IBS-D

Question 1

IBS-D treatment options

Answer 1

rifaximin (xifaxan)
eluxadoline (viberzi)
elosteron

Question 2

rifaximin moa

MOA use dose

Answer 2

ABX, poorly absorbed, stays in GIT
use: (+) breath test SIBO (small intestine bacterial overgrowth)
550mg po tid x14d, can repeat up to 2x

Question 3

eluxadoline (viberzi) MOA

Answer 3

mu agonist, gamma antag, kappa ag, inhibits bowel contraction

Question 4

eluxadoline (viberzi) AE CI

Answer 4

AE: sphincter of oddi dysfunction (spasm)
CI: hx pancreatitis, alcoholism or current
no gall bladder, pts who AEingest >/= 3 alcoholic beverages a day

Question 5

elosteron MOA

Answer 5

5HT3 antag dec transit time and increases H2O reabs from colon to body, dec stool liquidity

Question 6

elosteron uses

Answer 6

IBS-D who failed conventional tx (xifaxan or viberzi)

only approved for women who failed conventional and have severe IBS-D

Question 7

elosteron AE

Answer 7

severe constipation, ischemic colitis (REMS!)