activation syndrome?
-severe activation of the immune system and inflammatory response
Investigation that will suggest Macrophage activation syndrome?
Low ESR
Key NON INFECTIVE differentials of a high grade fever for 5+ days? (4)
-Kawasaki disease
-stills’s disease
-rheumatic fever
-leukemia
5 Subtypes of JIA?
-Systemic JIA
-Polyarticular JIA
-Oligoarticular JIA
-Enthesitis related arthritis
-Juvenile psoriatic arthritis
Macrophage activation syndrome presentation
-stills disease presentation
PLUS
-aneamia
-DIC
-thrombocytopenia
-non blanching rash
What is polyarticular arthritis?
-Idiopathic inflammatory arthritis in 5 joints or more
-tends tot be symmetrical
What is oligoarticular JIA?
- idiopathic inflammatory arthritis, involving 4 joints or less
-tends to affect larger joints like hips and knees
What presentation is commonly associated with Oligoarticular JIA?
Anterior uveitis
Which group is e the sites related arthritis more common in
Males over 6 years
- equivalent to seronegative spondyloarthropathies such as Ankylosing spondylitis, psoriatic arthritis and reactive arthritis
What is an enthesis?
Point at which the tendon of a muscle inserts into a bone
What is Enthesitis-Related Arthritis?
Inflammation of the insertion point of a tendon to bone
