hypovolaemic and distributive shock Flashcards

1
Q

what is shock? What is it due to in general terms?

A

Tissue Hypoxia (low oxygen), which can be due to:
* Reduced oxygen delivery to tissues
* Excessive oxygen demand/usage by tissues
* Inadequate utilisation of oxygen by tissues

Clinically, we usually care about the first of these (reduced delivery) and categorising which type is causing this.

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2
Q

what is metabolic shock?

A

hypoglycemic shock (not enough glucose therefore can’t combine with oxygen to make energy)

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3
Q

what is hypovolaemic shock

A

volume loss and therefore inability of body to get enough blood round the body

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4
Q

what are the causes of hypovolaemic shock?

A

Traumatic – blood extravasation or plasma and blood with severe bruising/third space loss.

Haemorrhage for other causes e.g. coagulopathy

Fluid loss e.g. severe vomiting and diarrhoea, or marked polyuria.

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5
Q

what is the clinical sign of hypovolaemic shock?

A

Clinical signs all relate to the body’s compensatory mechanisms to try and restore blood pressure:

Increase cardiac output – Tachycardia
Prioritise vital organs – peripheral vasoconstriction – pale mms, prolonged CRT, poor pulse quality.

When these mechs fail leads to shock - > reduced mentation due to reduced cerebral oxygen supply

needs to have reduced metatino inorder for it to be shock and not just hypovlaemic

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6
Q

what are the diagnostic markers for hypovolaemic shock?

A

Clinical signs and history plus:

Low blood pressure.

Elevated Lactate.

Point of care ultrasound:

Collapsing caudal vena cava (flat)
Poorly filling heart

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7
Q

what is the treatment for hypovolaemic shock?

A

Treatment depends on the cause but fundamentally is the same – restore the volume.

Fluid loss - > Isotonic Fluids

Blood/plasma loss - > Transfusion

In the real world we start with isotonic fluids in all circumstances, and then transfusion if necessary.

Speed is of the essence – hypoxia leads to brain death rapidly – so bolus fluids.

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8
Q

what is distributive shock?

A

(relavtive hypovolaemia) -
is a state of relative hypovolemia resulting from pathological redistribution of the absolute intravascular volume.

dilation of vessles

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9
Q

what are the causes of distributive shock?

A

Primarily as result of inappropriate vasodilation, however ‘leaky vessels’ also plays a role.

Sepsis/SIRS is probably the most common version you will see, the inflammatory cascade releasing pro-inflammatory cytokines that promote vasodilation and permeability.

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10
Q

what are the clinical signs of distributive shock?

A

Vasodilation - > injected mucous membranes, shortened CRT (pooling of blood in membrane capillaries), bounding/hyperdynamic pulse. Tachycardia due to hypotension.

Permeability - > peripheral oedema (sepsis causes leaky vessles), pulmonary oedema, cavitatory effusions.

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11
Q

what is the diagnosis of distributive shock?

A

Clinical signs and history plus:

Low blood pressure.

Elevated Lactate.

Point of care ultrasound:
* Collapsing caudal vena cava (flat)
* Poorly filling heart
* Septic focus e.g. septic abdomen (free fluid)
* Evidence of vascular leak e.g. pulmonary oedema, small effusions.
* Gall bladder halo sign (oedema of the wall)

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12
Q

what is the most common cause of systemic odema?

A

spesis - it causes leaking vessels and because it is a systemic disease it affects everywhere and therefore there is odema everywhere

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13
Q

what is systolic pressure?

A

measure of ventricular (pump) function

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14
Q

what is diastolic pressure?

A

the tone in the vessles (pipes)

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15
Q

why does boundign/hyperdymanic pluse occur with vasodilation? how do you test for a boundign pulse?

A

vassular tone is lost and therefore the heart has to work harder to maintian the the circulation - large systolic pressure and small diastolic (can be affected with adrenaline)
low MAP or press harder and will occlude the vein (bounding can be occulded)
pumps obviously but weakly as often hypovolaemic aswell

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16
Q

how do you treat distributive shock?

A

Treatment is focused on vascular tone and permeability, but also needs some volume support (there are more ‘pipes’ to fill now)

Volume support – fluid bolus

Vascular tone support – vasopressors such as noradrenaline or dopamine.

Permeability support – ensuring oncotic pressure is adequate:
* Check albumin levels
* If low, consider plasma transfusion
* Start feeding e.g. a feeding tube

17
Q

what are the two vasopressors used in shock?

A

noradrenaline,
dopamine - Probably less effective in cats

18
Q

what receptors does noradreanline work on? what does it cause?

A

periopheral vasoconstriction via aphla one receptors

19
Q

what is the effect of dopamine? what affectors does it act on?

A

Direct dopaminergic effects on alpha and beta receptors

Overall, it redirects blood flow to the major organs at low doses, at mid-range to higher doses it increases systemic vascular resistance (alpha-1) and increases heart rate (beta-1)

20
Q

what does sepsis sometimes occur with acute haemorrhagic diarrhoea syndrome.

A

the intestines are damaged and therefore the bacteria can get to the blood stream and causes sepsis

21
Q

what will an animal with both hypovolaemic and distributive shock present as?

A

tachycardia, bounding pluse, poor mentation,
normal CRT, mm, temperature

22
Q

how can you work out of you have both hypovolaemic and distributive shock?

A

POCUS
flat vena cava and poor filling of heart

23
Q

how would you treat a possible hypovolaemic and distributive shock?

A

treatment trial - treat for hypovolaemia, 3 boluses and then vasoconstictors

24
Q

what are the 4 types of shock?

A

volume:
- hypovolaemic (reduced volume)
- distributive (increased diametre or pipes)

output
- cardiogenic (failure of pump - electrical)
- obstructive (fluid around heart, thrombus)