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ID Flashcards

1
Q

Side effects of quinolones

A

Achilles tendinitis
QT prolongation
AAA

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2
Q

ESCHAPPM Mechanism and organisms

A 
Inducible beta lactamase, AmpC gene
Enterobacter spp (Also includes Klebsiella aerogenes)
Serratia spp
Citrobacter freundii
Hafnia
Aeromonas/Actinobacter
Proteus vulgaris
Providencia
Morganella morganii
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3
Q

Antifungal
Echinocandins
MOA, examples

A

Inhibit 1,3 beta D glucan synthase

e.g caspofungin, micafungin, anidulafungin

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4
Q

Antifungals
Azoles
MOA, examples

A

Impairs synthesis of ergosterol in cell membranes causing breakdown

eg
posaconazole, voriconazole

SE
hepatotoxicity, thrombocytopaenia, peripheral neuropathy

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5
Q

Antifungals
amphotericin B
MOA

A

Binds to ergosterol in fungal cell membranes causing cell death by altering their permeability and allowing leakage of intracellular components

SE
infusion reaction, nephrotoxicity, deranged LFTs

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6
Q

PJP prophylaxis +

treatment

A 
prophylaxis: bactrim first line
otherwise dapsone (check G6PD)

treatment: 1. bactrim
2. primiquine + clindamycin

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7
Q

CSF suspicion of ventriculitis if no growth on culture

A

WCC:RBC
1:500

Suspect if more

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8
Q

Tx of ventriculitis (nosocomial)

A

Vancomycin + Ceftazidime/Cefepime

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9
Q

Syphilis investigations

A

Serology

  • treponemal: FTA, TPPA, syphilis ab
  • non-tremonemal: RPR, VDRL

Tertiary syphilis - CSF serology (NOT PCR)

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10
Q

Antibiotics MOA
Beta lactams?

Bonus q: pharmacodynamic activity?

A

Inhibits synthesis of peptidoglycan wall
Includes: penicillins, cephalosporins, carbapenems

Bonus q: time above MIC (time-dependent)

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11
Q

Antibiotics MOA

Glycopeptides?

A

Inihibits synthesis of peptidoglycan wall by binding to amino acids on wall, preventing addition of new units (acyl-D-alanyl-D-alanine)

e.g. vancomycin, teicoplanin

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12
Q

Antibiotics MOA
Aminoglycosides?

Bonus q: pharmacodynamic activity?

A

Binds to 30S subunit of ribosomes.

e.g. gentamicin, amikacin

Bonus q: peak plasma concentration

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13
Q

Antibiotics MOA

Macrolides?

A

Binds to 50S subunit of ribosomes

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14
Q

Antibiotics MOA

Tetracyclines

A

Binds to 30S subunit

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15
Q

Antibiotics MOA

Fluoroquinolones?

A

Interfere with DNA replication by inhibiting ligase activity (type II topoisomerase, DNA gyrase and tpopisomerase IV)

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16
Q

Antibiotics MOA

Trimethoprim

A

Inhibits folic acid synthesis

BPT (5 decks)

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