III - Tissue Repair, Healing and Fibrosis-1

Question 2

Cells of these tissues are continuously being lost and replaced by maturation from stem cells and by proliferation of mature cells. Can readily regenerate after injury as long as the pool of stem cells is preserved.

Answer 2

Labile tissues(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 3

Cells of theses tissues are quiescent and have only minimal replicative activity in their normal state. Capable of proliferating in response to injury or loss of tissue mass.

Answer 3

Stable tissues(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 4

Cells of these tissues are considered to be terminally differentiated and nonproliferatvie in postnatal life.

Answer 4

Permanent tissues(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.62

Question 5

Labile, stable or permanent tissues:Bone marrow

Answer 5

Labile(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 6

Labile, stable or permanent tissues:Vaginal epithelium

Answer 6

Labile(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 7

Labile, stable or permanent tissues:Salivary glands

Answer 7

Labile(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 8

Labile, stable or permanent tissues:Liver parenchyma

Answer 8

Stable(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 9

Labile, stable or permanent tissues:Endothelium

Answer 9

Stable(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 10

Labile, stable or permanent tissues:Smooth muscle cells

Answer 10

Stable(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 11

Labile, stable or permanent tissues:Neurons

Answer 11

Permanent(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.62

Question 12

Labile, stable or permanent tissues:Cardiac muscle

Answer 12

Permanent(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.62

Question 13

Type of collagen found in basement membrane

Answer 13

Type IV collagen(TOPNOTCH)

Question 14

Type of collagen found in basement membrane

Answer 14

Type IV collagen(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.67

Question 15

This is the most abundant glycoprotein in basement membrane.

Answer 15

Laminin(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.68

Question 16

The pink, soft, granular tissue seen beneath the scab of a skin wound.

Answer 16

Granulation tissue(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.70

Question 17

Maturation and reorganization of fibrous tissue

Answer 17

Remodeling(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.70

Question 18

Healing of a clean, uninfected surgical incision approximated by surgical sutures

Answer 18

Healing by first intention / Primary Union(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.74

Question 19

Type of healing wherein tissue is allowed to heal by itself before suturing. Used in large wounds, in the presence of abscess, or ulceration.

Answer 19

Healing by secondary intention / secondary union(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.76

Question 20

Wound strength reaches 70 - 80 % of normal in ______ months.

Answer 20

3 months(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.77

Question 21

Single most important cause of delay in wound healing.

Answer 21

Infection(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.77

Question 22

True or false: Complete restoration can occur only in tissues composed of stable and labile cells.

Answer 22

True(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.77

Question 23

Refers to the restoration of tissue architecture and function after an injury.

Answer 23

Repair (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.77

Question 24

True or false:Injury to tissues composed of permanent cells does not result to scarring.

Answer 24

False. Injury to tissues composed of permanent cells, inevitably results to scarring.(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.77

Question 25

Process of replacing damaged components of a tissue, returning to a normal state.

Answer 25

Regeneration (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.77

Question 26

Migration and proliferation of fibroblasts with deposition of ECM.

Answer 26

Scar formation(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.72

Question 27

Maturation and reorganization of fibrous tissue

Answer 27

Remodeling(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.73

Question 28

The pink, soft, granular tissue seen beneath the scab of a skin wound.

Answer 28

Granulation tissue(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.73

Question 29

Arrange the steps in cutaneous wound healing:A. Formation of granulation tissueB. ECM remodelingC. Inflammation

Answer 29

C, A, B(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.72

Question 30

It consists of a series of steps at which the cell checks for the accuracy of replication and mitosis and instructs itself to proceed to the next step.

Answer 30

Cell cycle(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 31

In the cell cycle, this is called the presynthetic growth phase.

Answer 31

G1(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 32

In the cell cycle, this is also called the premitotic growth phase.

Answer 32

G2(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 33

These steps in the cell cycle prevents DNA replication or mitosis of damaged cells and either transiently stop the cell cycle to allow repair, or eliminate irreversibly damaged cells by apoptosis.

Answer 33

Checkpoint control(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 34

These enzymes promote DNA replication and various aspects of mitosis. They are required for cell cycle progression. Forms complexes with cyclin.

Answer 34

Cyclin-deoendent kinases (CDK)(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

Question 35

This cytokine is released from activated macrophages, and is mitogenic for keratinocytes and fibroblasts. It also stimulates keratinocyte migration and granulation tissue formation.

Answer 35

Epidermal Growth Factor (EGF)(TOPNOTCH)

Question 36

This cytokine increases vascular permeability and is mitogenic for endothelial cells.

Answer 36

Vascular Endothelial Growth Factor (VEGF)(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.71

Question 37

Pattern of extracellular signaling wherein the target cell is itself.

Answer 37

Autocrine(TOPNOTCH)

Question 38

Pattern of extracellular signaling wherein the target cell is adjacent to the secretory cell.

Answer 38

Paracrine(TOPNOTCH)

Question 39

Pattern of extracellular signaling wherein the target cell is distant to the secretory cell.

Answer 39

Endocrine(TOPNOTCH)

Question 40

Synthesized by mesenchymal cells, present in the spaces between cells in connective tissue, between epithelium and supportive vascular and smooth muscle structures.

Answer 40

Interstitial Matrix(TOPNOTCH)

Question 41

Component of ECM which confers tensile strength and recoil.

Answer 41

Fibrous proteins s.a. Collagen and elastin(TOPNOTCH)

Question 42

Component of ECM that permits resilience and lubrication.

Answer 42

Proteoglycans, hyaluronan(TOPNOTCH)

Question 43

Component of ECM that connect the elements to one another and to the cells.

Answer 43

Adhesive glycoproteins(TOPNOTCH)