IBD

Question 1

IBD definition:

Answer 1

dysregulated inappropriate response of the intestinal mucosal immune system to otherwise innocuous luminal antigens in a genetically susceptible host

Question 2

2 main types IBD?

Answer 2

UC

CD

Question 3

UC definition?

Answer 3

mucosal ulceration in colon

Question 4

CD defintiion?

Answer 4

transmural inflammation in any part of GI system (usually distal ileum and R side colon)

Question 5

Spread of inflammation in UC?

Answer 5

affects continuously - not patchy

Question 6

Spread of inflammation in CD?

Answer 6

patchy

Question 7

*patient who smoke are less likely to get? moer likely to get?

Answer 7

less UC

more CD

Count me in! get me a cigarette!

Question 8

3 main factors for IBD pathogenesis?

Answer 8

luminal antigens
genetics - NOD2 mutation
environmental triggers

Question 9

TH1 t-cell response seen in:

Answer 9

Cell-mediated granulomas (CD or celiac)

IFN gamma
IL2
TNF

Question 10

TH2 t-cell response seen in:

Answer 10

hypersenitivity - food allergy, worm inf, UC?

IL4
IL5
IL10

Question 11

Proinflammatory cytokines:

Answer 11

TNF
IL1beta
IL6
IL12
IL18
IL4
IFNgamma

Question 12

Antiinflammatory cytokines:

Answer 12

IL10
TGFbeta
IL1Ra
IL13
PGE2
PGI2

Question 13

see fistula in patient so you know its which disease?

Answer 13

CD!

Question 14

Hallmark of CD

Answer 14

non-caseating granuloma

Question 15

gold standard test for CD?

Answer 15

MR interography

Question 16

typical look of colon mucosa with CD?

Answer 16

cobblestone!

Question 17

Which IBD has rectal sparing?

Answer 17

CD!

Question 18

IBD extraintestinal manifetations:

Answer 18

apthous stomatitis
episcleritis and uveitis
arthritis
vascular complications (clotting)
E Nodosum
P gangrenosum
BONE DISEASE

Question 19

more inflammation cytokines with which IBD?

Answer 19

more with CD!

Question 20

IBD peripheral arthritis:

• affects whihc joints?
• how does it affect?

Answer 20

• large joints
• monoarticular
• asymmetric
• no synovial destruction
• seroneg

Question 21

UC and liver complication:

Answer 21

primary sclerosing cholangitis –

Question 22

only sulfa -related toxicity?

Answer 22

male infertility
hemolytic anemia
agranulocytosis

Question 23

Sulfa and 5ASA toxicity?

Answer 23

alveolitis

pancreatitis

Question 24

5ASA toxicity

Answer 24

nephritis

Question 25

Sullfa much more often that 5ASA toxicity?

Answer 25

Rash
fever
headahce
nausea
dyspepsia
neutropenia
hepatitis

Question 26

Highest risk drugs to use for IBDs:

Answer 26

steroids and narcotics