ICU Prophylaxis Flashcards

1
Q

How long do you hold aspirin and NSAIDs before surgery?

A

Discontinue at least 10-14 days prior to surgery

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2
Q

How long do you hold warfarin before surgery?

A

Discontinue at least 4-5. days prior to surgery (depends on type of surgery)

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3
Q

How long do you hold dabigatran, rivaroxaban, and apixaban?

A

Discontinue 1-2 days prior to surgery

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4
Q

What is the pathophysiology of DVT and PE?

A
  • Endothelial injury
  • Hypercoagulable state
  • Circulatory stasis
    Virchow’s triad
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5
Q

What are some risk factors of venous stasis DVT and PE?

A
  • Age > 60 years
  • Obesity > 30 years
  • Prolonged immobility
  • Paralysis
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6
Q

What are some risk factors of injury for DVT and PE?

A
  • Surgery
  • Trauma
    Especially involving spine, pelvis, and knees
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7
Q

What are some risk factors of hypercoaguable state for DVT and PE?

A
  • Protein C or S def
  • Prior VTE
  • Malignancy
  • Antiphospholipid antibodies (APLA)
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8
Q

What is considered a high risk patient for DVT/PE?

A
  • Trauma patient or non-major surgery, aged > 60 year with additional risk factors
  • Trauma patient or major surgery, aged > 40 year with additional risk factors
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9
Q

What is the prevention treatment plan for high risk patients for DVT/PE?

A
  • LDUH (heparin 5000 mg BID or TID) + IPC
    OR
  • LMWH (enoxaparin [Lovenox] 30 mg BID or 40 mg/day) + IPC
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10
Q

What is a very high risk patient for DVT/PE?

A
  • Total hip arthroplasy (THA)
  • Total knee arthroplasty (TKA)
  • Hip fracture surgery (HFS)
  • Spinal cord injury
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11
Q

What is the prevention treatment for high risk patients for DVT/PE?

A
  • LMWH + IPC
  • LDUH + IPC
  • Apixaban, dabigatran, fondaparinux
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12
Q

What are the 3 independent risk factors of stress related mucosal damage (SMRD)?

A
  • Respiratory failure requiring MV (mechanical ventilation)
  • Coagulopathy (Platelet < 50,000; INR > 1.5)
  • Traumatic brain/spinal cord injury
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13
Q

What are some dependent risk factors of SMRD?

A
  • Acute renal failure (Scr > 2.8 or CrCl < 30)
  • Burns, hypotension, trauma, GI bleed < 12 weeks)
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14
Q

What are some surgical site infection patient-related risk factors?

A
  • Advanced/young age
  • Active remote site infection
  • Diabetes
  • Obesity
  • Nicotine
  • Immunocompromised
  • Poor nutrition
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15
Q

What are some typical SSI antibiotics?

A
  • Cefazolin
  • Cefurozime
  • Ceftriaxone
  • Clindamycin
  • **Vancomycin **
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16
Q

When do you give SSI antibiotics?

A

30-60 min before incision

17
Q

How long should you be on SSI antibiotics?

A

Typically 24 hours post operation