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Topnotch PHARMA Aug2015 > I - Topnotch Pharma Flash Cards - Autonomics > Flashcards

I - Topnotch Pharma Flash Cards - Autonomics

1
Q

rapidly hydrolyzed by AChE

A

Acetylcholine (TOPNOTCH)

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2
Q

resistant to AChE

A

Betanechol (TOPNOTCH)

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3
Q

for Bladder and bowel atony

A

Betanechol (TOPNOTCH)

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4
Q

Nonselective muscarinic and nicotinic agonist , used topically for glaucoma treatment

A

Carbachol (TOPNOTCH)

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5
Q

Partial muscarinic agonist; used for treatment of Glaucoma, Sjogren’s syndrome and Sicca syndrome

A

Pilocarpine (TOPNOTCH)

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6
Q

Adverse Effects of Acetylcholine

A

CNS stimulation, miosis, cyclospasm, brochoconstriction, excessive GI and GU smooth muscle contraction, increased secretory activity of sweat gland, airways etc, vasodilation (TOPNOTCH)

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7
Q

activates autonomic post ganglionic neurons (both sympathetic and parasympathetic) and skeletal muscle neuromuscular end plates

A

Nicotine(TOPNOTCH)

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8
Q

used exclusively for smoking cessation

A

Varenicline (TOPNOTCH)

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9
Q

for Myasthenia gravis diagnosis (Tensilon test)

A

Edrophonium (TOPNOTCH)

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10
Q

for Myasthenia gravis treatment; reversal of nondepolarizing muscular blockade

A

Neostigmine (TOPNOTCH)

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11
Q

Long Acting Cholinesterase Inhibitors used as Scabicide and Insecticide

A

Malathion, Parathion (TOPNOTCH)

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12
Q

Competitively blocks all muscarinic receptors, antagonizes histamine and serotonin ; for motion sickness, dec. acid secretion in the GIT

A

Scopolamine (TOPNOTCH)

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13
Q

DOC for organophosphate poisoning

A

Atropine (TOPNOTCH)

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14
Q

for bradycardia, hypersalivation and to decrease airway secretion during general anesthesia

A

Atropine (TOPNOTCH)

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15
Q

Mydriatic, cycloplegic in eye examinations

A

Homatropine, Cyclopentolate, Tropicamide (TOPNOTCH)

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16
Q

Competitive nonselective antagonist at muscarinic receptors ; for BA and COPD, not as effective as SABAs but less tachycardia and arrhythmia

A

Ipratropium, Tiotropium (TOPNOTCH)

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17
Q

Nonselective muscarinic antagonist which reduces detrussor smooth muscle tone spasms

A

Oxybutinin (TOPNOTCH)

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18
Q

for decreasing urgency in mild cystitis and dec. bladder spasm after urologic surgery

A

Oxybutinin (TOPNOTCH)

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19
Q

Usual antidote for early stage (48h) cholinesterase inhibitor poisoning, Must be administered before 6-8 hours of organophosphate bond with cholinesterase occurs

A

Pralidoxime (TOPNOTCH)

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20
Q

Competitively blocks all Nn nicotinic Ach receptors ; for Hypertensive emergencies (obsolete)

A

Hexamethonium, Mecamylamine, Trimethaptan (TOPNOTCH)

21
Q

DOC for Anaphylaxis

A

Epinephrine (TOPNOTCH)

22
Q

used for Cardiac arrest, anaphylaxis, asthma, COPD, Hemostasis

A

Epinephrine (TOPNOTCH)

23
Q

for cardiogenic Shock and heart failure

A

Norepinephrine (TOPNOTCH)

24
Q

causes vasodilation in splanchnic and renal blood vessels ; for cardiogenic Shock and heart failure

A

Dopamine (TOPNOTCH)

25
Q

Beta nonselective sympathomimetic, for Asthma

A

Isoproterenol (TOPNOTCH)

26
Q

SE: Rebound nasal congestion, hypertension, stroke, MI

A

Phenylephrine (TOPNOTCH)

27
Q

A2 agonist, for Hypertension, Cancer pain, opioid withdrawal

A

Clonidine (TOPNOTCH)

28
Q

Sedation, rebound hypertension, dry mouth

A

Clonidine (TOPNOTCH)

29
Q

Sedation, positive Coomb’s test (Hemolytic anemia)

A

Methyldopa (TOPNOTCH)

30
Q

A2 agonist; reserved for ophthalmologic use in glaucoma for reduction of intraocular pressure

A

Apraclonidine, Brimonidine (TOPNOTCH)

31
Q

B1 agonist, for cardiogenic shock and acute heart failure

A

Dobutamine (TOPNOTCH)

32
Q

DOC as Asthma reliever, Rapid development of tolerance

A

Albuterol/Salbutamol (TOPNOTCH)

33
Q

D1 agonist, for Hypertension

A

Fenoldopam (TOPNOTCH)

34
Q

D2 agonist, restores dopamine actions in the CNS for Parkinson’s disease, prolactinemia

A

Bromocriptine (TOPNOTCH)

35
Q

Irreversibly blocks A1 and A2 receptors resulting to indirect baroreflex activation

A

Phenoxybenzamine (TOPNOTCH)

36
Q

Reversible A1 and A2 receptor antagonist, for Pheochromocytoma and Rebound hypertension

A

Phentolamine (TOPNOTCH)

37
Q

Blocks A1, for Benign Prostatic Hyperplasia, Hypertension

A

Prazosin, Doxazosin, Terazosin (TOPNOTCH)

38
Q

Slightly selective A1a blockade causing relaxation of prostatic smooth muscles > vascular smooth muscle ; for BPH

A

Tamsulosin (TOPNOTCH)

39
Q

Beta blockade > A1 blockade

A

Labetalol (TOPNOTCH)

40
Q

Blocks B1 and B2 receptors

A

Propranolol, Nadolol, Timolol (TOPNOTCH)

41
Q

B1 > B2 blockade

A

Metoprolol, Atenolol, Alprenolol, Betaxolol, Nebivolol (TOPNOTCH)

42
Q

B1, B2 with intrinsic sympathomimetic (partial agonist) effect

A

Pindolol, Acebutolol, Carteolol, Bopindolol, Oxprenolol, Celiprolol, Penbutolol (TOPNOTCH)

43
Q

Beta blockade > A1 blockade

A

Carvedilol, Medoxalol, Bucindolol, Labetalol (TOPNOTCH)

44
Q

B1 > B2 blockade; for rapid control of BP and arrhythmias, thyrotoxicosis and myocardial ischemia intraoperatively ; for Supraventricular tachycardia

A

Esmolol (TOPNOTCH)

45
Q

BB with direct vasodilating effect

A

Nebivolol (TOPNOTCH)

46
Q

BB with local anesthetic effect

A

Propranolol (TOPNOTCH)

47
Q

BB which is safe in pregnant patients

A

Labetalol (TOPNOTCH)

48
Q

Mydriasis without cycloplegia

A

Phenylephrine (TOPNOTCH)

49
Q

Cholinesterase Inhbitors with poor lipid solubility, oral, DOA: 30min-2h

A

Neostigmine (TOPNOTCH)

Topnotch PHARMA Aug2015 (8 decks)

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