IL match ups Flashcards
1
Q
IL-1
A
Secreted by MP
- aka osteoclast-activating factor
- causes fever, acute inflammation
- activates endothelium to express adhesion molecules
- induces chemokine secretion to recruit WBCs
"Hot T-bone stEAK" IL-1: fever IL-2: stimulates T cells IL-3: stimulates bone marrow IL-4: stimulates IgE production IL-5: stimulates IgA production IL-6: stimulates aKute-phase protein production
2
Q
IL-6
A
- secreted by MP
- Causes fever and stimulates production of acute-phase proteins
"Hot T-bone stEAK" IL-1: fever IL-2: stimulates T cells IL-3: stimulates bone marrow IL-4: stimulates IgE production IL-5: stimulates IgA production IL-6: stimulates aKute-phase protein production
3
Q
IL-8
A
Secreted by MP
-major chemotactic for neutrophils
“Clean up on aisle 8”: Neutrophils recruited by IL-8 to clear infections
4
Q
IL-12
A
Secreted by MP
- Induces differentiation of T cells into Th1 cells
- Activates NK cells
5
Q
TNF-alpha
A
Mediates septic shock
- Activates endothelium
- Causes WBC recruitment, vascular leak
- Stimulates Th1 cells
6
Q
IL-2
A
Secreted by all T cells
-Stimulates growth of helper, cytotoxic and regulatory T cells, and NK cells
"Hot T-bone stEAK" IL-1: fever IL-2: stimulates T cells IL-3: stimulates bone marrow IL-4: stimulates IgE production IL-5: stimulates IgA production IL-6: stimulates aKute-phase protein production
7
Q
IL-3
A
Secreted by all T cells
-Supports growth and differentiation of bone marrow stem cells (functions like GM-CSF)
"Hot T-bone stEAK" IL-1: fever IL-2: stimulates T cells IL-3: stimulates bone marrow IL-4: stimulates IgE production IL-5: stimulates IgA production IL-6: stimulates aKute-phase protein production
8
Q
IFN-gamma
A
Secreted by Th1 cells
- Secreted by NK cells and T cells in response to IL-12 from the macrophages
- Stimulates MP to kill phagocytosis pathogens
- Inhibits differentiation of Th2 cells
- Activates NK cells to kill virus-infected cells
- Increases MHC expression and Ag presentation by all cells
9
Q
IL-4
A
Secreted by Th2 cells
- Induces differentiation of T cells into Th2 cells
- Promotes growth of B cells
- Enhances class switching to IgE and IgG
"Hot T-bone stEAK" IL-1: fever IL-2: stimulates T cells IL-3: stimulates bone marrow IL-4: stimulates IgE production IL-5: stimulates IgA production IL-6: stimulates aKute-phase protein production
10
Q
IL-5
A
Secreted by Th2 cells
- Enhances class switching to IgA
- Stimulates growth and differentiation of eosinophils
"Hot T-bone stEAK" IL-1: fever IL-2: stimulates T cells IL-3: stimulates bone marrow IL-4: stimulates IgE production IL-5: stimulates IgA production IL-6: stimulates aKute-phase protein production
11
Q
IL-10
A
Secreted by Th2 cells
- Attenuates inflammatory response
- Decreases expression of MHC Class II and Th1 cytokines
- Inhibits activated MP and dendritic cells
- Also secreted by T regulatory cells
“TGF-beta and IL-10 both attenuate the immune response”
