IC 3 (geriatric syndromes) Flashcards

1
Q

what is geriatric syndrome

A
  • prevalent in elderly pts (eg frail)
  • impairment in multiple organ system
  • neg impact on FUNCTIONAL, QOL, MORTALITY
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2
Q

frailty definition

A
  • Increases vulnerability to stressors (acute illness, surgery etc) lead to poorer health outcomes
    • Age is no longer considered a defining characteristics.
    • Youth can be frail too
  • Is a syndrome: group of s&sx that aggregate in hierarchical order, may trigger a cascade of alterations across other systems.
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3
Q

physical characteristics (Fried Frailty Tool)

clinical use (need pt participation & specialised equip)

A
  • Weak (poor hand grip strength, difficulty walking up 1 flight staris)
  • Slow walking (>6-7s for 10 feet)
  • Low physical activity
  • Weight loss (≥5% weight loss in last year)
  • Exhaustion (fatigued when performing daily activities)
    □ Pre-frail: 1-2
    □ Frail: >3
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4
Q

frailty associated with

A
  • Longer hosp stay, more post-op complication, greater likelihood of discharge institutionalization (if require surgery)
  • Associated with other comorb and conditions
    □ Polypharmacy
    □ Osteoarthritis
    □ Analgesic use
    □ Heart failure and CVD
    □ Risk of falling
    □ Depressive sx
    □ Cognitive dysfunction
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5
Q

hypothesis model of frailty and adverse health outcomes

A

triggers:

  • oxidative stress, mitochondrial dysfunction, DNA damage, cell senescence
  • gene variation + environ
  • INFLAM DISEASE

–> inflam, neuroendocrine dysregulation

Markers of frailty:

  • (incr) CRP, IL-6, Cortisol
  • (decr) IGF-1 insulin growth factor, DHEA-S dehydroepiandrosterone sulfate

—> clinical frailty (slow, weak, weight loss, low activity, fatigue)

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6
Q

clinical manifestation of frailty (that leads to clinical frailty sx)

A

Negative energy balance
Sarcopenia
immune function decline
cognitive impairment
incr clotting
decr glucose metabolism

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7
Q

clinical frailty scale (SG)

1-9

A

CFS 4 = pre-frail (mild frailty), functionally Independent, but symptoms of chronic illnesses are affecting activity tolerance

CFS 5 = Need assistance for all or some of the iADLs

CFS 6 = Need assistance for all outside activities and some of the bADLs (e.g. dressing ,bathing)

CFS 7 = Clinically stable but FULLY dependent for personal care

CFS 8 = Nearing end of life and FULLY dependent for personal care

CFS 9 = Terminally ill (<6 months) but not severely frail

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8
Q

FRAIL scale (US)

A

fatigue
resistance (climb 1 flight of stairs)
ambulation (walk 80m)
illness (HTN, DM, cancer, chronic lung disease, asthma, HA, CHF, angina, stroke, arthritis, CKD) > 5 =1point
loss of weight (>5% in past year)

Pre-frail: 1-2
Frail: >3

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9
Q

management of frailty

A
  • establish goals ( assessing indiv pt physical, psychological, social and environmental needs)
  • physical exercise/ OT
  • nutritional intake
  • med review
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10
Q

possible cuases of low nutritional intake in frail pts

A
  • Medication side effects
    ○ Suppress appetite, anticholinergics (dry mouth, decr saliva prod – affect swallowing and taste), sense of taste, sedation
  • Depression
  • Access to food
    ○ Financial, physical restriction
  • Require assistance
  • Chewing/ swallowing
    ○ Consistency of food
  • Unnecessary dietary restriction
    ○ Not impt to restrict for frail pts, need energy
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11
Q

med review for frail pts

A
  • DRPs affecting ability to take part in PT/OT and adequate nutritional intake
  • Vit D suppl (bone, muscle, immune system)
  • Explicit criterias (BEERS, STOPP)
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12
Q

fall definition

A

At unexpected event in which a person comes to rest on the ground, floor or a lower surface

