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ICM Exam 2 Rheumatology (MC) > ICM - Rheum 3 > Flashcards

ICM - Rheum 3 Flashcards

1
Q

most common drugs that cause SLE

A

procainamide, hydralazine

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2
Q

possible environmental factors that can trigger SLE

A

molecular mimicry, drugs, hair dye, tobacco smoke, UV light

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3
Q

possibly occurs in SLE due to Ab to cell membrane

A

hemolytic anemia, thrombocytopenia, leukopenia

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4
Q

these are damaged in SLE due to immune complex deposition

A

blood vessels and kidneys

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5
Q

Ab to this in SLE will cause prolonged PTT, venous/arterial thrombosis, fetal distress, livedo reticularis, and thrombocytopenia

A

phospholipid

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6
Q

this occurs from SLE Ab to brain constituents

A

lupus cerebritis

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7
Q

most common cause of death in lupus patient

A

infection

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8
Q

systemic manifestation of SLE

A

fever, weight loss, morning stiffness

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9
Q

skin manifestations of SLE

A

sun sensitive/butterfly rash, maculopapular rash, vasculitis, alopecia, oral ulcers, discoid, subacute cutaneous

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10
Q

skin condition in 19% SLE….sharply defined papule and plaques (raised border) –> central area become atrophic/central clearing (*scars*)

A

discoid lupus

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11
Q

hardening of skin by abnormalities of microvasculature and large vessels and fibrotic changes in muscles, joints, viscera

A

scerloderma

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12
Q

potent vasoconstrictors that are important in pathogenesis of scleroderma

A

endothelins, NO, EDCF

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13
Q

what are targeted in scleroderma?

A

endothelial cells (vascular endothelium)

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14
Q

early phase of scerloderma

A

edematous

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15
Q

classic phase of scleroderma

A

indurative/sclerotic

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16
Q

pulmonary manifestations of scleroderma

A

interstitial fibrosis, dyspnea, pulmonary HTN

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17
Q

GI manifestations of scleroderma

A

esophageal dysmotility, malabsorption (duodenum and jejunum), colonic wide sacculations, biliary cirrhosis

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18
Q

possible cardiac manifestation of scleroderma….secondary R heart failure due to pulmonary HTN

A

cor pulmonale

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19
Q

cardiac manifestations of scleroderma

A

pericardial effusion and cor pulmonale

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20
Q

renal manifestations of scleroderma

A

progressive arterial lesions (intimal proliferation, medial thinning, fibrosis) that decrease GFR, sudden collapse GFR

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21
Q

markers that may signify renal problems (arterial lesions causing decreased blood flow, sudden collapse GFR) related to scleroderma

A

proteinuria, HTN, azotemia, microangiopathic hemolytic anemia

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22
Q

spots on skin that may appear in scleroderma

A

telangiectasia

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23
Q

band of sclerotic induration and hyperpigmentation occuring on single extremity or face

A

linear scleroderma

24
Q

DDX for scleroderma

A

scleredema, scleromyxedema, eosinophilic fasciitis, toxic syndromes

25
Q

classic triad of fibromyalgia

A

widespread pain (achy/burning in muscle), fatigue, sleep disorder

26
Q

9 trigger points of pain in fibromyalgia (all bilateral)

A

occipital, low cervical, trapezius (midpoint upper border), supraspinatus, 2nd costochondral junction, lateral epicondyle, upper/lateral gluteus, greater trochanter, medial fat pad knee

27
Q

how many pain/trigger points are necessary for diagnosis of fibromyalgia?

A

11/18/2015

28
Q

lab tests that may help look for uderlying causes of fatigue/achiness in fibromyalgia patients

A

CBC (anemia, leukemia), CMP (diabetes, liver, kidney), CPK (muscle breakdown), ESR (inflammation), TSH (Hypo)

29
Q

possible treatments of peripheral pain generators

A

CV exercise, heat/ROM, rubs, manipulative therapies (chiropractic, massage), analgesics/injections

30
Q

meds usually used to treat fibromyalgia

A

tricyclic antidepressants (NE and serotonin reputake inhibitor)

31
Q

responsible for problems associated with scleroderma

A

large amounts of collagen

32
Q

arthritis that affects men and women at same rate

A

psoriatic

33
Q

look for skin changes in these areas for psoriasis

A

periumbilical area, elbow, intragluteal fold, nail pitting

34
Q

these cause symmetric polyarthritis

A

RA and SLE

35
Q

this arthritis involves DIPs

A

OA

36
Q

commonly to see this on hand Xray in psoriatic arthritis

A

pencil in cup deformity

37
Q

enteropathic causes of arthritis

A

ulcerative colitis, Chron’s disease, reactive arthritis, bowel bypass disease, whipple’s disease

38
Q

ulcerative colitis and Chron’s disease have been associated with this kind of arthritis

A

ankylosing spondylitits

39
Q

relapsing syndrome of oral ulceration, genital ulceration, and uveitis –> could cause arthritis

A

Bechet’s disease

40
Q

common finding on Xray in enteropathic arthritis

A

sacroiliitis

41
Q

5 different types of psoriatic arthritis

A

DIP involvement, peripheral asymmetric oligoarthritis, rheumatoid like, arthritis mutilans, sacroiliitis

42
Q

account for 10-30% of nongonoccal bacterial arthritis (usually from skin or soft-tissue infection)

A

B-hemolytic strep

43
Q

gram negative bacteria that most commonly cause septic arthritis in IV drug users

A

S marcescens and P aeurgionsa

44
Q

common gram negative bacteria that cause septic arthritis in elderly (from skin or UTI)

A

E coli

45
Q

aka vertebral body TB

A

Pott’s disease

46
Q

may need this to diagnose TB related septic arthritis

A

synovial biopsy

47
Q

where are organisms located in joint in septic arthritis?

A

subsynovial space

48
Q

clinical features of septic arthritis

A

warm, swollen painful joint with constitutional symptoms

49
Q

arthritis that most resembles septic arthritis (monoarticular)

A

gout and pseudogout

50
Q

treatment for G+ coccal septic arthritis (after aspiration)

A

naficillin or first gen cephalosporin

51
Q

antbiotic for G- cocci (gonnorhea) septic arthritis after aspiration

A

ceftriaxone

52
Q

antibiotic for G- rod septic arthritis

A

aminoglycoside

53
Q

clinical presentation of gonoccal arthritis

A

migratory polyarthralgia (3-5 joints), tenosynovitis, dermatitis, fever

54
Q

DDX for septic arthritis (rash and arthritis)

A

SLE, lyme disease, bacterial endocarditis, N meningitidis

55
Q

typical antibiotic used in disseminated gonococcal infection

A

penicillin

56
Q

these 2 synovial fluid classifications are friable

A

inflammatory and septic

ICM Exam 2 Rheumatology (MC) (5 decks)

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