I.1. Infectious Diseases Flashcards
I.1.a Intro to antibiotics
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MSSA IV tx
Oxacillin
Nafcillin
Cefazolin (1st gen)
Better than Vanc IV!
MSSA PO tx
Dicloxacillin
Cephalexin (1st gen)
MRSA
severe tx
Vancomycin Telavancin Daptomycin Linezolid Ceftaroline Tigecycline
MRSA
Minor infection
“BCD”
Bactrim (Trimethoprim/Sulfamethoxazole)
Clindamycin
Doxycycline
Linezolid adverse effect
Thrombocytopenia
Daptomycin adverse effect
Myopathy; elevated CPK
Telavancin?
Derivative of Vancomycin; similar efficacy
Bacterial lipopolysaccharide
Inhibits bacterial Cell wall synthesis by binding D-Ala-D-Ala terminus of peptidoglycan
MOA Ceftaroline
covers MRSA
inhibits cell wall synthesis by binding PCN-binding protein
MOA Linezolid
Protein synthesis inhibition
MOA Bactrim
Folate antagonist
If pt has PCN allergy = Rash, can you use cephalosporin?
YES
If PCN allergy = anaphylaxis, what can you use?
Macrolides (azithromycin, Clarithromycin)
Clindamycin
Meds specific for Strep?
Penicillin
Ampicillin
Amoxicillin
Examples of GNB
E coli Enterobacter Citrobacter Morganella Pseudomonas Serratia
PCNs great at GNB coverage
Piperacillin/tazobactam (Zosyn)
Ticarcillin/clavulonate (Timentin)
Cephalosporins great at GNB coverage
Cefepime
Ceftazidime
Monobactam great at GNB coverage
Aztreonam
Carbapenems great at GNB coverage
Meropenem
Doripenem
Imipenem
Ertapenem
Quinolones great at GNB coverage
Ciprofloxacin
Levofloxacin
Gemifloxacin
Moxifloxacin
Aminoglycosides great at GNB coverage
Gentamycin
Amikacin
Tobramycin
Ertapenem exception
No Pseudomonas coverage
Note: given IV qd; Meropenem IV q8h
What do zosyn and timentin cover?
GNB, Anaerobes, strep
NOT MRSA!
What FQs cover Strep pneumoniae (pneumococcus)?
Levo, Gemi, and Moxi-floxacin
What FQ does NOT cover strep pneumo?
Cipro!
How are aminoglycosides often used clinically?
With other agents against staph and enterococcus; b/c synergistic effects
