IDIT Flashcards
What infects T cells with a T cell defect
Viruses and intracellular shit
What infects B cells with a B cell difficiency
Bacteria
X linked lymphopenic hypogammaglobulinemia
y-chain of IL-2 receptor
Affects everything
Rag 1 Rag 2
autosomal T cell and B cell SCID
a- chain of IL2
Defective T cell autosomal SCID
ADA difficiency
Multiple cells affected, autosomal
Wiskott aldrich syndrome
Gets Worse with age, B and T cell Actin problem
DiGeorge syndrome
Athymic
Ataxia telangiectasio
T cell defect Chromosome 14 problem in a/delta locus and IgH chains
Tap
Lack of MHC 1
Bare lymphocyte syndrome
Lack of MHC 2
X-linked hypogammaglobulinemia
B cell defect with no light chain, All Abs low
X-linked hyper igM
CD40L on T-cell defect, unable to class switch
Selective dificiencies
Mostly with IgA, is a defect outside Ig genes
Chronic granulomatous disease
Defective oxidative burst in phagocites because a lack of NADPH oxidase activity, confirm with NBT dye, have excessive inflamation