I - Cell Injury, Cell Death and Adaptations Flashcards
Increase in size of cells resulting in increased size of organ.
Hypertrophy
Increase in number of cells.
Hyperplasia
Hypertrophy of hyperplasia?Uterus during pregnancy
Both Estrogen stimulated SM hyperthrophy and hyperplasia
Hypertrophy or hyperplasia?Wound healing
Hyperplasia
Type of cell death characterized by nuclear dissolution, without complete loss of membrane integrity.
Apoptosis
Type of cell death which is energy-dependent, tightly regulated, and associated with normal cellular functions.
Apoptosis
Type of cell death which results from a pathologic cell injury.
Necrosis
Type of cell death associated with inflammation.
Necrosis
It is the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis.
Pyknosis
It is the destructive fragmentation of the nucleus of a dying cell.
Karyorrhexis
It is the complete dissolution of the chromatin of a dying cell.
Karyolysis
This is the first manifestation of almost all forms of injury to cells.
Cellular swelling
Small clear vacuoles within the cytoplasm, representing pinched-off segments of the endoplasmic reticulum.
Hydropic change or Vacuolar degeneration
Appearance of lipid vacuoles in the cytoplasm.
Fatty Change
Surface blebs, increased eosinophilia of the cytoplasm, cellular swelling.
Reversible/ Early Ischemic Injury
Cell injury with loss of nuclei, cellular fragmentation and leakage of cellular contents.
Irreversible/ Necrotic cellular injury(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.18
These are chemical species with a single unpaired electron in the outer orbital.
Free radicals(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.18
Most common cause of cell injury in clinical medicine.
Ischemia(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.18
Composed of membrane-bound vesicles of cytosol and organelles seen in programmed-cell death.
Apoptotic Bodies(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.19