  • Mostly multifactorial cases
  • Adverse patient outcomes
    • Pain, fracture, traumatic brain injury
    • Concern about falling (vs fear of falling)
    • Reduced QOL/ functional dependency
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13
Q

routine checkup with HCP

3 key qns

A

1) fall past 12mnth
2) Do you feel steady when you stand/ walk?
3) Any concerns of falling?

yes to any –> further evaluation

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14
Q

when presenting to HCP w/ fall or related injury/ Yes to key qn

A

assess fall severity

  • injury
  • ≥2 fall last yr
  • frailty
  • lie on floor unable to get up
  • loss of consciousness/ suscepted syncope

if yes: HIGH RISK

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15
Q

not high risk –> refer for gait, balance test

A
  • Test:
    □ Timed up and go (>15s)
    □ gait speed ≤ 0.8m/s
    □ Berg balance scale (retrieve object from floor)
    □ Performance-orientated mobility assessment
  • Recommended for:
    □ Persons who report single fall in past 12mnths (early detection of any deficits) to identify indiv who may need multifactorial assessment*

yes = intermediate risk

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16
Q

low fall risk intervention

A

educate on fall prevention
advise on physical activity exercise

f/u 1yr

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17
Q

intermediate fall risk

A

2nd prevention to improve MAJOR RISK FACTOR
* tailored exercise: balance, gait, strength
* educate on fall prevention

f/u 1yr

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18
Q

high fall risk

A

2nd prevention and treatment

  • multifactorial fall risk assessment
  • individualised tailored interventiion…

f/u 30-90d

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19
Q

multifactorial fall risk assessment

A
  • Medication history
    ○ Acute, chronic medical prob (osteoporosis/ UI/ CVD)
  • Disease history
    ○ Cardiovascular disorder
    ○ Contributing disease/ atypical disease presentation
    ○ Depressive disorders
  • Mobility
    ○ Balance, gait, walking air/ footwear/ foot prob
    ○ muscle strength
  • Neurological function (cognitive function, lower extremity peri nerves, proprioception, reflex, test of cortical, extrapyramidal and cerebellar function)
    ○ Cognition, Delirium, Behaviour
  • Sensory function
    ○ Dizzy, vision, hearing
  • Activities of daily living
    ○ Functional ability
  • Autonomic function
    ○ orthostatic hypotension
    ○ Urinary incontinence
  • Nutrition history
    ○ Nutritional status
    ○ Vit D
  • Functional assessment
    ○ Indiv perceived functional ability and fear related to falling
    ○ Any concerns/ activities that contribute to deconditioning
    ○ ADL skills (use of adaptive equip, mobility aids)
  • Environment
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20
Q

intrinsic factors for fall risk

A

lower extremity weakness, previous fall, gait and balance, visual impair, dep, functional and cog impairment, dizzy, low BMI, UI, OH, female, >80yo

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21
Q

extrinsic factors for fall risk

A

polypharm, psychotropic meds, environ hazard, lack safety equip

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22
Q

Identify Falls Risk Increasing Drugs (FRIDS) by mechanism:

A

Sedation

Orthostatic hypotension

Anticholinergics – slow down reaction time, drowsy, blurred vision, confusion

Hypoglycemia

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23
Q

explicit criteria for FRIDS: STOPPFall drug classes

A
  • OH induction: a-blockers, central antihypertensives, vasodilators, diuretics
  • Opioids
  • Psychotropics: antidep, antipsychotics, BZP/ Z-drugs
  • Anticonvulsants
  • Anticholinergics: 1st gen antihistamines, muscle relaxants
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24
Q

dizziness definition

A

Dizziness important geriatric syndrome as it can result in

* Potentially serious etiologies (stroke, MI, traumatic brain injury)
* Incr risk of fall
* Incr risk of deconditioning (period of inactivity, reduced muscle strength)
* Reduced QOL
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25
Q

