Hypothalamus Flashcards
1
Q
list the cAMP signaling pathway hormones
A
FLAT ChAMP
- FSH
- LH
- ACTH
- TSH
- CRH
- hCG
- ADH (V2, collecting ducts)
- MSH
- PTH
2
Q
list the IP3 signaling pathway hormones
A
GOAT HAG
- GnRH
- Oxytocin
- ADH (V1, blood vessels)
- TRH
- Histamine
- AGII
- Gastrin
3
Q
list the intracellular signaling pathway hormones
A
PET CAT on TV
- Progesterone
- Estrogen
- Testosterone
- Cortisol
- Aldosterone
- T3/T4
- Vitamin D
4
Q
describe panhypopituitarism
A
- deficinecy of all pituitary hormones
- Sheehan’s syndrome can occur due to postpartum hemorrhage
5
Q
describe the functions of prolactin
A
- breast development and milk production but NOT EJECTION of milk (oxytocin)
- inhibits ovulation in lactating female suppressing GnRH synthesis and release
- increase in TRH stimulates prolactin release
- estradiol inhibits dopamine, which stimulates prolactin release
6
Q
what is the signalling pathway of prolactin?
A
tyrosine kinase
7
Q
describe disorders of prolactin imbalance
A
- excess secretion of hormone causes:
- galactorrhea
- decreased libido
- decreased ovulation and spermatogenesis by inhibiting GnRH
- dopamine agonist, bromocriptine can be used to treat excess prolatcin secretion
8
Q
what increases secretion of ADH from PP?
A
- increased ECF osmolarity (osmoreceptors)
- decreased ECF volume (baroreceptors)
9
Q
describe the MoA of ADH in the kidney (collecting duct)
A
principal cells
- V2R receptors in CD via cAMP
10
Q
describe the MoA of ADH on the blood vessels
A
- V1R receptors via IP3/DAG
- contraction of blood vessles
11
Q
describe SIADH
A
- SIADH is an increase in ADH secretion by a tumor (such as oat cell carcinoma of the lung)
- results in:
- ADH secretion -> H2O retention
- increase in urinary concentration
- decrease in serum osmolarity
12
Q
describe treatment for SIADH
A
treatment = ADH antagonist (democycline) or water restriction
13
Q
A
