I - Topnotch Pharma Flash Cards - Autonomics

Question 1

rapidly hydrolyzed by AChE

Answer 1

Acetylcholine (TOPNOTCH)

Question 2

resistant to AChE

Answer 2

Betanechol (TOPNOTCH)

Question 3

for Bladder and bowel atony

Answer 3

Betanechol (TOPNOTCH)

Question 4

Nonselective muscarinic and nicotinic agonist , used topically for glaucoma treatment

Answer 4

Carbachol (TOPNOTCH)

Question 5

Partial muscarinic agonist; used for treatment of Glaucoma, Sjogren’s syndrome and Sicca syndrome

Answer 5

Pilocarpine (TOPNOTCH)

Question 6

Adverse Effects of Acetylcholine

Answer 6

CNS stimulation, miosis, cyclospasm, brochoconstriction, excessive GI and GU smooth muscle contraction, increased secretory activity of sweat gland, airways etc, vasodilation (TOPNOTCH)

Question 7

activates autonomic post ganglionic neurons (both sympathetic and parasympathetic) and skeletal muscle neuromuscular end plants

Answer 7

Nicotine(TOPNOTCH)

Question 8

used exclusively for smoking cessation

Answer 8

Varenicline (TOPNOTCH)

Question 9

for Myasthenia gravis diagnosis (Tensilon test)

Answer 9

Edrophonium (TOPNOTCH)

Question 10

for Myasthenia gravis treatment; reversal of nondepolarizing muscular blockade

Answer 10

Neostigmine (TOPNOTCH)

Question 11

Long Acting Cholinesterase Inhibitors used as Scabicide and Insecticide

Answer 11

Malathion, Parathion (TOPNOTCH)

Question 12

Competitively blocks all muscarinic receptors, antagonizes histamine and serotonin ; for motion sickness, dec. acid secretion in the GIT

Answer 12

Scopolamine (TOPNOTCH)

Question 13

DOC for organophosphate poisoning

Answer 13

Atropine (TOPNOTCH)

Question 14

for bradycardia, hypersalivation and to decrease airway secretion during general anesthesia

Answer 14

Atropine (TOPNOTCH)

Question 15

Mydriatic, cycloplegic in eye examinations

Answer 15

Homatropine, Cyclopentolate, Tropicamide (TOPNOTCH)

Question 16

Competitive nonselective antagonist at muscarinic receptors ; for BA and COPD, not as effective as SABAs but less tachycardia and arrhythmia

Answer 16

Ipratropium, Tiotropium (TOPNOTCH)

Question 17

Nonselective muscarinic antagonist which reduces detrussor smooth muscle tone spasms

Answer 17

Oxybutinin (TOPNOTCH)

Question 18

for decreasing urgency in mild cystitis and dec. bladder spasm after urologic surgery

Answer 18

Oxybutinin (TOPNOTCH)

Question 19

Usual antidote for early stage (48h) cholinesterase inhibitor poisoning, Must be administered before 6-8 hours of organophosphate bond with cholinesterase occurs

Answer 19

Pralidoxime (TOPNOTCH)

Question 20

Competitively blocks all Nn nicotinic Ach receptors ; for Hypertensive emergencies (obsolete)

Answer 20

Hexamethonium, Mecamylamine, Trimethaptan (TOPNOTCH)

Question 21

DOC for Anaphylaxis

Answer 21

Epinephrine (TOPNOTCH)

Question 22

used for Cardiac arrest, anaphylaxis, asthma, COPD, Hemostasis

Answer 22

Epinephrine (TOPNOTCH)

Question 23

for cardiogenic Shock and heart failure

Answer 23

Norepinephrine (TOPNOTCH)

Question 24

causes vasodilation in splanchnic and renal blood vessels ; for cardiogenic Shock and heart failure

Answer 24

Dopamine (TOPNOTCH)

Question 25

Beta nonselective sympathomimetic, for Asthma

Answer 25

Isoproterenol (TOPNOTCH)

Question 26

SE: Rebound nasal congestion, hypertension, stroke, MI

Answer 26

Phenylephrine (TOPNOTCH)

Question 27

A2 agonist, for Hypertension, Cancer pain, opioid withdrawal

Answer 27

Clonidine (TOPNOTCH)

Question 28

Sedation, rebound hypertension, dry mouth

Answer 28

Clonidine (TOPNOTCH)

Question 29

Sedation, positive Coomb's test (Hemolytic anemia)

Answer 29

Methyldopa (TOPNOTCH)

Question 30

A2 agonist; reserved for ophthalmologic use in glaucoma for reduction of intraocular pressure

Answer 30

Apraclonidine, Brimonidine (TOPNOTCH)

Question 31

B1 agonist, for cardiogenic shock and acute heart failure

Answer 31

Dobutamine (TOPNOTCH)

Question 32

DOC as Asthma reliever, Rapid development of tolerance

Answer 32

Albuterol/Salbutamol (TOPNOTCH)

Question 33

D1 agonist, for Hypertension

Answer 33

Fenoldopam (TOPNOTCH)

Question 34

D2 agonist, restores dopamine actions in the CNS for Parkinson's disease, prolactinemia

Answer 34

Bromocriptine (TOPNOTCH)

Question 35

Irreversibly blocks A1 and A2 receptors resulting to indirect baroreflex activation

Answer 35

Phenoxybenzamine (TOPNOTCH)

Question 36

Reversible A1 and A2 receptor antagonist, for Pheochromocytoma and Rebound hypertension

Answer 36

Phentolamine (TOPNOTCH)

Question 37

Blocks A1, for Benign Prostatic Hyperplasia, Hypertension

Answer 37

Prazosin, Doxazosin, Terazosin (TOPNOTCH)

Question 38

Slightly selective A1a blockade causing relaxation of prostatic smooth muscles > vascular smooth muscle ; for BPH

Answer 38

Tamsulosin (TOPNOTCH)

Question 39

Beta blockade > A1 blockade

Answer 39

Labetalol (TOPNOTCH)

Question 40

Blocks B1 and B2 receptors

Answer 40

Propranolol, Nadolol, Timolol (TOPNOTCH)

Question 41

B1 > B2 blockade

Answer 41

Metoprolol, Atenolol, Alprenolol, Betaxolol, Nebivolol (TOPNOTCH)

Question 42

B1, B2 with intrinsic sympathomimetic (partial agonist) effect

Answer 42

Pindolol, Acebutolol, Carteolol, Bopindolol, Oxprenolol, Celiprolol, Penbutolol (TOPNOTCH)

Question 43

Beta blockade > A1 blockade

Answer 43

Carvedilol, Medoxalol, Bucindolol, Labetalol (TOPNOTCH)

Question 44

B1 > B2 blockade; for rapid control of BP and arrhythmias, thyrotoxicosis and myocardial ischemia intraoperatively ; for Supraventricular tachycardia

Answer 44

Esmolol (TOPNOTCH)

Question 45

BB with direct vasodilating effect

Answer 45

Nebivolol (TOPNOTCH)

Question 46

BB with local anesthetic effect

Answer 46

Propranolol (TOPNOTCH)

Question 47

BB which is safe in pregnant patients

Answer 47

Labetalol (TOPNOTCH)

Question 48

Mydriasis without cycloplegia

Answer 48

Phenylephrine (TOPNOTCH)

Question 49

Cholinesterase Inhbitors with poor lipid solubility, oral, DOA: 30min-2h

Answer 49

Neostigmine (TOPNOTCH)