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PR3153 finals > ic12 depression drug & disease interactions > Flashcards

ic12 depression drug & disease interactions Flashcards

1
Q

what to avoid for BPH, NAG (narrow angle glaucoma)

A

TCA
paroxetine

anticholinergic effect
paroxetine most anticholinergic effect of SSRIs.

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2
Q

what to avoid for obesity

A

mirtazapine, TCA, MAOI

effect of serotonin on appetite

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3
Q

what to consider for obesity

A

bupropion, SSRI, SNRI

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4
Q

what to avoid for underweight

A

bupropion

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5
Q

what to consider for underweight

A

mirtazapine

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6
Q

what to avoid for eating disorders

A

bupropion

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7
Q

what to consider for eating disorder

A

fluoxetine

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8
Q

what to consider for cvd

A

sertraline (has antiplatelet effect)

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9
Q

what to avoid for cvd

A

TCA
escitalopram

risk of ECG changes
escitalopram only SSRI w QTC pro- side effects.

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10
Q

what to consider for cerebrovascular accident (stroke)

A

fluoxetine

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11
Q

what to consider for chronic pain/neuropathy

A

SNRI, TCA (structure similar to tramadol)

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12
Q

what to avoid for DM

A

TCA

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13
Q

what to avoid for renal insuff

A

duloxetine

caution paroxetine, vortioxetine

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14
Q

what to avoid for hepatic insuff

A

duloxetine
agomelatine

caution paroxetine, escitalopram

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15
Q

what to avoid for hypertension

A

TCA
SNRI

increase sympathetic tone

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16
Q

what to avoid for seizures

A

TCA
bupropion

17
Q

what to consider for seizures

A

SSRI
SNRI

18
Q

what to avoid in elderly

A

TCA

sedation, risk of hyponatremia and SIADH

19
Q

what to avoid in tamoxifen therapy

A

paroxetine, fluoxetine, bupropion

cyp 2d6 inhibition prevent conversion of tamoxifen to active drug

20
Q

what to consider in tamoxifen therapy

A

venlafaxine
escitalopram

21
Q

what to consider in tobacco use smoking cessation

A

bupropion

22
Q

what to avoid in pregnancy

A

paroxetine
bupropion

23
Q

s/sx of serotonin syndrome

A

Feeling agitated and restless, other mental changes such as hallucination. Heavy sweating, shivering. Fast heart rate, irregular heartbeat.

onset 6-8 hours

24
Q

coadminstration of what kind of drugs increase serotonin syndrome risk?

A

triptans
sibutramine
opioids
linezolid, ritonavir
MAOi + serotonergic antidepressants

25
Q

what food-drug consideration?

A

avoid alcohol
take 4-6 hours apart.

26
Q

what risk does SSRI pose and what to avoid

A

increase risk of bleeding
high risk in elderly on NSAIDs, warfarin, steroids.
consider adding PPI with NSAIDs.

Agomelatine safest.

PR3153 finals (17 decks)

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