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Question 1

Indications for Lotrimin

Answer 1

Superficial mycoses, such as tinea pedis, tinea curis, and ring worm, as well as yeast vaginitis

Question 2

MOA of Lotrimin

Answer 2

Binds to ergosterol molecules on fungus cell membrane and causes membrane leakage during cell division

Question 3

Lotrimin is used..

Answer 3

topically in locations and ointments

Question 4

Nystatin can be used..

Answer 4

both topically and systemically

Question 5

Indications for Nystatin

Answer 5

Superficial mycoses such as tinea pedis, curis, ring worm, thrush, oral candidiasis. Esophageal and vaginal Candida Cryptococcus also responsive.

Question 6

MOA of Nystatin

Answer 6

Binds to egosterol molecules

Question 7

What makes for diminished side effects of Nystatin?

Answer 7

Negligible oral absorption

Question 8

Used as prophylaxis in pts. at risk for fungal index. (ex. AIDS pts. and chemo pts.)

Answer 8

Nystatin

Question 9

Txt. of candidasis of oral cavity

Answer 9

Nystatin

Question 10

Most effective anti fungal for dermatophytes

Answer 10

Lamisil

Question 11

Side effects of Lamisil

Answer 11

Abdominal discomfort, diarrhea, nausea, headache. Less common: elevated liver enzymes, hepatitis, liver damage, and liver failure.

Question 12

Onychomoycosis txt.

Answer 12

Lamisil

Question 13

This fungal txt. inhibits fungal membrane synthesis

Answer 13

Diflucan

Question 14

Crytpococcus or Histoplasmosis are txt. by

Answer 14

Diflucan

Question 15

Side effects of Diflucan

Answer 15

N/V

Question 16

Txt. systemic fungal infections such

as systemic Candidadiasis, Histoplasmosis, Coccidiomycosis, Aspergillus and Blastomyces.

Answer 16

Amphocil

Question 17

Used for fungal meningitis or fungal brain abscesses

Answer 17

Amphocil

Question 18

Side effects of Amphocil

Answer 18

Very severe fevers and shaking chills “ampho-terrible”, hypotension, renal impairment, and severe anemia

Question 19

After two weeks of treatment, people with non-resistant active TB generally have markedly reduced infectivity or cease to be contagious. T/F?

Answer 19

T!

Question 20

Current txt of active TB:

Answer 20

Rifampin/ Rifadin
Isoniazid (INH) / Nitrazid
Pyrazinamide/ Pyrazinamide
Ethambutol/ Myambutol

Question 21

Rifampin is an…

Answer 21

antibiotic

Question 22

Indications for Rifampin

Answer 22

TB, MRSA, prophylactic txt. of N. meningitidis

Question 23

MOA of Rifampin

Answer 23

Inhibits DNA-dependent RNA polymerase

Question 24

Side effects of Rifampin

Answer 24

orange colored bodily fluids; fever, upset stomach, rash, nausea, hepatoxicity

Question 25

MOA of Isoniazid

Answer 25

Isoniazid is a pro-drug and must be activated by bacterial catalase. The activated form of INH inhibits the synthesis of mycolic acid in the mycobacterial cell wall.

Question 26

Lower doses of this drug should be given to people with liver disease

Answer 26

Isoniazid

Question 27

Side effects of Isoniazid

Answer 27

Rash, abnormal liver function tests, hepatitis, sideroblastic anemia, peripheral neuropathy and CNS effects. INH induced pyridoxine deficiency.

Question 28

Isoniazid

Answer 28

INH induced pyridoxine deficiency

Question 29

Avoid peripheral neuropathy with isoniazid by

Answer 29

Concurrent supplementation with pyridoxine