I - Topnotch Pharma Flash Cards - Autonomics
rapidly hydrolyzed by AChE
Acetylcholine (TOPNOTCH)
resistant to AChE
Betanechol (TOPNOTCH)
for Bladder and bowel atony
Betanechol (TOPNOTCH)
Nonselective muscarinic and nicotinic agonist , used topically for glaucoma treatment
Carbachol (TOPNOTCH)
Partial muscarinic agonist; used for treatment of Glaucoma, Sjogren’s syndrome and Sicca syndrome
Pilocarpine (TOPNOTCH)
Adverse Effects of Acetylcholine
CNS stimulation, miosis, cyclospasm, brochoconstriction, excessive GI and GU smooth muscle contraction, increased secretory activity of sweat gland, airways etc, vasodilation (TOPNOTCH)
activates autonomic post ganglionic neurons (both sympathetic and parasympathetic) and skeletal muscle neuromuscular end plants
Nicotine(TOPNOTCH)
used exclusively for smoking cessation
Varenicline (TOPNOTCH)
for Myasthenia gravis diagnosis (Tensilon test)
Edrophonium (TOPNOTCH)
for Myasthenia gravis treatment; reversal of nondepolarizing muscular blockade
Neostigmine (TOPNOTCH)
Long Acting Cholinesterase Inhibitors used as Scabicide and Insecticide
Malathion, Parathion (TOPNOTCH)
Competitively blocks all muscarinic receptors, antagonizes histamine and serotonin ; for motion sickness, dec. acid secretion in the GIT
Scopolamine (TOPNOTCH)
DOC for organophosphate poisoning
Atropine (TOPNOTCH)
for bradycardia, hypersalivation and to decrease airway secretion during general anesthesia
Atropine (TOPNOTCH)
Mydriatic, cycloplegic in eye examinations
Homatropine, Cyclopentolate, Tropicamide (TOPNOTCH)
Competitive nonselective antagonist at muscarinic receptors ; for BA and COPD, not as effective as SABAs but less tachycardia and arrhythmia
Ipratropium, Tiotropium (TOPNOTCH)
Nonselective muscarinic antagonist which reduces detrussor smooth muscle tone spasms
Oxybutinin (TOPNOTCH)
for decreasing urgency in mild cystitis and dec. bladder spasm after urologic surgery
Oxybutinin (TOPNOTCH)
Usual antidote for early stage (48h) cholinesterase inhibitor poisoning, Must be administered before 6-8 hours of organophosphate bond with cholinesterase occurs
Pralidoxime (TOPNOTCH)