IBD

Question 1

Sulfasalazine

Answer 1

Anti-inflammatory

MOA: Work from lumen to reduce inflammation

Acute therapy for inflammatory bowel disease

Question 2

Olsalazine

Answer 2

Anti-inflammatory

MOA: Work from lumen to reduce inflammation; 5-ASA dimer

Acute therapy for inflammatory bowel disease

SE: Less toxicity than sulfasalzine

Question 3

Mesalamine

Answer 3

Anti-inflammatory

MOA: Work from lumen to reduce inflammation

Acute therapy for inflammatory bowel disease

Delayed release 5-ASA, for terminal ileum, colon

Question 4

Prednisone (Decadron)

Answer 4

Corticosteroid

Acute IBD, chronic IBD

Question 5

Azathioprine (Imuran)

Answer 5

Immunosupressive

MOA: Purine antimetabolite; interferes with DNA synthesis

Chronic therapy for IBD

Question 6

Cyclosporine

Answer 6

Immunosupressive

MOA: Suppresses T helper and T suppressor lymphocytes

Chronic therapy for IBD

Question 7

Methotrexate (Trexall)

Answer 7

Immunosupressive

Decreases synthesis of inflammatory mediators

Chronic therapy for IBD

Question 8

Infliximab (Remicade); adalimumab; certolizumab

Answer 8

MAb Immunosupressive

Binds and neutralizes TNFa

Chronic therapy for IBD

Question 9

Natalizumab; vedolizumab; ustekinumab

Answer 9

MAb Immunosupressive

Binds to a4-integrin, prevents immune cells from invading tissue

Chronic therapy for IBD