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Pharm > IDSA Guidlines - USC Arcadia > Flashcards

IDSA Guidlines - USC Arcadia Flashcards

1
Q

Initial treatment

CAP

OUTPT; no comorbidities OR RF for pseudomonas

PO

A

B-lactam
+
Macrolide or doxy

Macrolide = azithromycin

B-lactam = amoxicillin

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2
Q

Initial treatment

CAP

OUTPT; with comorbidities

PO

A

Comination therapy

a)** Augementin** OR Ceph
+
Macrolide

b) **Resp FQ **monotherapy

Resp FQ = lexofloxacin, moxifloxacin

Cephs = cepfodoxime, cefuroxime

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3
Q

Regimen

CAP

Non-ICU

A

**Ceftriaxone ** 1-2g q24h
+
azithromycin 500mg QD OR doxycycline 100mg BID

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4
Q

Regimen

CAP
Non-ICU (with Pseudomonas risk)

A

Zosyn 4.5g q6h
+
azithromycin 500mg QD
+
tobramycin 5-7mg/kg QD

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5
Q

Regimen

CAP
ICU

A

ceftriaxone 1-2 q24h OR Zosyn 4.5 q6h
+
azithromycin 500mg QD
+/-
vancomycin 15mg/kg q8-12h (if MRSA risk)

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6
Q

Empiric therapy

HAP
NO high risk of mortality; NO RF for MRSA

A

Zosyn 4.5g q6h
(or cefepime, FQ, carbapenem)

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7
Q

Empiric therapy

HAP
NO high risk of mortality; INC RF for MRSA

A

Zosyn 4.5g q6h
(or cefepime, FQ, carbapenem)
+
vancomycin 15mg/kg q8-12h

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8
Q

Empiric therapy

HAP
HIGH risk mortality; INC RF (abx w/in prior 90 days)

A

Zosyn 4.5g q6h
(or cefepime, FQ, carbapenem)
+
tobramycin 5-7mg/kg
(or another AG)
+
vancomycin 15mg/kg q8-12h

Allergy: aztreonam (instead of Zosyn)

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9
Q

Empiric therapy

VAP

A

Gram (+) with MRSA activ
(vancomycin, linezolide)
+
Gram (-) with Pseudomonas activ (B-lactam)
(Zosyn, cephs - cefepime, ceftazidine, carbapenems)
+
Double Pseudomonas activ (non-B-lactam)
(FQ - cipro, levo, AG - amikacin, gentamicin, tobramycin, polymyxins)

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10
Q

Suggested regimen

HAP/VAP

A

Zosyn 4.5g q6h
+
tobramycin 5-7mg/kg QD
+
vancomycin 15mg/kg q8-12h

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11
Q

Common pathogens

UTI
(acute uncomplicated cystitis, pyelonephritis)

A
  1. E. coli
  2. Proteus mirabilis
  3. Klebs pneumoniae
  4. Staph saprophyticus
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12
Q

Treatment options

UTI
Acute uncomplicated cysitis

A
  1. Macrobid x7d
  2. Bactrim x3d
  3. Fosfomycin x1 dose
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13
Q

Treatment options

UTI
Acute pyelonephritis

A
  1. Ciprofloxacin (QD or BID) x7d OR levofloxacin QD x5d
  2. Bactrim DS BID x14d
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14
Q

Treatment options

UTI
Acute pyelonephritis req. hospitlization

A

IV ABX
1. FQ
2. carbapenems
2. AG
3. ES cephs, PCNs

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15
Q

Treatment options

UTI
Asymtomatic Bacteriuria in pregnant women

>= 10^5 CFU/ml, NO sx

A
  1. Macrobid
  2. B-lactam (ampicillin, cephalexin)
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16
Q

Treatment options

UTI
Asymtomatic Bacteriuria in endoscopic urologic proced

>= 10^5 CFU/ml, NO sx

A
  1. urine culture
  2. targeted abx
  3. abx should be initaited 30-60min before procedure
17
Q

Common pathogens

Cellulitis

SSTI

A
  1. Group A strep (Strep pyogenes)
  2. S. aureus
  3. S. pneumoniae

Duration tx: 5-7d

18
Q

Treatment options

Cellulitis
SEVERE

Clostridial sp.

A

Penicillin
+
Clindamycin

19
Q

Treatment options

Cellulitis
SEVERE

Strep pyogenes

A

Pencillin
+
Clindamycin

21
Q

Treatment options

Cellulitis
SEVERE

Aeromonas hydrophila

A

Doxycycline
+
Ciprofloxacin

21
Q

Treatment options

Cellulitis
SEVERE

Vibrio vulmificus

A

Doxycycline
+
Ceftazidime

22
Q

Treatment options

Cellulitis
SEVERE

Vibrio vulmificus

A

Doxycycline
+
Ceftazidime

23
Q

Treatment options

Cellulitis
SEVERE

Polymicrobial

A

Vancomycin
+
Zosyn

24
Q

Treatment options

Cellulitis
MODERATE

Systemic sx of infection

A

IV ABX
Cefazolin
(or PCN, ceftraixone, clindaymycin)

25
Q

Treatment options

Cellulitis
MILD

No systemic sx of infection

A

PO ABX
1. PCN VK
2. cephs
3. dicloxacillin
4. clindamycin

26
Q

Empiric treatment

Purluent SSTI
SEVERE

furnucle, carbuncle, abscess

A

IV ABX
1. vancomycin
2. daptomycin
3. linezolid
4. televancin
5. ceftaroline

Empiric tx - cover MRSA

27
Q

Defined tx

Purluent SSTI
SEVERE

furnucle, carbuncle, abscess

A

IV ABX
MRSA - see empiric tx
MSSA
1. naficillin/oxacillin (DOC for MSSA)
2. cefazolin
3. clindamycin

Defined tx

28
Q

Empiric treatment

Purluent SSTI
MODERATE

furnucle, carbuncle, abscess

A

PO ABX
1. Bactrim
2. Doxycycline

Empiric tx - cover MRSA

29
Q

Defined tx

Purluent SSTI
MODERATE

furnucle, carbuncle, abscess

A

MRSA - see empiric tx
MSSA
1. dicloxacillin (DOC for MSSA)
2. cephalexin

30
Q

Suggested treatment

Severe SSTI

A

Zosyn
+
vancomycin

Covers MRSA, E. coli, B frag

31
Q

Suggested treatment

Mild/moderate SSTI

A

Cefazolin

Pharm (7 decks)

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