III - Skeletal Muscle Disease Flashcards
What is the clinical use of serum chemistry in the diagnosis and treatment of equine muscle disease?
Look at CK and AST.
CK
- released into circulation with myofiber damage
- rapid peak and decay
- normal <300 IU/L
List causes of focal muscle atrophy.
Denervation
Osteoarthritis
Trauma
Neoplasia
Immune mediated
Up to 2/3 of muscle mass may be lost within 2-3 weeks of peripheral denervation. Easier to assess than generalized unless it’s bilateral.
List causes of muscle hypertrophy.
Training
Compensation for fiber loss elsewhere
Muscle disorders
Name the anatomical sites commonly used to obtain a muscle biopsy.
DFDX for a horse with a mild (<1000 IU/L) increase in serum CK activity.
What are the most common clinical signs of rhabdomyolysis?
How would you diagnose rhabdomyolysis?
How do you treat rhabdomyolysis?
Explain to an owner the precautions you will take to prevent anesthesia-related rhabdomyolysis.
Explain the pathophysiologic basis underlying the most common acid-base disturbance in exhausted horses.
List genetic causes of rhabdomyolysis in different horse breeds.
Compare genetic causes of rhabdomyolysis in terms of inheritance.
Compare genetic causes of rhabdomyolysis in terms of pathophysiology.
Compare genetic causes of rhabdomyolysis in terms of clinical signs.
Compare genetic causes of rhabdomyolysis in terms of diagnosis.
Compare genetic causes of rhabdomyolysis in terms of treatment.
Compare genetic causes of rhabdomyolysis in terms of prevention.
What is known about shivers?
What breeds does shivers affect?
Explain the mode of inheritance for HYPP in Quarter horses.
Name the specific stallion associated with HYPP.
Impressive
Explain the cause of white muscle disease.
Describe the clinical signs of white muscle disease.
Describe how to diagnose white muscle disease.
Describe how to treat white muscle disease.
What is the classic presentation and case history of a horse with clostridia myonecrosis?
Provide a diagnostic plan for a horse with clostridial myonecrosis.
Provide a treatment plan for a horse with clostridial myonecrosis.
List causes of generalized muscle atrophy.
Equine Motor Neuron disease
Vitamin E deficiency
Immune mediated myosin is
PSSM1 homozygotes
Harder to identify subtle changes without routine monitoring of muscle mass.