4 types of dizziness

A
  • Vertigo
    ○ Object spinning/ they are moving
    ○ Benign paroxysmal positional vertigo
  • Pre-syncopal dizziness
    ○ Change in body posture pOH (dizziness goes away when u sit/ lie)
  • Disequilibrium
    ○ Central etiologies
  • Unspecified dizziness
    ○ Older adults can have more than 1 type of dizziness
    ○ Not enough to determine cause
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26
Q

differential dx of dizziness and vertigo

A

peripheral: BPPV, vestibular neuritis, Meniere disease, otosclerosis

central causes: vestibular migraine, CVB, meningiomas

others: psych, med induced, CVS/ metabolic/ OH
20% med related

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27
Q

TiTraTe approach to evaluate dizziness

A

Ti : Timing – Continuous or Episodic (Onset, Freq, Duration)
Tr : Triggers – head movement, posture change, spontaneous, intermittent
TE: Targeted Examination

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28
Q

Episodic Triggered: Dix-Hallpike maneuver

A

Positive: Benign Paroxysmal Positional Vertigo
Negativedap-like maneuver trigger: Orthostatic Hypotension

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29
Q

Episodic Spontaneous: further history

A

Unilateral hearing loss/sensation of ear fullness: Meniere Disease

Migraine Headache: Vestibular Migraine

Psychiatric symptoms: Panic attack, etc

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30
Q

Continuous vestibular

A

Trauma/toxin (drugs)

31
Q

Spontaneous: HINTS Exam [Head Impulse/Nystagmus/Test of Skew]

A

Central: Stroke/TIA
Peripheral: Vestibular neuronitis

32
Q

main 7 types of dizziness

after exlcuding serious and dangerous causes

A
  • Benign paroxysmal positional vertigo (crystals loose)
  • Orthostatic hypotension (med, dehydrate, neurogenic)
  • Meniere’s Disease (fluid in inner ear)
  • Vestibular migraine
  • Psychogenic dizziness (mood disorder)
  • Drug-induced dizziness
  • Vestibular neuronitis (inflammation)
33
Q

vestibular suppressants indicated for __

A
  • only if vestibular symptoms are prolonged (>30 mins) PO drugs take time to onset
  • Almost all are Beers List drugs. Timely review and assess risk-benefit. Threshold to stop should be low
34
Q

med classes for dizziness

A
  • Strong anticholinergic effects
    ○ Antihistamine (1st gen): diphenhydramine/ dimenhydrinate/ meclizine
    ○ Phenothiazines: prochlorperazine/ promethazine
    ○ Anticholinergics: scopolamine (hyoscine hydrobromide)
  • Benzodiazepine
    ○ Lorazepam/ diazepam/ clonazepam
  • Antidopaminergic (anti-emetic effect)
    ○ Metoclopramide, ondansetron, prochlorperazine
  • Calcium channel antagonists
    ○ Cinnarizine, flunarizine
  • Histamine analogues
    ○ Betahistine (well tolerated)
35
Q

Strong anticholinergic effects
for sx relief of dizzy

A
  • Antihistamine (1st gen): diphenhydramine/ dimenhydrinate/ meclizine
  • Phenothiazines: prochlorperazine/ promethazine
    ○ CI: PD, parkinsonism due to added antidopaminergic effects
  • Anticholinergics: scopolamine (hyoscine hydrobromide)
    ○ Not hyoscine butylbromide (don’t cross BBB, antispasmolytic)
36
Q

Benzodiazepine

A

Lorazepam/ diazepam/ clonazepam
* Not commonly used for elderly in sg (short term)
* SE: more sedating, fall risk (slower reaction), cognitive impairment, depression

37
Q

antidopaminergic (anti-emetic)

A

Metoclopramide
CI: parkinsonism, PDD, PLB – use ondansetron

38
Q

Calcium channel antagonists

A

Cinnarizine, flunarizine

  • MOA: incr circulation in cochlear
  • SE: sedating, weight gain (antiH effect), risk movement disorder (caution in Parkinsonism)
39
Q

Histamine analogues

A

Betahistine (well tolerated)

  • MOA: H3 receptor antagonist, H1 partial agonist, H2 negligible agonist
  • Caution: asthma (H1 agonist cause bronchospasm), monitor
  • CI: active or hist of PUD
40
Q

delirium definition

A

Acute neuropsychiatric disorders associated with medical conditions, medications, and/or substance intoxications
(excess Dopamine, deplete Ach)

