Idiopathic Pulmonary Fibrosis Flashcards
1
Q
What treatments are available for idiopathic pulmonary fibrosis?
A
Nintedanib - tyrosine protein kinase inhibitor
Pirfenidone - mechanism unknown, has anti-fibrotic and anti-inflammatory properties
2
Q
What are the effects of pirfenidone and nintedanib?
A
- slows rate of FVC decline
- no change in mortality
- no demonstratable change in QoL
3
Q
What did the PANTHER-IPF trial show?
A
Randomised double-blinded placebo controlled trial of prednisolone/azathioprine/NAC vs N-acetylcysteine vs placebo that was terminated early due to increased rate of deaths and hospitalisation in combination therapy group
