IC14 SSTI Flashcards
What are the common reasons for SSTIs?
- Disruption of normal host defense
- Overgrowth of microbes and skin invasion
What are the risk factors for SSTIs?
- Disruption (traumatic, non -traumatic, impaired venous and lympatic drainage, peripheral artery diseases)
- Predipsoed conditions (i.e. DM, HIV, transplantation and immunosuppresive medications)
- Cellulitis history
What are ways to prevent SSTIs?
- Managed predisposing conditions
- Maintain skin integrity (i.e. good wound care)
- Acute traumatic wound - debride and irrigation
What is the clinical presentation of impetigo which affects the epidermis?
- Erythematous papules
- Vesicles + pustules
- Honey coloured crusts on erythematous base due to rupturing of no.2
- Well localised
- Common on face and extremities
What is the clinical presentation of ecthyma (ulcerative impetigo) which affects the dermis?
- Itch
- Lesions extends deep into dermis
What is the clinical presentation of furuncle (boil)?
- Infection of hair follicle
- Purulent material extending in SQ tissues
- Abscess
What is the clinical presentation of carbuncles?
- Coalesce of furuncle
- Extend in SQ tissues
What is the clinical presentation of skin abscesses?
- Collection of pus within dermis and deeper skin tissues.
- Abscesses are painful , tender, fluctuant
- erythematous nodules
What is the clincial presentation of cellulitis which affects the SQ fats?
- Acute, diffuse, spreading, non-elevated, poorly demarcated
- Unilateral, rapid progression/ onset and lower extremities
What is the clinical presentation of erysipelas which affects the dermis?
- fiery red, tender
- Painful plagues
- Well demarcated edges
- Common on face and lower extremities
How should culture be collected?
- Deep in wound after surface is cleansed
- Base of closed abscess
- By curettage
When should blood culture be taken?
- Immunocompromised
- Severe cases with marked systemic symptoms of infection
What is the bacteria that causes impetigo?
Staphlococci and Streptococci
What is the bacteria that causes ecthyma?
Group A streptococci
What are the antibiotics option avaiable for impetigo (mild, limited lesions)?
Topical mupirocin BID for 5 days
What are the antibiotics option avaiable for impetigo and ecthyma (multiple lesions)?
PO cephalexin or cloxacillin
Penicillin allergy (PO clindamycin)
Culture directed (S.pyogenes): PO penicillin V, amoxicillin
Culture directed (MSSA): cephalexin or cloxacillin
What is the duration of treatment of impetigo and ecthyma?
5 to 7 days
What is the bacteria that cause non-purulent cellulitis or erysipelas
Commonly β hemolytic streptococcus (group A - S.pyogenes) - common
Others: S.aureus, Aeromonas, vibrio, vulnificus, pseduomonas
What are the antibiotics for mild, non purulent cellutitis and erysipelas?
Penicillin V, Cephalexin, Cloxacillin
Penicillin allergy: Clindamycin
What are the antibiotics for moderate, with some purulence cellutitis and erysipelas?
Cefazolin, cloxacillin
Penicillin allergy: Clindamycin
What are the antibiotics for severe cellutitis and erysipelas?
IV: Piperacillin Tazobactam, cefepime, meropenem
MRSA: IV vancomycin, daptomycin and linezolid
What is the bacteria that causes purulent furuncles, carbuncles, skin abscesses, purulent cellulitis?
S.aureus (main)
Others: β-hemolytic strptococcus, gram neg and anaerobes
What are the components in the SIRS criteria?
Temperature: <36 or > 38 degree celcius
HR: 90bpm
RR: 24 bpm
WBC: >12x10^9/Lor <4x10^9/L
At least 2 out of 4 must be fulfilled
What is the mainstay treatment for purulent SSTIs?
Incision and drainage
When is adjucntive systemic antibiotics given?
- Unable to drain completely
- Lack of response to I&D
- Extensive disease involving several sites
- Extremes of age
- Immunosuppressed
- Signs of systemic illness
- IV if severe