* Geriatric medical emergency 
	○ Incr mortality
	○ More severe functional decline
*  But usually reversible. Has sudden onset, fluctuates and is characterized by inattention and disorganised thoughts and speech.
41
Q

2 types of delirium

A
  • Hyperactive delirium
    ○ Restless, agitation (resist care, climb out of bed, pull out IV/ catheter)
    ○ Inattention
    ○ Psychosis (delusions/ hallucinations)
  • Hypoactive delirium
    ○ Slow response, incr sedation , lethargy and apathetic
    ○ More difficult to identify
42
Q

risk factor for delirium

A
  • Age ≥65yrs
  • Cognitive impairment (past/ present) and/ or dementia
  • Current hip fracture
  • Severe illness
43
Q

possible causes for delirium

I WATCH DEATH

A
  • INFECTIONS: encephalitis, meningitis, UTI, pneumonia
  • WITHDRAWAL: alcohol, barbiturates, BZP.
    ○ (atropine – tachy); (benzhexol – NMS, confusion)
  • ACUTE METABOLIC DISORDER: electrolyte imbalance, hep, renal failure
  • TRAUMA: head injury, postop
  • CNS PATHOLOGY: stroke, hemorrhage, tumor, seizure disorders, Parkinson’s
  • HYPOXIA: anemia, cardiac failure, pul embolus
  • DEFICIENCIES: vit B12, folic acid, thiamine
  • ENDOCRINOPATHIES: thyroid, glucose, parathyroid, adrenal
  • ACUTE VASCULAR : shock vasculitis, HTN, encepahalopathy
  • TOXINS, substance use, MED (alcohol, anesthetics, narcotics
  • HEAVY METALS: arsenic, lead, mercury
44
Q

screening for delirium
4 AT (sg)
CAM

A
  • alertness
  • abbreviated mental test 4 (AMT4): DOB, age, place, current year
  • attention (count backwards, 30-3-3-3)
  • acuity
45
Q

diagnosis of delirium

A
  • Physical Examination
    • Vitals signs
    • Hydration Status
    • Skin conditions
    • Potential Infection foci
  • History [Caregiver/Family member]
  • Labs/Imaging Studies
46
Q

prevention of delirium

A
  • Sensory functions optimisations
  • Hydration/nutrition
  • Bowel movement/urination
  • Early mobility
  • Pain control
  • Medication review !!!!!!
  • Social interaction with loved ones
  • Reorientation with clock/calendar/proper lighting
  • Conducive environment
  • Promote good sleep
  • Address infection/hypoxia
47
Q

approach to tx of pt with delirium

A
  1. Prevent delirium (for at-risk pts)
  2. Monitor cognitive function (4AT, CAM-ICU, ICDSU assessment)
  3. Perform cognitive assessment and evaluate for delirium
  4. Delirium confirmed
  • Identify and address predisposing and precipitating factors
  • Review meds, vital signs, hx, physical and neurological examination, labs
48
Q

management of delirium

A

1) initiate supportive measures
2) Manage symptoms of delirium
3) compromise safety? px

49
Q

1) initiate supportive measures

A

hydrate
avoid restraints
mobilise pt
reduce noise
orienting stimuli (time, calender etc)
reassurance
manage pain

  • tx underlying medical conditions (anticholinergic drug use, CNS drugs, glucose, electrolyte, Abx regimen)
  • Airway, volume status, nutritional support, pressure sores, mobilisation, DVT
50
Q

2) Manage symptoms of delirium

A
  • Non-pharm: for agitation (music, massage), maintain mobility and self care ability, sleep-wake cycle, family involvement
    * Avoid physical restraint, catheter
  • Pharm: reserve for severe agitation (harm, safety hazard)
    * Low dose, adjust until effect achieved
    * Maintain effective dose for 2-3 days
51
Q

pharm for agitation

A
  • APS (low anti-D effect/ PD friendly preferred) Quetiapine > olan > halo
  • BZP (1st line for alcohol/Benzo withdrawal; Alt if APS not safe)
    lorazepam PO/IV/SC 0.5-1mg
52
Q

