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💊🧬🔬 > Icpp > Flashcards

Icpp Flashcards

1
Q

2 psychological effects of kinase linked receptors

A
  • phosphorylase proteins involved in signalling cascades

- long term effect = stimulate growth / differentiation

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2
Q

Why is a helix most common 2* structure found in membrane spanning region?

A

A helix resides have hydrophobic side chains that interact with fatty acyl groups of membrane phospholipids

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3
Q

Drug target sites?

A

Receptors
Ion channel
Transporters
Enzymes

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4
Q

KING

Target sites further categorised?

A

Kinase linked receptors
Ion channels - ligand gated
Nuclear receptors / intracellular
GPCR

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5
Q

Endocrine signalling mol. Unit range?

A

10^-6M to 10^-12

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6
Q

Why is fluid mosaic model both fluid like and static?

A

Fluid = from hydrocarbon chains combined with cholesterol - they’re free to move laterally cause they rnt. Covalently linked

Static= from large conglomerates that r bound to each other (eg. Connexions and lipid rafts)

Fluid mosaic = membrane can be both fluid and static

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7
Q

Membrane bilayer form ___ in water. They’re bonded by ____ bonds called ______ between _____ and____ bonds between

A 
Spontaneously 
Non covalent 
Van dear walls 
Hydrophobic 
Hydrogen bonds
Hydrophilic heads
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8
Q

Integral membrane and lipid anchored membrane r similar in…

A

The fact they r held to membrane by hydrophobic interactions

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9
Q

Greater fluidity in membrane is achieved by

A

Unsaturated bonds

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10
Q

Difference between multi pass membrane proteins and a multi subunit membrane protein

A

Multi pass = single poly p. Chain that penetrates membrane twice

Multi subunit = more than 1 poly p. Where each is called a subunit

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11
Q

Band 3

A

Integral
Glycoprotein + hydrophilic
Prevents flip flop

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12
Q

Ankyrin

A

Peripheral
Adapter protein
Links spectrin to band 3
Restricts lateral mobility

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13
Q

Spectrin

A

Peripheral
Long rod like protein / forms heterotetremer
Contributes to shape and flexibility of erythrocytes

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14
Q

Glycophorin A

A

Integral
Glycoprotein, hydrophilic
Prevents flip flop rotation

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15
Q

Band 4.1

A

Peripheral
Protein
Links spectrin to glycophorin A ; restricts lateral mobility

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16
Q

When ACh binds to nAChR which ions go through

A

K
Cl
Na

17
Q

Why is resting potential not the same as eqm pot for K

A

Membrane is permeable to other ions eg. Na and Cl

18
Q

Which ion channel contributes to resting pot.

A

K channel

19
Q

How does Na k atpase contribute to membrane pot.

A

Forms the Na and k conc grads needed

20
Q

When nerve becomes permeable to Na what’s its membrane pot and name of its state

A

+55mV

Depolarisation

21
Q

What type of gating is used for signalling in neuromuscular junction

A

Ligand gated

22
Q

Range of resting pot. For nerve cells

A

-50mV to -75mV

23
Q

What channels dominate membrane pot.

A

K plus channels

24
Q

2 things clinically relevant about ap arriving at neuromuscular junction

A
  • disease processes can alter sequence (ca reg. steps) eg. Myasthenia Gravis
  • drugs can block the process. Eg succinylcholine
25
Q

Effect of demyelination

A

Reduced conduction velocity

26
Q

Physiological effects at neurone level if given a drug blocking Na channels

A

??? No action potential formed / no depolarisation

27
Q

SNS receptors and G proteins

A

Alpha 1 = Gq
Alpha 2 = Gi
B1 = Gs

28
Q

PNS receptors and G proteins

A 
B2 = Gs
M1 = Gq
M2 = Gi
29
Q

What r the differences between sns and pns arise from

A

Pns nuclei r found in brain stem and sacral region of spinal cord

Sns nuclei r found in thoracolumbar region of the spinal cord

30
Q

Side effects from muscarinic antagonist drugs

A

Dry mouth / constipation / tachycardia / urinary retention / blurred vision

31
Q

Symptoms from pheochromocytoma

A

Headaches , palpitations, sweating

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