I.B. DRUG RECEPTORS & PHARMACODYNAMICS Flashcards
Actions/effects of the drug on the body
PHARMACODYNAMICS
Specific molecules in a biologic system with which drugs interact to produce changes in the function of the system
RECEPTORS
Specific binding region of the macromolecule
RECEPTOR SITE/RECOGNITION SITE
is the fundamental event that initiates the action of the drug
Interaction between the drug and the receptoR
CLASSIFICATION OF RECEPTORS (4)
REGULATORY PROTEINS
ENZYMES
TRANSPORT PROTEINS
STRUCTURAL PROTEINS
subserve specific physiologic functions
REGULATORY PROTEINS
catalyzes/facilitates metabolic
processes
ENZYMES
usually in the cell membrane, the raw materials of our metabolism is needed to be transported into the cell because we metabolize inside the cell.
TRANSPORT PROTEINS
would be the cytoskeleton
or framework, cellular anatomy
STRUCTURAL PROTEINS
Best characterized drug receptors
REGULATORY PROTEINS
Mediates the action of endogenous chemical signals like neurotransmitters, autacoids and hormones
REGULATORY PROTEINS
Inhibited (or less commonly, activated) by binding a
drug.
ENZYMES
Molecules that translate the drug-receptor interaction into a change in cellular activity
EFFECTOR
Some receptors are also effectors
T/F
true