ICU Prophylaxis Flashcards
How long do you hold aspirin and NSAIDs before surgery?
Discontinue at least 10-14 days prior to surgery
How long do you hold warfarin before surgery?
Discontinue at least 4-5. days prior to surgery (depends on type of surgery)
How long do you hold dabigatran, rivaroxaban, and apixaban?
Discontinue 1-2 days prior to surgery
What is the pathophysiology of DVT and PE?
- Endothelial injury
- Hypercoagulable state
- Circulatory stasis
Virchow’s triad
What are some risk factors of venous stasis DVT and PE?
- Age > 60 years
- Obesity > 30 years
- Prolonged immobility
- Paralysis
What are some risk factors of injury for DVT and PE?
- Surgery
- Trauma
Especially involving spine, pelvis, and knees
What are some risk factors of hypercoaguable state for DVT and PE?
- Protein C or S def
- Prior VTE
- Malignancy
- Antiphospholipid antibodies (APLA)
What is considered a high risk patient for DVT/PE?
- Trauma patient or non-major surgery, aged > 60 year with additional risk factors
- Trauma patient or major surgery, aged > 40 year with additional risk factors
What is the prevention treatment plan for high risk patients for DVT/PE?
- LDUH (heparin 5000 mg BID or TID) + IPC
OR - LMWH (enoxaparin [Lovenox] 30 mg BID or 40 mg/day) + IPC
What is a very high risk patient for DVT/PE?
- Total hip arthroplasy (THA)
- Total knee arthroplasty (TKA)
- Hip fracture surgery (HFS)
- Spinal cord injury
What is the prevention treatment for high risk patients for DVT/PE?
- LMWH + IPC
- LDUH + IPC
- Apixaban, dabigatran, fondaparinux
What are the 3 independent risk factors of stress related mucosal damage (SMRD)?
- Respiratory failure requiring MV (mechanical ventilation)
- Coagulopathy (Platelet < 50,000; INR > 1.5)
- Traumatic brain/spinal cord injury
What are some dependent risk factors of SMRD?
- Acute renal failure (Scr > 2.8 or CrCl < 30)
- Burns, hypotension, trauma, GI bleed < 12 weeks)
What are some surgical site infection patient-related risk factors?
- Advanced/young age
- Active remote site infection
- Diabetes
- Obesity
- Nicotine
- Immunocompromised
- Poor nutrition
What are some typical SSI antibiotics?
- Cefazolin
- Cefurozime
- Ceftriaxone
- Clindamycin
- **Vancomycin **