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Step 3 MTB > I.1. Infectious Diseases > Flashcards

I.1. Infectious Diseases Flashcards

1
Q

I.1.a Intro to antibiotics

A

blank

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2
Q

MSSA IV tx

A

Oxacillin
Nafcillin
Cefazolin (1st gen)

Better than Vanc IV!

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3
Q

MSSA PO tx

A

Dicloxacillin

Cephalexin (1st gen)

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4
Q

MRSA

severe tx

A 
Vancomycin
Telavancin
Daptomycin
Linezolid
Ceftaroline
Tigecycline
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5
Q

MRSA

Minor infection

A

“BCD”
Bactrim (Trimethoprim/Sulfamethoxazole)
Clindamycin
Doxycycline

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6
Q

Linezolid adverse effect

A

Thrombocytopenia

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7
Q

Daptomycin adverse effect

A

Myopathy; elevated CPK

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8
Q

Telavancin?

A

Derivative of Vancomycin; similar efficacy

Bacterial lipopolysaccharide

Inhibits bacterial Cell wall synthesis by binding D-Ala-D-Ala terminus of peptidoglycan

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9
Q

MOA Ceftaroline

A

covers MRSA

inhibits cell wall synthesis by binding PCN-binding protein

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10
Q

MOA Linezolid

A

Protein synthesis inhibition

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11
Q

MOA Bactrim

A

Folate antagonist

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12
Q

If pt has PCN allergy = Rash, can you use cephalosporin?

A

YES

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13
Q

If PCN allergy = anaphylaxis, what can you use?

A

Macrolides (azithromycin, Clarithromycin)

Clindamycin

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14
Q

Meds specific for Strep?

A

Penicillin
Ampicillin
Amoxicillin

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15
Q

Examples of GNB

A 
E coli
Enterobacter
Citrobacter
Morganella
Pseudomonas
Serratia
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16
Q

PCNs great at GNB coverage

A

Piperacillin/tazobactam (Zosyn)

Ticarcillin/clavulonate (Timentin)

17
Q

Cephalosporins great at GNB coverage

A

Cefepime

Ceftazidime

18
Q

Monobactam great at GNB coverage

A

Aztreonam

19
Q

Carbapenems great at GNB coverage

A

Meropenem
Doripenem
Imipenem
Ertapenem

20
Q

Quinolones great at GNB coverage

A

Ciprofloxacin
Levofloxacin
Gemifloxacin
Moxifloxacin

21
Q

Aminoglycosides great at GNB coverage

A

Gentamycin
Amikacin
Tobramycin

22
Q

Ertapenem exception

A

No Pseudomonas coverage

Note: given IV qd; Meropenem IV q8h

23
Q

What do zosyn and timentin cover?

A

GNB, Anaerobes, strep

NOT MRSA!

24
Q

What FQs cover Strep pneumoniae (pneumococcus)?

A

Levo, Gemi, and Moxi-floxacin

25
Q

What FQ does NOT cover strep pneumo?

A

Cipro!

26
Q

How are aminoglycosides often used clinically?

A

With other agents against staph and enterococcus; b/c synergistic effects

Step 3 MTB (1 decks)

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