Identification

Question 1

Answer 1

Hemophagocytosis

Question 2

Answer 2

Dutcher Body- PAS positive stain appears intranuclear, actually cytoplasmic and invaginates nucleus in Waldenstroms and Myeloma

Question 3

Answer 3

Bone Marrow Fibrosis

Question 4

Answer 4

Pappenheimer Body- siderotic granule made of iron, often in clusters. Assoc. with splenectomy, hemolytic anemia, sideroblastic anemia, megaloblastic anemia, and hemoglobinopathies

Question 5

Answer 5

Mott Cell- seen in Myeloma

Question 6

Answer 6

Dohle Body

Question 7

Answer 7

Dohle Body​

Question 8

Answer 8

Mott Cell (Grape Cell) seen in Myeloma

Question 9

Answer 9

Hemophagocytosis

Question 10

Answer 10

Flame Cell- Eosinophilc appearing plasma cell in Multiple Myeloma often in IgA secreting myeloma

Question 11

Answer 11

Large Granular Lymphocyte- larger than resting lymphocyte w/ more cytoplasm and azurophilic granules. Either CD8 T cells or NK cells (CD56) and seen in viral infections and large granular lymphocytic leukemia

Question 12

Answer 12

Chediak-Higashi Syndrome. AR disorder of abnormal lysosome trafficking leading to inclusions in leukocytes. Recurrent infections, partial albinism, and peripheral neuropathy​

Question 13

Answer 13

Idiopathic Hypereosinophilic Syndrome with BM showing expansion of mature eosinophils and eosinophilic myelocytes

Question 14

Answer 14

Flame Cell. Plasma cells with distinctive pinkish hue thought to be precipitated immunoglobulin most likely IgA. Seen in Myeloma.

Question 15

Answer 15

Microangiopathic Hemolytic Anemia. Note the schistocytes

Question 16

Answer 16

Hemophagocytic Lymphohistiocytosis- the histiocyte nuclei are the more spongy ones. They are engulfing lymphoma cells.

Question 17

Answer 17

Pseudothrombocytopenia- platelet clumping due to interaction of EDTA with Gp IIb/IIIa

Question 18

Answer 18

Follicular Lymphoma- note the paratrabecular lymphoid aggregates

Question 19

Answer 19

Smudge Cells of CLL

Question 20

Answer 20

Cold Agglutinin Disease- often IgM or anti-C3 ​

Recall: most hemolysis takes place in liver whereas warm AIHA takes place in spleen. Can be assoc. with Mycoplasma

Question 21

Answer 21

Plasma Cells, likely Myeloma containing Snapper-Schneid granules​

Question 22

Answer 22

Dutcher Body- PAS + staining intranuclear inclusion

Question 23

Answer 23

Pelger Huet Anomaly- bilobed neutrophil. If present in only some neuts it is pseudo-Pelger-Huet anomaly and indicative of MDS (dysmyelopoiesis)