APS for agitation

(incr Ach? not promising, incr mortality)

A

Atypical

  • Quetiapine PO 6.25-12.5mg BD ~ 100mg/day
    * PD friendly + antihistamine effect (drowsy), less Qtc, EPSE
    * Low anti-dopaminergic effect, not useful in pt with underlying schizo, unable to control agitation
  • Olanzapine PO (orodispersible) 1.25 - 2.5mg~ 10mg/d
    QTc safe

Typical

  • Haloperidol SC/IM/PO 0.3 - 1mg BD ~ 5g/day (non-ICU)
    CI: prolonged QTc, parkinsonism (DLB, PDD) - EPSE
53
Q

ICU delirium

A

Typical APS
* Haloperidol ICU: 15mg IV

anxiolytics
* Dexmedetomidine (sedative agent) IV

54
Q

hypoactive delirium

A

Do not treat hypoactive delirium (withdraw CNS suppressants, treat underlying cause)

55
Q

urinary continence prerequisites (opp of UI)

A
  • Normally functioning lower urinary tracts
  • Adequate physical and cognitive functions to use toilets

Good urinary tract, body and brain

56
Q

normal physiology of LUT

A

Bladder filling phase
a. Sympathetic NS activated (fight-flight) + PNS blocked
i. Activate b3 adrenergic receptor –> detrusor muscle relax (bladder fill)
ii. Activate b1 adrenergic receptor –> tighten bladder outlet/ urethra (prevent leak)

Bladder voiding phase
a. SNS blocked + Parasympathetic NS activated (rest-digest)
i. Activate M3 receptor in bladder –> bladder contract

57
Q

5 types of UI

A

stress
urge
overflow
functional
mixed

58
Q

stress UI

sx: leak with cough, sneeze, exercise
void diary: 5-10ml w/ activity
cough stress test
PVR < 50ml

A
  • Involuntary loss of urine (small vol) with incr intraabdominal pressure (cough, laugh, exercise)
    • Weak pelvic floor muscle
      (childbirth, preg, menopause/ low E = low muscle)
    • Bladder outlet or urethral sphincter weakness
      (Post-urologic surgery)
59
Q

urge UI

sx: urgency
void diary: variable vol loss, freq and nocturia
cough stress test show DELAYED LEAK
PVR < 50ml

A

Leakage of urine (can be large vol) because of inability to delay voiding after sensation of bladder fullness is perceived

  • Sensory:
    □ Detrusor overactivity (2* to BPH, sensitive bladder)
    □ Local genitourinary conditions, irritation, inflamm (tumor, stones, diverticula, outflow ob)
    - Need urinalysis lab results
  • Neurologic: CNS disorder inability for cerebral inhibition of detrusor contract (stroke, parkinsonism, dementia, spinal cord injury)
60
Q

overflow UI

sx: no sx with PA, urgency
void diary: varies
cough stress test: NIL
PVR >200ml

A

Leakage of urine (small vol) caused by either mechanical forces on an overdistended bladder (from stress leak?) or other urinary retention on bladder and sphincter function (cause urge leak)

  • Obstruct outflow
    □ Prostate (BPH), stricture, cystocele
  • Neurogenic, unable to contract bladder
    □ Underactive bladder. Sclerosis, spinal cord lesions
    □ Acontractile bladder a/w DM, spinal cord injury
  • Medication effect
61
Q

functional UI

sx: cog. impair/ degree of immobility
void diary: may have pattern in circumstances
cough stress test: NIL
PVR varies

A

Cognitive, functional or mobility difficulties. (no failure in blader function or neurologic control of urination)

  • Toileting difficulty
  • psychological unwillingness, environmental barriers
  • Severe dementia, other neurologic disorder
    □ Don’t know what to do when there is urge
  • Psychological factors (depression, hostility)

No good body/ brain

62
Q

3 UI qn to identify cause

A
  • during the past 3mnths have you leaked urine?
  • did you leak urine: due to Physical activity (cough, sneeze)/ urge but cannot get to toilet fast enough/ no PA no Urgency
  • leak most urine when: due to Physical activity (cough, sneeze)/ urge but cannot get to toilet fast enough/ no PA no Urgency/ about equal PA as urgency

PA: stress
urge: urge
equal: mixed
without: other causes…

63
Q

DIAPPERS ddx for UI

A

Delirium
Infection (UTI)
Atrophic vaginitis
Pharmaceuticals
Psychological disorder (DEP)
Excess urine output (DM)
Reduced mobility (funct) or reversible/ drug urinary retention
Stool impact

64
Q

dx of UI

A

1) assess for transient incontinece (DIAPPERS, med)
* treat reversible causes

2) assess for chronic incontinence (hx, 3 qn, voiding diary, physical exam - cough stress, PVR, lab)

3) presume type of UI

65
Q

management of UI

A
  • Address underlying cause(s), if any
  • Non-Pharmacological treatments
    • First line, to continue even if on medications. [cognition and motivation]
    • Lifestyle modifications> Wt loss, normal bowel habit, reduce bladder irritants, water hygiene
    • Bladder Retraining
    • Kegel’s pelvic floor muscle exercise [SUI and UUI]
    • Timed voiding [for patients who are functionally dependent]
    • Continent products
66
Q

voiding diary

A
  • Freq of incontinence ep, amt of fluid intake, vol urination
    ○ Clarify type of incontinence
    ○ Act as baseline on severity, assess effectiveness of treatment
67
Q

physical exam and lab test

A
  • Physical examination
    • Signs of vol overload, palpate for mass/ tenderness, extremities function, prostate exam.
    • Cough stress test
  • Labe test:
    • Postvoid residual urine: >200ml (overflow)
    • normal is <50ml
68
Q

manage stress UI

A
  • Kegel’s exercise
  • Topical estrogen [may take up to 3 months for action onset, need counseling]
  • Duloxetine, esp if depression present but not for patients with crcl <30 ml/min
  • Surgery/Devices
69
Q

manage UUI

A
  • Kegel’s exercise
  • Treat BPH [men]
  • Topical estrogen [delayed onset]
  • β- 3 adrenergic receptor agonist
    • mirabegron, vibegron
  • Antimuscarinic agents
    • anticholinergic side effects
    • prefer M3-selective agents such as solifenacin and darifenacin
  • Botulinum toxin injection
  • Sacral nerve stimulation etc
70
Q

manage OUI

A

Bladder outlet obstruction
* Men: treat underlying cause (BPH, stricture, malignancy, stone etc)
* Female: usually structural (uterine prolapse)

Bladder underactivity
* Men: bethanecol (cholinergic), clean intermittent catherisation (spinal cord injury)
* Female: clean intermittent catherisation +/- bethanecol (cholinergic)

71
Q

UI red flags for referral

A

UI w/ relapse or recurrent sx UTI
new onset of sx (muscle weak)
marked prostate enlargement
pelvic organ PROLAPSE
pelvic pain
hematuria, proteinuria, PVR >200ml
pelvic surgery, radiation
uncertain diagnosis

72
Q

types of elder abuse :(

A
  • Physical (chemical/ physical restraint)
    □ Dope pt to be sedated for long period of time –> deconditioned (pressure ulcers, deterioration in health, muscle, pneumonia)
  • Sexual
  • Psychological
  • Neglect (intentional, ignorance)
    □ Withhold proper treatment
    □ Diversions (sell/ take the meds themselves)
  • Financial $$
73
Q

risk for elder abuse in these older adults

A

Dementia (esp BPSD –> CAREGIVER STRESS)
Physical disability
Poor relationship with caregiver pre-morbidly (use to abuse them?)

74
Q

risk factors in prepetrator

A
  • Caregiver dependent on victims for material gains (financial abuse) – food, shelter, money
  • Caregiver with mental health issues
    □ Depression
    □ Substance use disorders (neglect: take elderly opioids)
  • Caregiver who feels overwhelmed (overworked, underpaid)
  • Caregiver who is victim of domestic violence